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Palm Oil

Drugs and Chemicals · NLM MeSH · updated 2026-10-31 · version 1

Citations verified against PubMedNot yet clinician-reviewed10 referencesApproximately 6 min read

Nutritive oil extracted from the fleshy mesocarp of the fruit of the African palm tree, Elaeis guineensis.

Table of Contents

1. Definition2. Research landscape3. Reading the evidence4. Open-access studies5. Key reviews6. References7. About this article

Definition and research guide

This page combines a MeSH definition, publication statistics and selected research abstracts. It is a starting point for reading the literature, not a medical textbook or a systematic evidence review.

Content available: 4 complete abstracts (1,134 words), 10 references. Full article text is not stored or reproduced here; follow the PMID, DOI or PMC links to read the original sources and their access terms.

Definition

Nutritive oil extracted from the fleshy mesocarp of the fruit of the African palm tree, Elaeis guineensis.

Definition: NLM Medical Subject Headings (MeSH) scope note (Public domain (U.S. National Library of Medicine); attribution requested). View the MeSH record.

Also known as: Oil, Palm; Palmolein.

Where it fits in the MeSH classification

Broader topics
Dietary Fats; Plant Oils

Research landscape

PubMed indexes 2,389 records tagged with the MeSH heading “Palm Oil” (counts retrieved 2026-10-31). 756 of them (31.6%) were published from 2020 onward, and the busiest period so far is 2010-2019 with 1,102 records.

Reviews account for 135 records (5.7%) and meta-analyses for 8. Randomized controlled trials number 111 (4.6%) as a share of all records on the topic.

PubMed records by publication periodthrough 1999: 147 records; 2000-2009: 384 records; 2010-2019: 1,102 records; 2020 onward: 756 records147through 19993842000-20091,1022010-20197562020 onward
Records in PubMed indexed with this heading, by publication period. Real counts from NCBI E-utilities; the final period covers only part of the current year. Volume reflects how much has been published, not how strong the evidence is.
Show the data
PeriodRecords
through 1999147
2000-2009384
2010-20191,102
2020 onward756
Share of records by publication typeReviews: 5.7 percent; Meta-analyses: 0.3 percent; Randomized controlled trials: 4.6 percentReviews5.7% (135)Meta-analyses0.3% (8)Randomized controlled trials4.6% (111)
Share of all PubMed records on this heading that carry each publication type. Types overlap with other records, so the shares do not sum to 100%.
Publication-type chart data
Publication types among 2,389 PubMed records
TypeRecordsShare
Reviews1355.7%
Meta-analyses80.3%
Randomized controlled trials1114.6%

Method: PubMed query "Palm Oil"[MeSH Terms] with publication-type and date filters, retrieved 2026-10-31.

Reading the evidence in drugs and chemicals

Studies of a chemical or drug can answer very different questions: what it is and how it behaves in cells and animals, how the body handles it, and whether it changes outcomes in people. Laboratory and animal findings often do not carry over to patients, and observational studies of exposures are confounded by who uses a substance and why. Nothing on this page is a recommendation to use, avoid, start or stop any substance or medicine; talk to a qualified clinician or pharmacist about your own situation. Check the dose, the species, the comparison group and whether a patient-relevant outcome was measured.

Evidence from open-access studies

These open-access studies come from PubMed’s best-match results for this heading (papers whose main topic it is), ranked here by citation count, with one recent addition. Each abstract is reproduced in full under its recorded open licence so that you can read the authors’ own words. They illustrate the literature; they are not a systematic summary of it. Citation counts measure attention, not reliability or clinical benefit.

Study comparison — selected abstracts, not a systematic review
Study / authorsYearSource label / designEurope PMC citationsLicence / source
Systematic review of palm oil consumption and the risk of cardiovascular disease
Ismail SR, Maarof SK, Siedar Ali S, Ali A
2018Systematic review
Design not recorded in structured metadata
52cc by
PMID 29489910 · DOI · PMC5831100
Optimization of process parameters in preparation of tocotrienol-rich red palm oil-based nanoemulsion stabilized by Tween80-Span 80 using response surface methodology
Chong WT, Tan CP, Cheah YK, B Lajis AF, Habi Mat Dian NL, Kanagaratnam S, et al.
2018Research article
Design not recorded in structured metadata
49cc by
PMID 30142164 · DOI · PMC6108518
Palm Oil on the Edge
Gesteiro E, Guijarro L, Sánchez-Muniz FJ, Vidal-Carou MDC, Troncoso A, Venanci L, et al.
2019Review article
Design not recorded in structured metadata
43cc by
PMID 31454938 · DOI · PMC6770503
Occupancy estimation of wild species in a palm oil plantation using unstructured data
van Strien AJ, Meijaard E, Nardiyono, Suief S, Zaini S
2026Research article
Design not recorded in structured metadata
1cc by
PMID 41628261 · DOI · PMC12863681

Systematic review of palm oil consumption and the risk of cardiovascular disease [1]

Systematic review Ismail SR, Maarof SK, Siedar Ali S, Ali A · · 2018 · cited 52 times (Europe PMC)

Abstract reading summary — source excerpts
Opening excerpt
BackgroundThe high amount of saturated fatty acids (SFA) coupled with the rising availability and consumption of palm oil have lead to the assumption that palm oil contributes to the increased prevalence of cardiovascular diseases worldwide.
Closing excerpt
A healthy overall diet should still be prioritised for good cardiometabolic health.
Interpretation limits
Verbatim excerpts from the authors’ abstract; the closing excerpt may describe a finding, limitation or recommendation. Design, population, effect size and uncertainty have not been independently extracted or appraised. Read the complete abstract and linked paper before interpreting the findings.
Read complete abstract (487 words)

BackgroundThe high amount of saturated fatty acids (SFA) coupled with the rising availability and consumption of palm oil have lead to the assumption that palm oil contributes to the increased prevalence of cardiovascular diseases worldwide. We aimed at systematically synthesising the association of palm oil consumption with cardiovascular disease risk and cardiovascular disease-specific mortality.MethodsWe systematically searched Central, Medline and Embase databases up to June 2017 without restriction on setting or language. We performed separate searches based on the outcomes: coronary heart disease and stroke, using keywords related to these outcomes and palm oil. We searched for published interventional and observational studies in adults (Age: >18 years old). Two investigators extracted data and a consensus was reached with involvement of a third. Only narrative synthesis was performed for all of the studies, as the data could not be pooled.ResultsOur search retrieved 2,738 citations for stroke with one included study and 1,777 citations for coronary heart disease (CHD) with four included studies. Palmitic acid was reported to be associated with risk of myocardial infarction (MI) (OR 2.76; 95%CI = 1.39-5.47). Total SFA intake was reported to be not significant for risk of MI. Varying intake of fried foods, highest contributor to total SFA with 36% of households using palm oil for frying, showed no significant associations to risk of MI. Odds of developing first non-fatal acute MI was higher in palm oil compared to soybean oil with 5% trans-fat (OR = 1.33; 95%CI = 1.09-1.62) than palm oil compared to soybean oil with 22% trans-fat (OR = 1.16; 95%CI = 0.86-1.56). Nevertheless, these risk estimates were non-significant and imprecise. The trend amongst those taking staple pattern diet (characterised by higher palm oil, red meat and added sugar consumption) was inconsistent across the factor score quintiles. During the years of 1980 and 1997, for every additional kilogram of palm oil consumed per-capita annually, CHD mortality risk was 68 deaths per 100,000 (95% CI = 21-115) in developing countries and 17 deaths per 100,000 (95%CI = 5.3-29) in high-income countries, whereas stroke was associated with 19 deaths per 100,000 (95%CI = -12-49) and 5.1 deaths per 100,000 (95% CI: -1.2-11) respectively. The evidence for the outcomes of this review were all graded as very low. The findings of this review should be interpreted with some caution, owing to the lack of a pooled effect estimate of the association, significant bias in selection criteria and confounding factors, inclusion of other food items together with palm oil, and the possible out-dated trend in the ecological study.ConclusionIn view of the abundance of palm oil in the market, quantifying its true association with CVD outcomes is challenging. The present review could not establish strong evidence for or against palm oil consumption relating to cardiovascular disease risk and cardiovascular disease-specific mortality. Further studies are needed to establish the association of palm oil with CVD. A healthy overall diet should still be prioritised for good cardiometabolic health.

Abstract reproduced from the open-access article under the recorded cc by licence; © the authors. PMID 29489910 · DOI · PMC5831100

Optimization of process parameters in preparation of tocotrienol-rich red palm oil-based nanoemulsion stabilized by Tween80-Span 80 using response surface methodology [2]

Research article Chong WT, Tan CP, Cheah YK, B Lajis AF, Habi Mat Dian NL, Kanagaratnam S, et al. · · 2018 · cited 49 times (Europe PMC)

Abstract reading summary — source excerpts
Opening excerpt
Red palm oil (RPO) is a natural source of Vitamin E (70-80% tocotrienol).
Closing excerpt
The actual values of the formulated nanoemulsion were in good agreement with the predicted values obtained from RSM, thus the optimized compositions have the potential to be used as a nanoemulsion for cosmetic formulations.
Interpretation limits
Verbatim excerpts from the authors’ abstract; the closing excerpt may describe a finding, limitation or recommendation. Design, population, effect size and uncertainty have not been independently extracted or appraised. Read the complete abstract and linked paper before interpreting the findings.
Read complete abstract (197 words)

Red palm oil (RPO) is a natural source of Vitamin E (70-80% tocotrienol). It is a potent natural antioxidant that can be used in skin-care products. Its antioxidant property protects skin from inflammation and aging. In our work, a tocotrienol-rich RPO-based nanoemulsion formulation was optimized using response surface methodology (RSM) and formulated using high pressure homogenizer. Effect of the concentration of three independent variables [surfactant (5-15 wt%), co-solvent (10-30 wt%) and homogenization pressure (500-700 bar)] toward two response variables (droplet size, polydispersity index) was studied using central composite design (CCD) coupled to RSM. RSM analysis showed that the experimental data could be fitted into a second-order polynomial model and the coefficients of multiple determination (R2) is 0.9115. The optimized formulation of RPO-based nanoemulsion consisted of 6.09 wt% mixed surfactant [Tween 80/Span 80 (63:37, wt)], 20 wt% glycerol as a co-solvent via homogenization pressure (500 bar). The optimized tocotrienol-rich RPO-based nanoemulsion response values for droplet size and polydispersity index were 119.49nm and 0.286, respectively. The actual values of the formulated nanoemulsion were in good agreement with the predicted values obtained from RSM, thus the optimized compositions have the potential to be used as a nanoemulsion for cosmetic formulations.

Abstract reproduced from the open-access article under the recorded cc by licence; © the authors. PMID 30142164 · DOI · PMC6108518

Palm Oil on the Edge [3]

Review article Gesteiro E, Guijarro L, Sánchez-Muniz FJ, Vidal-Carou MDC, Troncoso A, Venanci L, et al. · · 2019 · cited 43 times (Europe PMC)

Abstract reading summary — source excerpts
Opening excerpt
Internationally recognized Spanish experts in the food industry, nutrition, toxicology, sustainability, and veterinary science met in Madrid on July 2018 to develop a consensus about palm oil (PO) as a food ingredient.
Closing excerpt
Consequently, the European Commission has modified the Contaminants Regulation for GEs and it is still working on 3-MCPDs'.
Interpretation limits
Verbatim excerpts from the authors’ abstract; the closing excerpt may describe a finding, limitation or recommendation. Design, population, effect size and uncertainty have not been independently extracted or appraised. Read the complete abstract and linked paper before interpreting the findings.
Read complete abstract (207 words)

Internationally recognized Spanish experts in the food industry, nutrition, toxicology, sustainability, and veterinary science met in Madrid on July 2018 to develop a consensus about palm oil (PO) as a food ingredient. Their aim was to provide a useful, evidence-based point of reference about PO. Scientific evidence about the role of PO in food safety, nutrition and sustainability was analyzed. Main conclusions were: (1) RSPO foundation responded to the environmental impact of palm crops. The Amsterdam Declaration pursues the use of 100% sustainable PO in Europe by 2020. Awareness about choosing sustainable products will help to maintain local economies and environments in the producing countries; (2) evidence shows that a moderate intake of PO within a healthy diet presents no risks for health. No evidence justifies any change fat intake recommendations; (3) food industry is interested in assuring safe, sustainable and high-quality products. The use of certified sustainable PO is increasing; and (4) there is no evidence associating PO consumption and higher cancer risk, incidence or mortality in humans. Tolerable daily intake (TDI) for toxic contaminants (2-and 3-monochloropropanediols (MCPDs), glycidyl esters (GEs)) have been established by JECFA and EFSA. Consequently, the European Commission has modified the Contaminants Regulation for GEs and it is still working on 3-MCPDs'.

Abstract reproduced from the open-access article under the recorded cc by licence; © the authors. PMID 31454938 · DOI · PMC6770503

Occupancy estimation of wild species in a palm oil plantation using unstructured data [4]

Research article van Strien AJ, Meijaard E, Nardiyono, Suief S, Zaini S · · 2026 · cited 1 times (Europe PMC)

Abstract reading summary — source excerpts
Opening excerpt
In 2020-2024, plantation workers at a large oil palm plantation in West Kalimantan recorded sightings of wild species of several species groups.
Closing excerpt
Although the shortcomings mentioned turned out not to distort our results, the occupancy estimates were imprecise for many study species because of low detection rates, and extra efforts are needed to improve that.
Interpretation limits
Verbatim excerpts from the authors’ abstract; the closing excerpt may describe a finding, limitation or recommendation. Design, population, effect size and uncertainty have not been independently extracted or appraised. Read the complete abstract and linked paper before interpreting the findings.
Read complete abstract (243 words)

In 2020-2024, plantation workers at a large oil palm plantation in West Kalimantan recorded sightings of wild species of several species groups. They did not use a standardized field method and produced no comprehensive reports but recorded only one or a few species per visit. Such unstructured data are generally viewed as challenging for statistical analysis. Here, we used occupancy models to estimate what proportion of spatial units (both non-natural and forest) a given species occupied annually in the plantation. We tested models with different covariates for species for which most data were available: 13 birds, 3 reptiles and 7 mammals, among which the iconic Orangutan (Pongo pygmaeus). For each species, the model which best fitted the data was selected. Two shortcomings in our data complicated the analyses. First, occupancy models require detection and non-detection records, but because no fixed species lists were used, there is no unique way to generate non-detections. We generated non-detection records in several ways and ran the models again to evaluate the consequences for occupancy estimates. Second, imbalances in sampling may occur because of a lack of sampling design to select study sites. Most concerning are sites surveyed only once in 2020-2024. We ran the models without those sites to examine whether results were different. Although the shortcomings mentioned turned out not to distort our results, the occupancy estimates were imprecise for many study species because of low detection rates, and extra efforts are needed to improve that.

Abstract reproduced from the open-access article under the recorded cc by licence; © the authors. PMID 41628261 · DOI · PMC12863681

Key reviews and meta-analyses

The most cited review-type papers among PubMed’s best-match results for this heading, listed with bibliographic details only. Follow the links for the full text and access terms.

  • Research article The environmental impacts of palm oil in context [5]
    Meijaard E, Brooks TM, Carlson KM, Slade EM, Garcia-Ulloa J, Gaveau DLA, et al. · Nat Plants · 2020 · cited 87 times (Europe PMC)
  • Research article Alzheimer's Disease and Type 2 Diabetes Mellitus: The Use of MCT Oil and a Ketogenic Diet [6]
    Takeishi J, Tatewaki Y, Nakase T, Takano Y, Tomita N, Yamamoto S, et al. · Int J Mol Sci · 2021 · cited 37 times (Europe PMC)
  • Research article The palm oil industry and noncommunicable diseases [7]
    Kadandale S, Marten R, Smith R · Bull World Health Organ · 2019 · cited 37 times (Europe PMC)
  • Research article Health-promoting effects of red palm oil: evidence from animal and human studies [8]
    Loganathan R, Subramaniam KM, Radhakrishnan AK, Choo YM, Teng KT · Nutr Rev · 2017 · cited 34 times (Europe PMC)
  • Research article Safety and Neuroprotective Efficacy of Palm Oil and Tocotrienol-Rich Fraction from Palm Oil: A Systematic Review [9]
    Ismail M, Alsalahi A, Imam MU, Ooi J, Khaza'ai H, Aljaberi MA, et al. · Nutrients · 2020 · cited 31 times (Europe PMC)
  • Research article Biochemical properties, nutritional values, health benefits and sustainability of palm oil [10]
    Absalome MA, Massara CC, Alexandre AA, Gervais K, Chantal GG, Ferdinand D, et al. · Biochimie · 2020 · cited 29 times (Europe PMC)

References

  1. Ismail SR, Maarof SK, Siedar Ali S, Ali A. Systematic review of palm oil consumption and the risk of cardiovascular disease. . 2018. PMID 29489910 · DOI · PMC5831100
  2. Chong WT, Tan CP, Cheah YK, B Lajis AF, Habi Mat Dian NL, Kanagaratnam S, et al.. Optimization of process parameters in preparation of tocotrienol-rich red palm oil-based nanoemulsion stabilized by Tween80-Span 80 using response surface methodology. . 2018. PMID 30142164 · DOI · PMC6108518
  3. Gesteiro E, Guijarro L, Sánchez-Muniz FJ, Vidal-Carou MDC, Troncoso A, Venanci L, et al.. Palm Oil on the Edge. . 2019. PMID 31454938 · DOI · PMC6770503
  4. van Strien AJ, Meijaard E, Nardiyono, Suief S, Zaini S. Occupancy estimation of wild species in a palm oil plantation using unstructured data. . 2026. PMID 41628261 · DOI · PMC12863681
  5. Meijaard E, Brooks TM, Carlson KM, Slade EM, Garcia-Ulloa J, Gaveau DLA, et al.. The environmental impacts of palm oil in context. Nat Plants. 2020. PMID 33299148 · DOI
  6. Takeishi J, Tatewaki Y, Nakase T, Takano Y, Tomita N, Yamamoto S, et al.. Alzheimer's Disease and Type 2 Diabetes Mellitus: The Use of MCT Oil and a Ketogenic Diet. Int J Mol Sci. 2021. PMID 34830192 · DOI · PMC8624628
  7. Kadandale S, Marten R, Smith R. The palm oil industry and noncommunicable diseases. Bull World Health Organ. 2019. PMID 30728618 · DOI · PMC6357563
  8. Loganathan R, Subramaniam KM, Radhakrishnan AK, Choo YM, Teng KT. Health-promoting effects of red palm oil: evidence from animal and human studies. Nutr Rev. 2017. PMID 28158744 · DOI
  9. Ismail M, Alsalahi A, Imam MU, Ooi J, Khaza'ai H, Aljaberi MA, et al.. Safety and Neuroprotective Efficacy of Palm Oil and Tocotrienol-Rich Fraction from Palm Oil: A Systematic Review. Nutrients. 2020. PMID 32085610 · DOI · PMC7071496
  10. Absalome MA, Massara CC, Alexandre AA, Gervais K, Chantal GG, Ferdinand D, et al.. Biochemical properties, nutritional values, health benefits and sustainability of palm oil. Biochimie. 2020. PMID 32966855 · DOI

About this article

Sources
NLM Medical Subject Headings (definition, synonyms); NCBI PubMed (counts, identifiers); Europe PMC (open-access abstracts and citation counts).
Verification
Every reference was resolved against PubMed on 2026-10-31; title, year and DOI matched.
Review state
automated source verified; no human expert review has been recorded yet.
Version
1, last updated 2026-10-31.

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At a glance

2,389
PubMed records on this heading
32%
published since 2020
135
review articles
111
randomized trials
10
verified references below

Counts come from PubMed on 2026-10-31; they show how much has been written, not how strong the evidence is.

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