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Eustachian Tube

Anatomy and Physiology · NLM MeSH · updated 2026-10-31 · version 1

Citations verified against PubMedNot yet clinician-reviewed10 referencesApproximately 4 min read

A narrow passageway that connects the upper part of the throat to the tympanic cavity.

Table of Contents

1. Definition2. Research landscape3. Reading the evidence4. Open-access studies5. Key reviews6. References7. About this article

Definition and research guide

This page combines a MeSH definition, publication statistics and selected research abstracts. It is a starting point for reading the literature, not a medical textbook or a systematic evidence review.

Content available: 4 complete abstracts (817 words), 10 references. Full article text is not stored or reproduced here; follow the PMID, DOI or PMC links to read the original sources and their access terms.

Definition

A narrow passageway that connects the upper part of the throat to the tympanic cavity.

Definition: NLM Medical Subject Headings (MeSH) scope note (Public domain (U.S. National Library of Medicine); attribution requested). View the MeSH record.

Also known as: Eustachian Tubes; Tube, Eustachian; Tubes, Eustachian; Pharyngotympanic Tube; Pharyngotympanic Tubes; Tube, Pharyngotympanic; Tubes, Pharyngotympanic; Auditory Tube.

Where it fits in the MeSH classification

Broader topics
Ear, Middle

Related concepts

  • Tympanic Cavity

Research landscape

PubMed indexes 3,877 records tagged with the MeSH heading “Eustachian Tube” (counts retrieved 2026-10-31). 527 of them (13.6%) were published from 2020 onward, and the busiest period so far is through 1999 with 2,145 records.

Reviews account for 328 records (8.5%) and meta-analyses for 22. Randomized controlled trials number 61 (1.6%) as a share of all records on the topic. Randomized trials make up only a small share of this literature, so much of what is known comes from laboratory, observational or descriptive work.

PubMed records by publication periodthrough 1999: 2,145 records; 2000-2009: 508 records; 2010-2019: 697 records; 2020 onward: 527 records2,145through 19995082000-20096972010-20195272020 onward
Records in PubMed indexed with this heading, by publication period. Real counts from NCBI E-utilities; the final period covers only part of the current year. Volume reflects how much has been published, not how strong the evidence is.
Show the data
PeriodRecords
through 19992,145
2000-2009508
2010-2019697
2020 onward527
Share of records by publication typeReviews: 8.5 percent; Meta-analyses: 0.6 percent; Randomized controlled trials: 1.6 percentReviews8.5% (328)Meta-analyses0.6% (22)Randomized controlled trials1.6% (61)
Share of all PubMed records on this heading that carry each publication type. Types overlap with other records, so the shares do not sum to 100%.
Publication-type chart data
Publication types among 3,877 PubMed records
TypeRecordsShare
Reviews3288.5%
Meta-analyses220.6%
Randomized controlled trials611.6%

Method: PubMed query "Eustachian Tube"[MeSH Terms] with publication-type and date filters, retrieved 2026-10-31.

Reading the evidence in anatomy and physiology

Anatomy describes how body structures are built and physiology describes how they normally work, so most findings here are descriptive or mechanistic rather than evidence about treatment. Much of what is known comes from dissection, imaging, tissue studies and experiments in animals, and measurements in healthy volunteers can differ from those in people with disease or at different ages. Normal ranges vary between individuals and populations. Check whether a result was measured in people or in another species, the age and health of the participants, and the method used.

Evidence from open-access studies

These open-access studies come from PubMed’s best-match results for this heading (papers whose main topic it is), ranked here by citation count, with one recent addition. Each abstract is reproduced in full under its recorded open licence so that you can read the authors’ own words. They illustrate the literature; they are not a systematic summary of it. Citation counts measure attention, not reliability or clinical benefit.

Study comparison — selected abstracts, not a systematic review
Study / authorsYearSource label / designEurope PMC citationsLicence / source
Imaging of the Eustachian tube and its function: a systematic review
Smith ME, Scoffings DJ, Tysome JR
2016Systematic review
Design not recorded in structured metadata
76cc by
PMID 26922743 · DOI · PMC4877436
Eustachian tube dysfunction: A diagnostic accuracy study and proposed diagnostic pathway
Smith ME, Takwoingi Y, Deeks J, Alper C, Bance ML, Bhutta MF, et al.
2018Research article
Design not recorded in structured metadata
66cc by
PMID 30408100 · DOI · PMC6224095
Tobacco Smoke Exposure and Eustachian Tube Disorders in US Children and Adolescents
Patel MA, Mener DJ, Garcia-Esquinas E, Navas-Acien A, Agrawal Y, Lin SY
2016Research article
Design not recorded in structured metadata
30cc by
PMID 27711178 · DOI · PMC5053406
Phoneme-cued coaching during standard earpopper® use
Mamikoglu B, Piastro K, Ward R
2026Research article
Design not recorded in structured metadata
0cc by
PMID 41801359 · DOI · PMC13249776

Imaging of the Eustachian tube and its function: a systematic review [1]

Systematic review Smith ME, Scoffings DJ, Tysome JR · · 2016 · cited 76 times (Europe PMC)

Abstract reading summary — source excerpts
Opening excerpt
IntroductionThe Eustachian tube is a complex and inaccessible structure, which maintains middle ear ventilation to facilitate transmission of sound from the tympanic membrane to the cochlea.
Closing excerpt
ConclusionSignificant information can be gained from imaging the Eustachian tube, and as faster acquisition techniques are developed, it is possible that dynamic imaging of tubal opening could play an important role in the assessment of patients with ET dysfunction.
Interpretation limits
Verbatim excerpts from the authors’ abstract; the closing excerpt may describe a finding, limitation or recommendation. Design, population, effect size and uncertainty have not been independently extracted or appraised. Read the complete abstract and linked paper before interpreting the findings.
Read complete abstract (203 words)

IntroductionThe Eustachian tube is a complex and inaccessible structure, which maintains middle ear ventilation to facilitate transmission of sound from the tympanic membrane to the cochlea. A renewed interest in treatments for eustachian tube dysfunction has led to a demand for methods of imaging the Eustachian tube, and assessing tube opening non-invasively. This review aims to summarise the use of imaging in the anatomical assessment of the Eustachian tube, and to explore how radiological techniques can be used to assess tube function.MethodsA systematic review of the literature was performed with narrative data analysis.ResultsWith high-resolution images, the soft and bony anatomy of the Eustachian tube can be assessed in detail. CT and MRI are best suited to identifying features associated with obstructive or patulous Eustachian tube dysfunction, though true assessments of function have only been achieved with contrast enhanced radiographs and scintigraphy. A single modality has yet to provide a complete assessment. No test has entered routine clinical use, but further development and research is underway.ConclusionSignificant information can be gained from imaging the Eustachian tube, and as faster acquisition techniques are developed, it is possible that dynamic imaging of tubal opening could play an important role in the assessment of patients with ET dysfunction.

Abstract reproduced from the open-access article under the recorded cc by licence; © the authors. PMID 26922743 · DOI · PMC4877436

Eustachian tube dysfunction: A diagnostic accuracy study and proposed diagnostic pathway [2]

Research article Smith ME, Takwoingi Y, Deeks J, Alper C, Bance ML, Bhutta MF, et al. · · 2018 · cited 66 times (Europe PMC)

Abstract reading summary — source excerpts
Opening excerpt
Background and aimsEustachian tube dysfunction (ETD) is a commonly diagnosed disorder of Eustachian tube opening and closure, which may be associated with severe symptoms and middle ear disease.
Closing excerpt
Currently diagnostic uncertainty exists for some patients who appear to have intermittent ETD clinically, but have negative index test results.
Interpretation limits
Verbatim excerpts from the authors’ abstract; the closing excerpt may describe a finding, limitation or recommendation. Design, population, effect size and uncertainty have not been independently extracted or appraised. Read the complete abstract and linked paper before interpreting the findings.
Read complete abstract (296 words)

Background and aimsEustachian tube dysfunction (ETD) is a commonly diagnosed disorder of Eustachian tube opening and closure, which may be associated with severe symptoms and middle ear disease. Currently the diagnosis of obstructive and patulous forms of ETD is primarily based on non-specific symptoms or examination findings, rather than measurement of the underlying function of the Eustachian tube. This has proved problematic when selecting patients for treatment, and when designing trial inclusion criteria and outcomes. This study aims to determine the correlation and diagnostic value of various tests of ET opening and patient reported outcome measures (PROMs), in order to generate a recommended diagnostic pathway for ETD.MethodsIndex tests included two PROMs and 14 tests of ET opening (nine for obstructive, five for patulous ETD). In the absence of an accepted reference standard two methods were adopted to establish index test accuracy: expert panel diagnosis and latent class analysis. Index test results were assessed with Pearson correlation and principle component analysis, and test accuracy was determined. Logistic regression models assessed the predictive value of grouped test results.ResultsThe expert panel diagnosis and PROMs results correlated with each other, but not with ET function measured by tests of ET opening. All index tests were found to be feasible in clinic, and acceptable to patients. PROMs had very poor specificity, and no diagnostic value. Combining the results of tests of ET function appeared beneficial. The latent class model suggested tympanometry, sonotubometry and tubomanometry have the best diagnostic performance for obstructive ETD, and these are included in a proposed diagnostic pathway.ConclusionsETD should be diagnosed on the basis of clinical assessment and tests of ET opening, as PROMs have no diagnostic value. Currently diagnostic uncertainty exists for some patients who appear to have intermittent ETD clinically, but have negative index test results.

Abstract reproduced from the open-access article under the recorded cc by licence; © the authors. PMID 30408100 · DOI · PMC6224095

Tobacco Smoke Exposure and Eustachian Tube Disorders in US Children and Adolescents [3]

Research article Patel MA, Mener DJ, Garcia-Esquinas E, Navas-Acien A, Agrawal Y, Lin SY · · 2016 · cited 30 times (Europe PMC)

Abstract reading summary — source excerpts
Opening excerpt
ObjectivesTo describe the association between active, environmental tobacco smoke (ETS) exposure and the prevalence of eustachian tube dysfunction (ETD) in the U.
Closing excerpt
ConclusionThese data suggest that children and adolescents exposed to high concentrations of ETS may have an increased prevalence of ETD.
Interpretation limits
Verbatim excerpts from the authors’ abstract; the closing excerpt may describe a finding, limitation or recommendation. Design, population, effect size and uncertainty have not been independently extracted or appraised. Read the complete abstract and linked paper before interpreting the findings.
Read complete abstract (179 words)

ObjectivesTo describe the association between active, environmental tobacco smoke (ETS) exposure and the prevalence of eustachian tube dysfunction (ETD) in the U.S. pediatric population.Study designCross-sectional.SettingU.S. representative demographic and audiometric data from the National Health and Nutrition Examination Survey (NHANES);2005-2010.Subjects and methodsThe study consisted of 2,977 children aged 12-19 years. ETD was defined as middle ear pressure ResultsThe prevalence of ETD was 6.1%. After multivariate adjustment for age, sex, body mass index, education level, ethnicity, or having a cold, sinus problem or earache during the last 24 hours, compared to unexposed children, the odds ratios (95% confidence interval) of ETD for those exposed to ETS ages 12-15 in the first, second and third tertile of cotinine concentrations were, respectively, 1.38 (0.53-3.60), 0.99 (0.53-3.60) and 2.67 (1.12-6.34). Similarly, the odds ratios (95% confidence interval) of ETD for those exposed to ETS ages 16-19 in the first, second and third tertile of cotinine concentrations were, respectively, 1.28 (0.48-3.41), 0.99 (0.40-2.48) and 2.86 (1.19-6.88).ConclusionThese data suggest that children and adolescents exposed to high concentrations of ETS may have an increased prevalence of ETD.

Abstract reproduced from the open-access article under the recorded cc by licence; © the authors. PMID 27711178 · DOI · PMC5053406

Phoneme-cued coaching during standard earpopper® use [4]

Research article Mamikoglu B, Piastro K, Ward R · · 2026

Abstract reading summary — source excerpts
Opening excerpt
This technical note describes a standardized coaching method that integrates a simple phoneme-based cue into standard EarPopper® use, without altering device settings, airflow, or dosing.
Closing excerpt
Clinical effectiveness has not been formally tested in a comparative study; the technique is presented as a proposed coaching adjunct to standard device use.
Interpretation limits
Verbatim excerpts from the authors’ abstract; the closing excerpt may describe a finding, limitation or recommendation. Design, population, effect size and uncertainty have not been independently extracted or appraised. Read the complete abstract and linked paper before interpreting the findings.
Read complete abstract (139 words)

This technical note describes a standardized coaching method that integrates a simple phoneme-based cue into standard EarPopper® use, without altering device settings, airflow, or dosing. The technique is intended to facilitate coordination between swallowing and soft-palate elevation during positive nasopharyngeal insufflation, a prerequisite for Eustachian tube (ET) opening. Explicit procedural guidance is provided, including patient selection, contraindications, step-by-step technique, the number of insufflations-swallow cycles per session, clinic onboarding, a clinic-first followed by home-use protocol, troubleshooting, and suggested monitoring tools. This article does not present outcome data or claim clinical efficacy; the technique is proposed as a behavioral coaching adjunct consistent with established concepts of ET physiology and fully compliant with the manufacturer's Instructions for Use. Clinical effectiveness has not been formally tested in a comparative study; the technique is presented as a proposed coaching adjunct to standard device use.

Abstract reproduced from the open-access article under the recorded cc by licence; © the authors. PMID 41801359 · DOI · PMC13249776

Key reviews and meta-analyses

The most cited review-type papers among PubMed’s best-match results for this heading, listed with bibliographic details only. Follow the links for the full text and access terms.

  • Research article Eustachian tube dysfunction: consensus statement on definition, types, clinical presentation and diagnosis [5]
    Schilder AG, Bhutta MF, Butler CC, Holy C, Levine LH, Kvaerner KJ, et al. · Clin Otolaryngol · 2015 · cited 247 times (Europe PMC)
  • Research article Eustachian tube function and the middle ear [6]
    Seibert JW, Danner CJ · Otolaryngol Clin North Am · 2006 · cited 129 times (Europe PMC)
  • Research article Anatomy and physiology of eustachian tube and middle ear related to otitis media [7]
    Bluestone CD, Doyle WJ · J Allergy Clin Immunol · 1988 · cited 123 times (Europe PMC)
  • Research article Otitis media and eustachian tube dysfunction: connection to allergic rhinitis [8]
    Fireman P · J Allergy Clin Immunol · 1997 · cited 116 times (Europe PMC)
  • Research article Pathogenesis of otitis media: role of eustachian tube [9]
    Bluestone CD · Pediatr Infect Dis J · 1996 · cited 114 times (Europe PMC)
  • Research article Middle ear and auditory tube: middle ear clearance, gas exchange, and pressure regulation [10]
    Sadé J, Ar A · Otolaryngol Head Neck Surg · 1997 · cited 96 times (Europe PMC)

References

  1. Smith ME, Scoffings DJ, Tysome JR. Imaging of the Eustachian tube and its function: a systematic review. . 2016. PMID 26922743 · DOI · PMC4877436
  2. Smith ME, Takwoingi Y, Deeks J, Alper C, Bance ML, Bhutta MF, et al.. Eustachian tube dysfunction: A diagnostic accuracy study and proposed diagnostic pathway. . 2018. PMID 30408100 · DOI · PMC6224095
  3. Patel MA, Mener DJ, Garcia-Esquinas E, Navas-Acien A, Agrawal Y, Lin SY. Tobacco Smoke Exposure and Eustachian Tube Disorders in US Children and Adolescents. . 2016. PMID 27711178 · DOI · PMC5053406
  4. Mamikoglu B, Piastro K, Ward R. Phoneme-cued coaching during standard earpopper® use. . 2026. PMID 41801359 · DOI · PMC13249776
  5. Schilder AG, Bhutta MF, Butler CC, Holy C, Levine LH, Kvaerner KJ, et al.. Eustachian tube dysfunction: consensus statement on definition, types, clinical presentation and diagnosis. Clin Otolaryngol. 2015. PMID 26347263 · DOI · PMC4600223
  6. Seibert JW, Danner CJ. Eustachian tube function and the middle ear. Otolaryngol Clin North Am. 2006. PMID 17097443 · DOI
  7. Bluestone CD, Doyle WJ. Anatomy and physiology of eustachian tube and middle ear related to otitis media. J Allergy Clin Immunol. 1988. PMID 3286738 · DOI
  8. Fireman P. Otitis media and eustachian tube dysfunction: connection to allergic rhinitis. J Allergy Clin Immunol. 1997. PMID 9042072 · DOI
  9. Bluestone CD. Pathogenesis of otitis media: role of eustachian tube. Pediatr Infect Dis J. 1996. PMID 8866795 · DOI
  10. Sadé J, Ar A. Middle ear and auditory tube: middle ear clearance, gas exchange, and pressure regulation. Otolaryngol Head Neck Surg. 1997. PMID 9141402 · DOI

About this article

Sources
NLM Medical Subject Headings (definition, synonyms); NCBI PubMed (counts, identifiers); Europe PMC (open-access abstracts and citation counts).
Verification
Every reference was resolved against PubMed on 2026-10-31; title, year and DOI matched.
Review state
automated source verified; no human expert review has been recorded yet.
Version
1, last updated 2026-10-31.

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At a glance

3,877
PubMed records on this heading
14%
published since 2020
328
review articles
61
randomized trials
10
verified references below

Counts come from PubMed on 2026-10-31; they show how much has been written, not how strong the evidence is.

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