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Neck Pain

Neuroscience · NLM MeSH · updated 2026-10-29 · version 1

Citations verified against PubMedNot yet clinician-reviewed10 referencesApproximately 5 min read

Discomfort or more intense forms of pain that are localized to the cervical region.

Table of Contents

1. Definition2. Research landscape3. Reading the evidence4. Open-access studies5. Key reviews6. References7. About this article

Definition and research guide

This page combines a MeSH definition, publication statistics and selected research abstracts. It is a starting point for reading the literature, not a medical textbook or a systematic evidence review.

Content available: 4 complete abstracts (1,083 words), 10 references. Full article text is not stored or reproduced here; follow the PMID, DOI or PMC links to read the original sources and their access terms.

Definition

Discomfort or more intense forms of pain that are localized to the cervical region. This term generally refers to pain in the posterior or lateral regions of the neck.

Definition: NLM Medical Subject Headings (MeSH) scope note (Public domain (U.S. National Library of Medicine); attribution requested). View the MeSH record.

Also known as: Neck Pains; Pain, Neck; Pains, Neck; Cervical Pain; Cervical Pains; Pain, Cervical; Pains, Cervical; Cervicalgia.

Where it fits in the MeSH classification

Broader topics
Pain
Narrower topics
Cervical Dizziness

Research landscape

PubMed indexes 10,028 records tagged with the MeSH heading “Neck Pain” (counts retrieved 2026-10-29). 3,002 of them (29.9%) were published from 2020 onward, and the busiest period so far is 2010-2019 with 4,234 records.

Reviews account for 1,308 records (13.0%) and meta-analyses for 321. Randomized controlled trials number 1,310 (13.1%) as a share of all records on the topic. Randomized trials make up a comparatively large share of this literature, which means many treatment questions have been tested directly.

PubMed records by publication periodthrough 1999: 267 records; 2000-2009: 2,525 records; 2010-2019: 4,234 records; 2020 onward: 3,002 records267through 19992,5252000-20094,2342010-20193,0022020 onward
Records in PubMed indexed with this heading, by publication period. Real counts from NCBI E-utilities; the final period covers only part of the current year. Volume reflects how much has been published, not how strong the evidence is.
Show the data
PeriodRecords
through 1999267
2000-20092,525
2010-20194,234
2020 onward3,002
Share of records by publication typeReviews: 13.0 percent; Meta-analyses: 3.2 percent; Randomized controlled trials: 13.1 percentReviews13.0% (1,308)Meta-analyses3.2% (321)Randomized controlled trials13.1% (1,310)
Share of all PubMed records on this heading that carry each publication type. Types overlap with other records, so the shares do not sum to 100%.
Publication-type chart data
Publication types among 10,028 PubMed records
TypeRecordsShare
Reviews1,30813.0%
Meta-analyses3213.2%
Randomized controlled trials1,31013.1%

Method: PubMed query "Neck Pain"[MeSH Terms] with publication-type and date filters, retrieved 2026-10-29.

Reading the evidence in neuroscience

Neuroscience draws on tools with different strengths: cellular and animal work can manipulate circuits directly, while human imaging and electrophysiology observe the living brain at lower resolution. Small imaging studies are prone to false positives, and findings in animals do not always carry over to people. Clinical neurology and psychiatry rely on trials and cohort studies whose outcomes are often symptom scales. Check the species, the sample size, how the outcome was measured and whether results were replicated.

Evidence from open-access studies

These open-access studies come from PubMed’s best-match results for this heading (papers whose main topic it is), ranked here by citation count, with one recent addition. Each abstract is reproduced in full under its recorded open licence so that you can read the authors’ own words. They illustrate the literature; they are not a systematic summary of it. Citation counts measure attention, not reliability or clinical benefit.

Study comparison — selected abstracts, not a systematic review
Study / authorsYearSource label / designEurope PMC citationsLicence / source
The effects of exercise on neuromuscular function in people with chronic neck pain: A systematic review and meta-analysis
Dirito AM, Abichandani D, Jadhakhan F, Falla D
2024Meta-analysis
Design not recorded in structured metadata
15cc by
PMID 39700104 · DOI · PMC11658605
Illness perceptions in people with chronic and disabling non-specific neck pain seeking primary healthcare: a qualitative study
Kragting M, Pool-Goudzwaard AL, Coppieters MW, O'Sullivan PB, Voogt L
2024Research article
Design not recorded in structured metadata
12cc by
PMID 38413876 · DOI · PMC10900625
Acupuncture for Japanese Katakori (Chronic Neck Pain): A Randomized Placebo-Controlled Double-Blind Study
Takakura N, Takayama M, Kawase A, Kaptchuk TJ, Kong J, Vangel M, et al.
2023Randomized controlled trial
Design not recorded in structured metadata
10cc by
PMID 38138244 · DOI · PMC10745119
Navigating Health Care with Concurrent Jaw and Neck Pain: A Patient-Centered Perspective
Böthun A, Fjellman-Wiklund A, Durham J, Hellström F, Häggman-Henrikson B, Lövgren A
2026Research article
Design not recorded in structured metadata
2cc by
PMID 40948105 · DOI · PMC13232580

The effects of exercise on neuromuscular function in people with chronic neck pain: A systematic review and meta-analysis [1]

Meta-analysis Dirito AM, Abichandani D, Jadhakhan F, Falla D · · 2024 · cited 15 times (Europe PMC)

Abstract reading summary — source excerpts
Opening excerpt
BackgroundDifferences in cervical neuromuscular function are commonly observed between people with and without chronic neck pain.
Closing excerpt
Specificity of training was seen to be relevant for the type of neuromuscular adaptations induced.
Interpretation limits
Verbatim excerpts from the authors’ abstract; the closing excerpt may describe a finding, limitation or recommendation. Design, population, effect size and uncertainty have not been independently extracted or appraised. Read the complete abstract and linked paper before interpreting the findings.
Read complete abstract (235 words)

BackgroundDifferences in cervical neuromuscular function are commonly observed between people with and without chronic neck pain. Exercise may improve cervical neuromuscular function of people with neck pain although the evidence for this has not been systematically reviewed.ObjectiveTo systematically review the existing evidence on the effect of exercises targeting the neck muscles on neuromuscular function in people with chronic non-specific neck pain.MethodsThis systematic review was conducted based on a registered protocol (CRD42021298831) with searches conducted on the following databases from inception to 21st October 2023: MEDLINE, CINAHL, Web of Science, Scopus, AMED, Google Scholar, Open Grey and Zetoc. Studies of interest were trials investigating neuromuscular adaptations to a program of exercise targeting the neck muscles (>2 weeks) in people with chronic non-specific neck pain. Two reviewers independently screened the studies and performed data extraction, risk of bias assessment, and rated the overall certainty of the evidence (GRADE).ResultsFourteen articles from 2110 citations were included. There is moderate certainty of evidence that the use of craniocervical flexion training (either in isolation or in combination with resistance training) can induce neural adaptations within the neck muscles. A meta-analysis showed a reduction in sternocleidomastoid muscle activity after neck exercise interventions compared to control interventions.ConclusionThe articles included in this systematic review confirmed that exercise can result in neuromuscular adaptations within neck muscles, as measured by electromyography. Specificity of training was seen to be relevant for the type of neuromuscular adaptations induced.

Abstract reproduced from the open-access article under the recorded cc by licence; © the authors. PMID 39700104 · DOI · PMC11658605

Illness perceptions in people with chronic and disabling non-specific neck pain seeking primary healthcare: a qualitative study [2]

Research article Kragting M, Pool-Goudzwaard AL, Coppieters MW, O'Sullivan PB, Voogt L · · 2024 · cited 12 times (Europe PMC)

Abstract reading summary — source excerpts
Opening excerpt
BackgroundIllness perceptions can affect the way people with musculoskeletal pain emotionally and behaviorally cope with their health condition.
Closing excerpt
Addressing this 'sense making process' is a prerequisite for providing patient-centered care.
Interpretation limits
Verbatim excerpts from the authors’ abstract; the closing excerpt may describe a finding, limitation or recommendation. Design, population, effect size and uncertainty have not been independently extracted or appraised. Read the complete abstract and linked paper before interpreting the findings.
Read complete abstract (239 words)

BackgroundIllness perceptions can affect the way people with musculoskeletal pain emotionally and behaviorally cope with their health condition. Understanding patients illness perceptions may help facilitate patient-centered care. The purpose of this study was to explore illness perceptions and the origin of those perceptions in people with chronic disabling non-specific neck pain seeking primary care.MethodsA qualitative study using a deductive and inductive analytical approach was conducted in 20 people with persistent (> 3 months) and disabling (i.e., Neck Disability Index ≥ 15) neck pain. Using a semi-structured format, participants were interviewed about their illness perceptions according to Leventhal's Common Sense Model. Purposive sampling and member checking were used to secure validity of study results.ResultsParticipants reported multiple symptoms, thoughts and emotions related to their neck pain, which continuously required attention and action. They felt trapped within a complex multifactorial problem. Although some participants had a broader biopsychosocial perspective to understand their symptoms, a biomedical perspective was dominant in the labelling of their condition and their way of coping (e.g., limiting load, building strength and resilience, regaining mobility, keep moving and being meaningful). Their perceptions were strongly influenced by information from clinicians. Several participants indicated that they felt uncertain, because the information they received was contradictory or did not match their own experiences.ConclusionMost participants reported that understanding their pain was important to them and influenced how they coped with pain. Addressing this 'sense making process' is a prerequisite for providing patient-centered care.

Abstract reproduced from the open-access article under the recorded cc by licence; © the authors. PMID 38413876 · DOI · PMC10900625

Acupuncture for Japanese Katakori (Chronic Neck Pain): A Randomized Placebo-Controlled Double-Blind Study [3]

Randomized controlled trial Takakura N, Takayama M, Kawase A, Kaptchuk TJ, Kong J, Vangel M, et al. · · 2023 · cited 10 times (Europe PMC)

Abstract reading summary — source excerpts
Opening excerpt
Background and Objectives: Although acupuncture is listed as a beneficial treatment for neck/shoulder stiffness, which has increased with the spread of information technology, to date, evidence of its efficacy under double-blind conditions has not been shown.
Closing excerpt
Our study provides important evidence of acupuncture efficacy and information regarding inert no-touch placebo control in acupuncture research.
Interpretation limits
Verbatim excerpts from the authors’ abstract; the closing excerpt may describe a finding, limitation or recommendation. Design, population, effect size and uncertainty have not been independently extracted or appraised. Read the complete abstract and linked paper before interpreting the findings.
Read complete abstract (260 words)

Background and Objectives: Although acupuncture is listed as a beneficial treatment for neck/shoulder stiffness, which has increased with the spread of information technology, to date, evidence of its efficacy under double-blind conditions has not been shown. This study aimed to assess whether acupuncture treatment with superficial skin piercing is superior to placebo treatment. Materials and Methods: A randomized, double-blind (practitioner-patient) placebo-controlled trial was performed at a single center with four arms (ISRCTN76896018). Four hundred patients with essential neck/shoulder stiffness were randomly assigned to penetrating needle treatment (acupuncture ritual and skin penetration), skin-touch needle treatment (acupuncture ritual and skin touch), no-touch needle treatment (acupuncture ritual alone), and no-treatment control. Each of the six acupuncturists applied a needle to each of the four acupoints in the neck/shoulder of 50 patients. Results: Each of the three treatments significantly (p = 0.01) improved neck/shoulder stiffness compared with the no-treatment control immediately and 24 h after treatment. There was a significant improvement in penetrating needle treatment over no-touch needle treatment 24 h later. However, there was no significant difference between the penetrating and skin-touch and skin-touch vs. no-touch. Conclusions: All treatments that received the ritual of acupuncture were better than the no-treatment control. Only genuine acupuncture involves the specific effects of needle insertion into the body. The acupuncture ritual had a significant impact on the subjective improvement of neck/shoulder stiffness; however, improvement with ritual alone versions of placebo acupuncture was not maintained as with superficial skin piercing. Our study provides important evidence of acupuncture efficacy and information regarding inert no-touch placebo control in acupuncture research.

Abstract reproduced from the open-access article under the recorded cc by licence; © the authors. PMID 38138244 · DOI · PMC10745119

Navigating Health Care with Concurrent Jaw and Neck Pain: A Patient-Centered Perspective [4]

Research article Böthun A, Fjellman-Wiklund A, Durham J, Hellström F, Häggman-Henrikson B, Lövgren A · · 2026 · cited 2 times (Europe PMC)

Abstract reading summary — source excerpts
Opening excerpt
IntroductionConcurrent pain in the jaw and neck is common; however, little is known about how it develops.
Closing excerpt
A holistic approach and increased collaboration between dentistry and health care are needed to support patients navigating health care providers and reduce the risk of pain chronification.
Interpretation limits
Verbatim excerpts from the authors’ abstract; the closing excerpt may describe a finding, limitation or recommendation. Design, population, effect size and uncertainty have not been independently extracted or appraised. Read the complete abstract and linked paper before interpreting the findings.
Read complete abstract (349 words)

IntroductionConcurrent pain in the jaw and neck is common; however, little is known about how it develops. Previous studies have focused mainly on biological factors with limited focus on psychosocial factors and patients' perspectives. To enhance understanding of concurrent jaw and neck pain, knowledge is needed about patients' perspectives on the development of symptoms and their management within health care that also includes dentistry.ObjectiveTo explore patients' perspectives on the development of concurrent jaw and neck pain in relation to navigating the health care system.MethodsSixteen individuals (11 women and 5 men, aged 19 to 56 y) with concurrent jaw and neck pain were recruited using purposive sampling. Participants were patients referred to an orofacial pain specialist in Sweden. Individual semi-structured interviews were used and analyzed using qualitative content analysis.ResultsData analysis resulted in the theme "Seeking understanding, confirmation, and simplified navigation in the health care system." The main theme consisted of 3 subthemes: (1) understanding and interpreting the body and emotions holistically, (2) seeking affirmation and legitimacy from health care, and (3) wishing for clear and easily navigable health care pathways. Patients expressed thoughts regarding their own sensemaking in respect to causes for their pain. Moreover, they requested confirmation from health care along with simplified health care navigation and a holistic approach regarding pain management.ConclusionsA mismatch exists between the patient's own sensemaking regarding the cause of their jaw and neck pain and the care they receive from their health care provider. Having pain from multiple sites that is managed in different medical systems makes it difficult to navigate within health care. A clear care pathway could reduce the risk of pain chronicity, and an increased collaboration between dentistry and medical care would be desirable.Knowledge Transfer Statement:Concurrent jaw and neck pain is common but often managed separately in dentistry and health care. This can result in a mismatch between a patient's understanding regarding concurrent jaw and neck pain and directions from their health care provider. A holistic approach and increased collaboration between dentistry and health care are needed to support patients navigating health care providers and reduce the risk of pain chronification.

Abstract reproduced from the open-access article under the recorded cc by licence; © the authors. PMID 40948105 · DOI · PMC13232580

Key reviews and meta-analyses

The most cited review-type papers among PubMed’s best-match results for this heading, listed with bibliographic details only. Follow the links for the full text and access terms.

  • Research article Neck Pain: Revision 2017 [5]
    Blanpied PR, Gross AR, Elliott JM, Devaney LL, Clewley D, Walton DM, et al. · J Orthop Sports Phys Ther · 2017 · cited 599 times (Europe PMC)
  • Research article Epidemiology, diagnosis, and treatment of neck pain [6]
    Cohen SP · Mayo Clin Proc · 2015 · cited 389 times (Europe PMC)
  • Research article Neck pain: global epidemiology, trends and risk factors [7]
    Kazeminasab S, Nejadghaderi SA, Amiri P, Pourfathi H, Araj-Khodaei M, Sullman MJM, et al. · BMC Musculoskelet Disord · 2022 · cited 373 times (Europe PMC)
  • Research article Efficacy of low-level laser therapy in the management of neck pain: a systematic review and meta-analysis of randomised placebo or active-treatment controlled trials [8]
    Chow RT, Johnson MI, Lopes-Martins RA, Lopes-Martins RA, Bjordal JM · Lancet · 2009 · cited 357 times (Europe PMC)
  • Research article Advances in the diagnosis and management of neck pain [9]
    Cohen SP, Hooten WM · BMJ · 2017 · cited 241 times (Europe PMC)
  • Research article Management of neck pain and associated disorders: A clinical practice guideline from the Ontario Protocol for Traffic Injury Management (OPTIMa) Collaboration [10]
    Côté P, Wong JJ, Sutton D, Shearer HM, Mior S, Randhawa K, et al. · Eur Spine J · 2016 · cited 205 times (Europe PMC)

References

  1. Dirito AM, Abichandani D, Jadhakhan F, Falla D. The effects of exercise on neuromuscular function in people with chronic neck pain: A systematic review and meta-analysis. . 2024. PMID 39700104 · DOI · PMC11658605
  2. Kragting M, Pool-Goudzwaard AL, Coppieters MW, O'Sullivan PB, Voogt L. Illness perceptions in people with chronic and disabling non-specific neck pain seeking primary healthcare: a qualitative study. . 2024. PMID 38413876 · DOI · PMC10900625
  3. Takakura N, Takayama M, Kawase A, Kaptchuk TJ, Kong J, Vangel M, et al.. Acupuncture for Japanese Katakori (Chronic Neck Pain): A Randomized Placebo-Controlled Double-Blind Study. . 2023. PMID 38138244 · DOI · PMC10745119
  4. Böthun A, Fjellman-Wiklund A, Durham J, Hellström F, Häggman-Henrikson B, Lövgren A. Navigating Health Care with Concurrent Jaw and Neck Pain: A Patient-Centered Perspective. . 2026. PMID 40948105 · DOI · PMC13232580
  5. Blanpied PR, Gross AR, Elliott JM, Devaney LL, Clewley D, Walton DM, et al.. Neck Pain: Revision 2017. J Orthop Sports Phys Ther. 2017. PMID 28666405 · DOI
  6. Cohen SP. Epidemiology, diagnosis, and treatment of neck pain. Mayo Clin Proc. 2015. PMID 25659245 · DOI
  7. Kazeminasab S, Nejadghaderi SA, Amiri P, Pourfathi H, Araj-Khodaei M, Sullman MJM, et al.. Neck pain: global epidemiology, trends and risk factors. BMC Musculoskelet Disord. 2022. PMID 34980079 · DOI · PMC8725362
  8. Chow RT, Johnson MI, Lopes-Martins RA, Lopes-Martins RA, Bjordal JM. Efficacy of low-level laser therapy in the management of neck pain: a systematic review and meta-analysis of randomised placebo or active-treatment controlled trials. Lancet. 2009. PMID 19913903 · DOI
  9. Cohen SP, Hooten WM. Advances in the diagnosis and management of neck pain. BMJ. 2017. PMID 28807894 · DOI
  10. Côté P, Wong JJ, Sutton D, Shearer HM, Mior S, Randhawa K, et al.. Management of neck pain and associated disorders: A clinical practice guideline from the Ontario Protocol for Traffic Injury Management (OPTIMa) Collaboration. Eur Spine J. 2016. PMID 26984876 · DOI

About this article

Sources
NLM Medical Subject Headings (definition, synonyms); NCBI PubMed (counts, identifiers); Europe PMC (open-access abstracts and citation counts).
Verification
Every reference was resolved against PubMed on 2026-10-31; title, year and DOI matched.
Review state
automated source verified; no human expert review has been recorded yet.
Version
1, last updated 2026-10-29.

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At a glance

10,028
PubMed records on this heading
30%
published since 2020
1,308
review articles
1,310
randomized trials
10
verified references below

Counts come from PubMed on 2026-10-29; they show how much has been written, not how strong the evidence is.

Related topics See all →

  • Acute PainNeuroscience
  • Shoulder PainNeuroscience
  • Back PainNeuroscience
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