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Fibula

Anatomy and Physiology · NLM MeSH · updated 2026-10-31 · version 1

Citations verified against PubMedNot yet clinician-reviewed10 referencesApproximately 5 min read

The bone of the lower leg lateral to and smaller than the tibia.

Table of Contents

1. Definition2. Research landscape3. Reading the evidence4. Open-access studies5. Key reviews6. References7. About this article

Definition and research guide

This page combines a MeSH definition, publication statistics and selected research abstracts. It is a starting point for reading the literature, not a medical textbook or a systematic evidence review.

Content available: 4 complete abstracts (979 words), 10 references. Full article text is not stored or reproduced here; follow the PMID, DOI or PMC links to read the original sources and their access terms.

Definition

The bone of the lower leg lateral to and smaller than the tibia. In proportion to its length, it is the most slender of the long bones.

Definition: NLM Medical Subject Headings (MeSH) scope note (Public domain (U.S. National Library of Medicine); attribution requested). View the MeSH record.

Also known as: Fibulas.

Where it fits in the MeSH classification

Broader topics
Leg Bones

Research landscape

PubMed indexes 10,489 records tagged with the MeSH heading “Fibula” (counts retrieved 2026-10-31). 1,729 of them (16.5%) were published from 2020 onward, and the busiest period so far is through 1999 with 4,441 records.

Reviews account for 666 records (6.3%) and meta-analyses for 73. Randomized controlled trials number 83 (0.8%) as a share of all records on the topic. Randomized trials make up only a small share of this literature, so much of what is known comes from laboratory, observational or descriptive work.

PubMed records by publication periodthrough 1999: 4,441 records; 2000-2009: 1,760 records; 2010-2019: 2,559 records; 2020 onward: 1,729 records4,441through 19991,7602000-20092,5592010-20191,7292020 onward
Records in PubMed indexed with this heading, by publication period. Real counts from NCBI E-utilities; the final period covers only part of the current year. Volume reflects how much has been published, not how strong the evidence is.
Show the data
PeriodRecords
through 19994,441
2000-20091,760
2010-20192,559
2020 onward1,729
Share of records by publication typeReviews: 6.3 percent; Meta-analyses: 0.7 percent; Randomized controlled trials: 0.8 percentReviews6.3% (666)Meta-analyses0.7% (73)Randomized controlled trials0.8% (83)
Share of all PubMed records on this heading that carry each publication type. Types overlap with other records, so the shares do not sum to 100%.
Publication-type chart data
Publication types among 10,489 PubMed records
TypeRecordsShare
Reviews6666.3%
Meta-analyses730.7%
Randomized controlled trials830.8%

Method: PubMed query "Fibula"[MeSH Terms] with publication-type and date filters, retrieved 2026-10-31.

Reading the evidence in anatomy and physiology

Anatomy describes how body structures are built and physiology describes how they normally work, so most findings here are descriptive or mechanistic rather than evidence about treatment. Much of what is known comes from dissection, imaging, tissue studies and experiments in animals, and measurements in healthy volunteers can differ from those in people with disease or at different ages. Normal ranges vary between individuals and populations. Check whether a result was measured in people or in another species, the age and health of the participants, and the method used.

Evidence from open-access studies

These open-access studies come from PubMed’s best-match results for this heading (papers whose main topic it is), ranked here by citation count, with one recent addition. Each abstract is reproduced in full under its recorded open licence so that you can read the authors’ own words. They illustrate the literature; they are not a systematic summary of it. Citation counts measure attention, not reliability or clinical benefit.

Study comparison — selected abstracts, not a systematic review
Study / authorsYearSource label / designEurope PMC citationsLicence / source
Virtual Planning and 3D printing modeling for mandibular reconstruction with fibula free flap
Ren W, Gao L, Li S, Chen C, Li F, Wang Q, et al.
2018Research article
Design not recorded in structured metadata
68cc by
PMID 29680849 · DOI · PMC5945234
Three-dimensional analysis of shape variations and symmetry of the fibula, tibia, calcaneus and talus
Tümer N, Arbabi V, Gielis WP, de Jong PA, Weinans H, Tuijthof GJM, et al.
2019Research article
Design not recorded in structured metadata
49cc by
PMID 30393864 · DOI · PMC6284442
Complication of osteo reconstruction by utilizing free vascularized fibular bone graft
Ou Q, Wu P, Zhou Z, Pan D, Tang JY
2020Review article
Design not recorded in structured metadata
39cc by
PMID 33008361 · DOI · PMC7531124
Simultaneous Bi-Jaw Reconstruction: Double Free Fibula Flap Following Resection of Synchronous Oral Malignancy
Khan S, Saini V, Singh V, Gulia A
2026Research article
Design not recorded in structured metadata
0cc by
PMID 41887917 · DOI · PMC13595452

Virtual Planning and 3D printing modeling for mandibular reconstruction with fibula free flap [1]

Research article Ren W, Gao L, Li S, Chen C, Li F, Wang Q, et al. · · 2018 · cited 68 times (Europe PMC)

Abstract reading summary — source excerpts
Opening excerpt
BackgroundThis study was to evaluate the use of virtual planning and 3D printing modeling in mandibular reconstruction and compare the operation time and surgical outcome of this technique with conventional method.
Closing excerpt
we believe that this technology for mandibular reconstruction in selected patients will become a used method and improve the quality of reconstruction.
Interpretation limits
Verbatim excerpts from the authors’ abstract; the closing excerpt may describe a finding, limitation or recommendation. Design, population, effect size and uncertainty have not been independently extracted or appraised. Read the complete abstract and linked paper before interpreting the findings.
Read complete abstract (250 words)

BackgroundThis study was to evaluate the use of virtual planning and 3D printing modeling in mandibular reconstruction and compare the operation time and surgical outcome of this technique with conventional method.Material and methodsBetween 2014 and 2017, 15 patients underwent vascularized fibula flap mandibular reconstruction using virtual planning and 3D printing modeling. Titanium plates were pre-bent using the models and cutting guides were used for osteotomies. 15 patients who underwent mandibular reconstruction using fibula flap without aid of virtual planning and 3D printing models were selected as control group. The operation time was recorded and compared in two groups. Accuracy of reconstruction was measured by superimposing the preoperative image onto the postoperative image of mandible. The selected bony landmark, distance and angle were measured.ResultsThe mean total operation time and reconstruction time were 1.60±0.37 and 5.54±0.50 hours in computer-assisted group, respectively; These were 2.58±0.45 and 6.54±0.70 hours in conventional group, respectively. Both operation time and reconstruction time were shorter in computer-assisted group. The difference between the preoperative and postoperative intercondylar distances, intergonial angle distances, anteroposterior distances and gonial angles were 2.92±1.15 and 4.48±1.41mm, 2.93±1.19 and 4.79±1.48mm, 4.31±1.24 and 5.61±1.41mm, 3.85±1.68° and 5.88±2.12° in the computer-assisted and conventional group, respectively. The differences between the preoperative and postoperative mandible is smaller in the computer-assisted group.ConclusionsVirtual planning and 3D printing modeling have the potential to increase mandibular reconstruction accuracy and reduce operation time. we believe that this technology for mandibular reconstruction in selected patients will become a used method and improve the quality of reconstruction.

Abstract reproduced from the open-access article under the recorded cc by licence; © the authors. PMID 29680849 · DOI · PMC5945234

Three-dimensional analysis of shape variations and symmetry of the fibula, tibia, calcaneus and talus [2]

Research article Tümer N, Arbabi V, Gielis WP, de Jong PA, Weinans H, Tuijthof GJM, et al. · · 2019 · cited 49 times (Europe PMC)

Abstract reading summary — source excerpts
Opening excerpt
The bones forming the talocrural joint (TCJ) and subtalar joint (STJ) are often assumed to be bilaterally symmetric.
Closing excerpt
This result suggests that the shape symmetry assumption could be violated for some specific shape variations in the fibula and tibia.
Interpretation limits
Verbatim excerpts from the authors’ abstract; the closing excerpt may describe a finding, limitation or recommendation. Design, population, effect size and uncertainty have not been independently extracted or appraised. Read the complete abstract and linked paper before interpreting the findings.
Read complete abstract (388 words)

The bones forming the talocrural joint (TCJ) and subtalar joint (STJ) are often assumed to be bilaterally symmetric. Therefore, the contralateral limb (i.e. the fibula, tibia, calcaneus and talus) is used as a template or an intra-subject control in clinical and research practice. However, the validity of the symmetry assumption is controversial, because insufficient information is available on the shape variations and bilateral (a)symmetry of the fibula, tibia, calcaneus and talus. Using three-dimensional spatially dense sampled representations of bone shapes extracted from bilateral computed tomography scans of 66 individuals (55 male, mean age: 61 ± 10 years; 11 female, mean age: 53 ± 15 years), we analyzed whether: (i) similar shape patterns exist in the left and right bones of the same type; (ii) gender has an effect on bone shape variations; (iii) intra-subject shape variation is smaller than that of inter-subject for a given shape variance direction. For the first set of analyses, all left and right instances of the same type of bone were considered as two separate groups, and statistically compared with each other on multiple aspects including group location (central tendency), variance-covariance scale (dispersion) and orientation (covariance structure) using distance-based permutational tests. For the second and third sets of analyses, all left and right bones of the same type were pooled into one group, and shape variations in the TCJ and STJ bones were extracted using principal component analysis. The effects of gender on age-adjusted bone shape differences were assessed using an analysis of covariance. Moreover, intra-class correlation was employed to evaluate intra- and inter-subject bone shape variations. For each bone type, both sides had similar shape patterns (Ppermutational -values > 0.05). After Bonferroni adjustment, gender led to shape differences, which were mainly in the lateral and medial condyles of the tibia (P = 0.003), the length and height of the calcaneus (P < 0.001), the posterior and anterior talar articular surfaces of the calcaneus (P = 0.001), and in the posterior aspect of the talus (P = 0.001). Intra-subject shape variations in the tibial tuberosity together with the diameter of the tibia, and the curvature of the fibula shaft and the diameter of the fibula were as high as those of inter-subject. This result suggests that the shape symmetry assumption could be violated for some specific shape variations in the fibula and tibia.

Abstract reproduced from the open-access article under the recorded cc by licence; © the authors. PMID 30393864 · DOI · PMC6284442

Complication of osteo reconstruction by utilizing free vascularized fibular bone graft [3]

Review article Ou Q, Wu P, Zhou Z, Pan D, Tang JY · · 2020 · cited 39 times (Europe PMC)

Abstract reading summary — source excerpts
Opening excerpt
The success of free vascularized fibular bone graft (FVFBG) has accelerated the osteo reconstruction which results from trauma, resection of a tumor or an infectious bone segment, or correction of congenital deformity.
Closing excerpt
In conclusion, FVFBG, though a mature technique, needs further deep and comprehensive study and maybe device-based assistance to achieve better reconstructive effect and minimize donor-site damage.
Interpretation limits
Verbatim excerpts from the authors’ abstract; the closing excerpt may describe a finding, limitation or recommendation. Design, population, effect size and uncertainty have not been independently extracted or appraised. Read the complete abstract and linked paper before interpreting the findings.
Read complete abstract (246 words)

The success of free vascularized fibular bone graft (FVFBG) has accelerated the osteo reconstruction which results from trauma, resection of a tumor or an infectious bone segment, or correction of congenital deformity. But the complication behind should not be overlooked. The failure could necessitate a second surgery, which prolong the rehabilitation period and produce further health cost. Worst, the patients may suffer a permanent impaired ankle function, or a sustained morpho-functional loss on reconstructive area which are hard to save. To provide an overview of the complication related to reconstruction by FVFBG, a narrative review is conducted to identify the complications including their types and rates, the contributing factors, the approaches to measure and the techniques to avoid. Methodologically, by quick research on Pubmed and abstract reading of reviews, we characterize five reconstructive areas where FVFBG were most frequently applied: extremities, mandible, spine, osteonecrosis of femoral head, and penile. Following, the complications on different reconstructive areas are retrieved, studied and presented in five (or more specifically, six) separate sections. By the way, meaningful difference between FVFBG and other bone flap was presented in a few words if necessary. Donor-site morbidities were studied and summarized as a whole. In these literatures, the evidences documented on limb and mandibular reconstruction have the fullest detail, followed by the spine and lastly the penile. In conclusion, FVFBG, though a mature technique, needs further deep and comprehensive study and maybe device-based assistance to achieve better reconstructive effect and minimize donor-site damage.

Abstract reproduced from the open-access article under the recorded cc by licence; © the authors. PMID 33008361 · DOI · PMC7531124

Simultaneous Bi-Jaw Reconstruction: Double Free Fibula Flap Following Resection of Synchronous Oral Malignancy [4]

Research article Khan S, Saini V, Singh V, Gulia A · · 2026

Abstract reading summary — source excerpts
Opening excerpt
BackgroundSimultaneous reconstruction of extensive maxillary and mandibular defects in oncological cases is a complex surgical challenge.
Closing excerpt
ConclusionThis case describes the first reported use of double fibular flap for simultaneous upper and lower jaw reconstruction in a case of synchronous oral malignancy.
Interpretation limits
Verbatim excerpts from the authors’ abstract; the closing excerpt may describe a finding, limitation or recommendation. Design, population, effect size and uncertainty have not been independently extracted or appraised. Read the complete abstract and linked paper before interpreting the findings.
Read complete abstract (95 words)

BackgroundSimultaneous reconstruction of extensive maxillary and mandibular defects in oncological cases is a complex surgical challenge.MethodsWe report a case of a 56-year-old female with synchronous oral malignancy involving upper and lower alveolus. Simultaneous double free fibula osteo-cutaneous flaps were used for reconstruction of upper and lower alveolus reconstruction.ResultWe were able to circumvent this challenging case with the use of double fibular free flaps. The reconstruction successfully restored form, function, and aesthetics.ConclusionThis case describes the first reported use of double fibular flap for simultaneous upper and lower jaw reconstruction in a case of synchronous oral malignancy.

Abstract reproduced from the open-access article under the recorded cc by licence; © the authors. PMID 41887917 · DOI · PMC13595452

Key reviews and meta-analyses

The most cited review-type papers among PubMed’s best-match results for this heading, listed with bibliographic details only. Follow the links for the full text and access terms.

  • Research article Anatomy of the distal tibiofibular syndesmosis in adults: a pictorial essay with a multimodality approach [5]
    Hermans JJ, Beumer A, de Jong TA, Kleinrensink GJ · J Anat · 2010 · cited 176 times (Europe PMC)
  • Research article The timing of ankle fracture surgery and the effect on infectious complications; a case series and systematic review of the literature [6]
    Schepers T, De Vries MR, Van Lieshout EM, Van der Elst M · Int Orthop · 2013 · cited 139 times (Europe PMC)
  • Research article Fibular a/hypoplasia: review and documentation of the fibular developmental field [7]
    Lewin SO, Opitz JM · Am J Med Genet Suppl · 1986 · cited 102 times (Europe PMC)
  • Research article Intercalary segmental reconstruction after bone tumor resection [8]
    Fuchs B, Ossendorf C, Leerapun T, Sim FH · Eur J Surg Oncol · 2008 · cited 95 times (Europe PMC)
  • Research article Harnessing the potential of the free fibula osteoseptocutaneous flap in mandible reconstruction [9]
    Wallace CG, Chang YM, Tsai CY, Wei FC · Plast Reconstr Surg · 2010 · cited 86 times (Europe PMC)
  • Research article Computer-Assisted versus Conventional Freehand Mandibular Reconstruction with Fibula Free Flap: A Systematic Review and Meta-Analysis [10]
    Powcharoen W, Yang WF, Yan Li K, Zhu W, Su YX · Plast Reconstr Surg · 2019 · cited 83 times (Europe PMC)

References

  1. Ren W, Gao L, Li S, Chen C, Li F, Wang Q, et al.. Virtual Planning and 3D printing modeling for mandibular reconstruction with fibula free flap. . 2018. PMID 29680849 · DOI · PMC5945234
  2. Tümer N, Arbabi V, Gielis WP, de Jong PA, Weinans H, Tuijthof GJM, et al.. Three-dimensional analysis of shape variations and symmetry of the fibula, tibia, calcaneus and talus. . 2019. PMID 30393864 · DOI · PMC6284442
  3. Ou Q, Wu P, Zhou Z, Pan D, Tang JY. Complication of osteo reconstruction by utilizing free vascularized fibular bone graft. . 2020. PMID 33008361 · DOI · PMC7531124
  4. Khan S, Saini V, Singh V, Gulia A. Simultaneous Bi-Jaw Reconstruction: Double Free Fibula Flap Following Resection of Synchronous Oral Malignancy. . 2026. PMID 41887917 · DOI · PMC13595452
  5. Hermans JJ, Beumer A, de Jong TA, Kleinrensink GJ. Anatomy of the distal tibiofibular syndesmosis in adults: a pictorial essay with a multimodality approach. J Anat. 2010. PMID 21108526 · DOI
  6. Schepers T, De Vries MR, Van Lieshout EM, Van der Elst M. The timing of ankle fracture surgery and the effect on infectious complications; a case series and systematic review of the literature. Int Orthop. 2013. PMID 23288046 · DOI · PMC3580081
  7. Lewin SO, Opitz JM. Fibular a/hypoplasia: review and documentation of the fibular developmental field. Am J Med Genet Suppl. 1986. PMID 3146293 · DOI
  8. Fuchs B, Ossendorf C, Leerapun T, Sim FH. Intercalary segmental reconstruction after bone tumor resection. Eur J Surg Oncol. 2008. PMID 18191363 · DOI
  9. Wallace CG, Chang YM, Tsai CY, Wei FC. Harnessing the potential of the free fibula osteoseptocutaneous flap in mandible reconstruction. Plast Reconstr Surg. 2010. PMID 20048622 · DOI
  10. Powcharoen W, Yang WF, Yan Li K, Zhu W, Su YX. Computer-Assisted versus Conventional Freehand Mandibular Reconstruction with Fibula Free Flap: A Systematic Review and Meta-Analysis. Plast Reconstr Surg. 2019. PMID 31764662 · DOI

About this article

Sources
NLM Medical Subject Headings (definition, synonyms); NCBI PubMed (counts, identifiers); Europe PMC (open-access abstracts and citation counts).
Verification
Every reference was resolved against PubMed on 2026-10-31; title, year and DOI matched.
Review state
automated source verified; no human expert review has been recorded yet.
Version
1, last updated 2026-10-31.

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At a glance

10,489
PubMed records on this heading
16%
published since 2020
666
review articles
83
randomized trials
10
verified references below

Counts come from PubMed on 2026-10-31; they show how much has been written, not how strong the evidence is.

Related topics See all →

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  • TalusAnatomy and Physiology
  • AcetabulumAnatomy and Physiology
  • AcromionAnatomy and Physiology
  • CalcaneusAnatomy and Physiology

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