Skip to content
EvidenceHelixEvidenceLib · Scientific Encyclopedia
⌘ K

Scientific library

EvidenceLib encyclopediaAll articles A–Z2,100Open textbooks2Cancer study catalog458How it is made

My workspace this browser

Saved pages0Notes & annotations0

Recently viewed

Explore by field

Cancer and Oncology107Genetics and Genomics95Neuroscience110Cardiovascular Medicine105Immunology90Pharmacology99Molecular Biology100Infectious Diseases102Rare and Inherited Diseases106Clinical Research98Anatomy and Physiology542Drugs and Chemicals546
Plans & pricingCompare EvidenceHelix workspace plans
Library›EvidenceLib›Anatomy and Physiology›Ankle Joint
Explore more with EvidenceHelix Workspace

Compare studies, analyze evidence and create research reports with premium tools.

Explore Researcher plans

Research reading room

Ankle Joint

Anatomy and Physiology · NLM MeSH · updated 2026-10-31 · version 1

Citations verified against PubMedNot yet clinician-reviewed10 referencesApproximately 6 min read

The joint that is formed by the inferior articular and malleolar articular surfaces of the tibia; the malleolar articular surface of the fibula; and the medial malleolar, lateral malleolar, and superior surfaces of the talus.

Table of Contents

1. Definition2. Research landscape3. Reading the evidence4. Open-access studies5. Key reviews6. References7. About this article

Definition and research guide

This page combines a MeSH definition, publication statistics and selected research abstracts. It is a starting point for reading the literature, not a medical textbook or a systematic evidence review.

Content available: 4 complete abstracts (1,140 words), 10 references. Full article text is not stored or reproduced here; follow the PMID, DOI or PMC links to read the original sources and their access terms.

Definition

The joint that is formed by the inferior articular and malleolar articular surfaces of the tibia; the malleolar articular surface of the fibula; and the medial malleolar, lateral malleolar, and superior surfaces of the talus.

Definition: NLM Medical Subject Headings (MeSH) scope note (Public domain (U.S. National Library of Medicine); attribution requested). View the MeSH record.

Also known as: Ankle Joints; Joint, Ankle; Joints, Ankle; Ankle Syndesmosis; Ankle Syndesmoses; Syndesmosis, Ankle; Articulatio talocruralis; Talocrural Joint.

Where it fits in the MeSH classification

Broader topics
Foot Joints
See also
Ankle

Related concepts

  • Tibia
  • Fibula
  • Talus

Research landscape

PubMed indexes 22,172 records tagged with the MeSH heading “Ankle Joint” (counts retrieved 2026-10-31). 6,289 of them (28.4%) were published from 2020 onward, and the busiest period so far is 2010-2019 with 7,395 records.

Reviews account for 2,208 records (10.0%) and meta-analyses for 249. Randomized controlled trials number 858 (3.9%) as a share of all records on the topic.

PubMed records by publication periodthrough 1999: 4,930 records; 2000-2009: 3,558 records; 2010-2019: 7,395 records; 2020 onward: 6,289 records4,930through 19993,5582000-20097,3952010-20196,2892020 onward
Records in PubMed indexed with this heading, by publication period. Real counts from NCBI E-utilities; the final period covers only part of the current year. Volume reflects how much has been published, not how strong the evidence is.
Show the data
PeriodRecords
through 19994,930
2000-20093,558
2010-20197,395
2020 onward6,289
Share of records by publication typeReviews: 10.0 percent; Meta-analyses: 1.1 percent; Randomized controlled trials: 3.9 percentReviews10.0% (2,208)Meta-analyses1.1% (249)Randomized controlled trials3.9% (858)
Share of all PubMed records on this heading that carry each publication type. Types overlap with other records, so the shares do not sum to 100%.
Publication-type chart data
Publication types among 22,172 PubMed records
TypeRecordsShare
Reviews2,20810.0%
Meta-analyses2491.1%
Randomized controlled trials8583.9%

Method: PubMed query "Ankle Joint"[MeSH Terms] with publication-type and date filters, retrieved 2026-10-31.

Reading the evidence in anatomy and physiology

Anatomy describes how body structures are built and physiology describes how they normally work, so most findings here are descriptive or mechanistic rather than evidence about treatment. Much of what is known comes from dissection, imaging, tissue studies and experiments in animals, and measurements in healthy volunteers can differ from those in people with disease or at different ages. Normal ranges vary between individuals and populations. Check whether a result was measured in people or in another species, the age and health of the participants, and the method used.

Evidence from open-access studies

These open-access studies come from PubMed’s best-match results for this heading (papers whose main topic it is), ranked here by citation count, with one recent addition. Each abstract is reproduced in full under its recorded open licence so that you can read the authors’ own words. They illustrate the literature; they are not a systematic summary of it. Citation counts measure attention, not reliability or clinical benefit.

Study comparison — selected abstracts, not a systematic review
Study / authorsYearSource label / designEurope PMC citationsLicence / source
Effect of proprioceptive neuromuscular facilitation on patients with chronic ankle instability: A systematic review and meta-analysis
Yin Y, Wang J, Lin Q, Luo Y, Liu Y, Sun J
2025Meta-analysis
Design not recorded in structured metadata
16cc by
PMID 39787087 · DOI · PMC11717224
Effectiveness of exercise therapy on chronic ankle instability: a meta-analysis
Zhang C, Luo Z, Wu D, Fei J, Xie T, Su M
2025Meta-analysis
Design not recorded in structured metadata
13cc by
PMID 40188228 · DOI · PMC11972327
Impact of specialized fatigue and backhand smash on the ankle biomechanics of female badminton players
He Z, Liu G, Zhang B, Ye B, Zhu H
2024Research article
Design not recorded in structured metadata
10cc by
PMID 38704481 · DOI · PMC11069527
Mental Health Predictors of Dynamic Balance in Individuals With Chronic Ankle Instability
Jaffri A
2026Research article
Design not recorded in structured metadata
0cc by
PMID 41913085 · DOI · PMC13581079

Effect of proprioceptive neuromuscular facilitation on patients with chronic ankle instability: A systematic review and meta-analysis [1]

Meta-analysis Yin Y, Wang J, Lin Q, Luo Y, Liu Y, Sun J · · 2025 · cited 16 times (Europe PMC)

Abstract reading summary — source excerpts
Opening excerpt
ObjectiveThis study conducts a rigorous meta-analysis of existing literature to rigorously examine the efficacy of Proprioceptive Neuromuscular Facilitation (PNF) in ameliorating functional deficits associated with Chronic Ankle Instability (CAI).
Closing excerpt
Further research is required to substantiate these specific effects.
Interpretation limits
Verbatim excerpts from the authors’ abstract; the closing excerpt may describe a finding, limitation or recommendation. Design, population, effect size and uncertainty have not been independently extracted or appraised. Read the complete abstract and linked paper before interpreting the findings.
Read complete abstract (262 words)

ObjectiveThis study conducts a rigorous meta-analysis of existing literature to rigorously examine the efficacy of Proprioceptive Neuromuscular Facilitation (PNF) in ameliorating functional deficits associated with Chronic Ankle Instability (CAI).MethodsLiterature searches were conducted in multiple databases including China National Knowledge Infrastructure (CNKI), VIP, Wanfang, China Biology Medicine disc (CBM), PubMed, EBSCO (Medline, CINAHL, SPORTDiscus, and Rehabilitation & Sports Medicine Source), Embase, ScienceDirect, ProQuest, Cochrane Library, and Web of Science for randomized controlled trials assessing the effects of Proprioceptive Neuromuscular Facilitation interventions on patients with Chronic Ankle Instability. The publication timeframe spanned from the inception of each database until April 10, 2024. Meta-analysis was performed using STATA 12 software on the included studies.Results① A total of 12 randomized controlled trials were included, encompassing 405 patients with Chronic Ankle Instability, demonstrating a generally high methodological quality of the literature.② Meta-analysis results indicate that compared to the control group, Proprioceptive Neuromuscular Facilitation (PNF) significantly enhanced the balance ability of patients with Chronic Ankle Instability as measured by the Y Balance Test (YBT) (Weighted Mean Difference (WMD) = 3.61, 95% CI [2.65, 4.56], z = 7.42, P0.05), however, the effects of PNF training persisted for a certain period even after cessation of treatment.ConclusionProprioceptive Neuromuscular Facilitation (PNF) can significantly improve balance, muscle strength, and pain in patients with Chronic Ankle Instability (CAI). While PNF has shown improvements in joint position sense and dorsiflexion range of motion for CAI patients, with effects that remain for a period thereafter, these improvements were not significantly different when compared to the control group. Further research is required to substantiate these specific effects.

Abstract reproduced from the open-access article under the recorded cc by licence; © the authors. PMID 39787087 · DOI · PMC11717224

Effectiveness of exercise therapy on chronic ankle instability: a meta-analysis [2]

Meta-analysis Zhang C, Luo Z, Wu D, Fei J, Xie T, Su M · · 2025 · cited 13 times (Europe PMC)

Abstract reading summary — source excerpts
Opening excerpt
Lateral ankle sprains are one of the most common musculoskeletal injuries.
Closing excerpt
This approach holds significant theoretical and practical value for optimizing CAI treatment strategies and enhancing patient outcomes.
Interpretation limits
Verbatim excerpts from the authors’ abstract; the closing excerpt may describe a finding, limitation or recommendation. Design, population, effect size and uncertainty have not been independently extracted or appraised. Read the complete abstract and linked paper before interpreting the findings.
Read complete abstract (360 words)

Lateral ankle sprains are one of the most common musculoskeletal injuries. Up to 70% of individuals who sustain lateral ankle sprains develop chronic ankle instability (CAI). Exercise therapy is considered an effective treatment for patients with CAI. This meta-analysis investigated the efficacy of exercise therapy in CAI patients by reviewing 15 randomized controlled trials (RCTs) involving 586 participants. Databases including PubMed, EMBASE, Cochrane Library, and Web of Science were searched from inception to September 13, 2024. The Cochrane Risk of Bias Tool was used to assess study quality. Meta-analysis, sensitivity analysis, and publication bias analysis were conducted using RevMan 5.3.0 and Stata 18.0 software. The Grading of Recommendations, Assessment, Development, and Evaluations (GRADE) approach was applied to evaluate the quality of evidence. Main outcomes were assessed using the Foot and Ankle Ability Measure (FAAM) and the Star Excursion Balance Test (SEBT). The results demonstrated that exercise therapy significantly improved FAAM-S (MD = 7.98, CI: 4.11 to 11.86, p < 0.0001, I² = 30%). Long-term exercise therapy (over 4 weeks) significantly enhanced FAAM-A (MD = 10.95, CI: 6.60 to 15.29, p < 0.00001, I² = 0%) and dynamic balance ability of ankle joint (SBET-A: MD = 4.83, CI: 1.04 to 8.63, p = 0.01, I² = 62%; SEBT-PM: MD = 6.93, CI: 2.37 to 11.48, p = 0.003, I² = 69%; and SEBT-PL: MD = 8.98, CI: 2.66 to 15.29, p = 0.005, I² = 86%). After categorizing by exercise type, the results indicated that strength training was more effective in improving SEBT-PL (MD = 8.15, CI: 6.09 to 10.21, p < 0.00001, I² = 0%), joint mobilization was more effective in improving SEBT-A (MD = 7.65, CI: 4.93 to 10.37, p < 0.00001, I² = 0%), and proprioceptive training was more effective in improving SEBT-PM (MD = 10.46, CI: 5.27 to 15.65, p < 0.0001, I² = 33%). In conclusion, long-term, multifaceted exercise therapy demonstrates superior rehabilitation efficacy for patients with CAI. Personalized treatment plans, informed by SEBT assessment results, should prioritize targeted interventions such as joint mobilization, strength training, or proprioceptive training. This approach holds significant theoretical and practical value for optimizing CAI treatment strategies and enhancing patient outcomes.

Abstract reproduced from the open-access article under the recorded cc by licence; © the authors. PMID 40188228 · DOI · PMC11972327

Impact of specialized fatigue and backhand smash on the ankle biomechanics of female badminton players [3]

Research article He Z, Liu G, Zhang B, Ye B, Zhu H · · 2024 · cited 10 times (Europe PMC)

Abstract reading summary — source excerpts
Opening excerpt
During fatigued conditions, badminton players may experience adverse effects on their ankle joints during smash landings.
Closing excerpt
Compared with BRJS, BLJS poses a higher risk of lateral ankle sprains after fatigue.
Interpretation limits
Verbatim excerpts from the authors’ abstract; the closing excerpt may describe a finding, limitation or recommendation. Design, population, effect size and uncertainty have not been independently extracted or appraised. Read the complete abstract and linked paper before interpreting the findings.
Read complete abstract (349 words)

During fatigued conditions, badminton players may experience adverse effects on their ankle joints during smash landings. In addition, the risk of ankle injury may vary with different landing strategies. This study aimed to investigate the influence of sport-specific fatigue factors and two backhand smash actions on ankle biomechanical indices. Thirteen female badminton players (age: 21.2 ± 1.9 years; height: 167.1 ± 4.1 cm; weight: 57.3 ± 5.1 kg; BMI: 20.54 ± 1.57 kg/m2) participated in this study. An 8-camera Vicon motion capture system and three Kistler force platforms were used to collect kinematic and kinetic data before and after fatigue for backhand rear-court jump smash (BRJS) and backhand lateral jump smash (BLJS). A 2 × 2 repeated measures analysis of variance was employed to analyze the effects of these smash landing actions and fatigue factors on ankle biomechanical parameters. Fatigue significantly affected the ankle-joint plantarflexion and inversion angles at the initial contact (IC) phase (p < 0.05), with both angles increasing substantially post-fatigue. From a kinetic perspective, fatigue considerably influenced the peak plantarflexion and peak inversion moments at the ankle joint, which resulted in a decrease the former and an increase in the latter after fatigue. The two smash landing actions demonstrated different landing strategies, and significant main effects were observed on the ankle plantarflexion angle, inversion angle, peak dorsiflexion/plantarflexion moment, peak inversion/eversion moment, and peak internal rotation moment (p < 0.05). The BLJS landing had a much greater landing inversion angle, peak inversion moment, and peak internal rotation moment compared with BRJS landing. The interaction effects of fatigue and smash actions significantly affected the muscle force of the peroneus longus (PL), with a more pronounced decrease in the force of the PL muscle post-fatigue in the BLJS action(post-hoc < 0.05). This study demonstrated that fatigue and smash actions, specifically BRJS and BLJS, significantly affect ankle biomechanical parameters. After fatigue, both actions showed a notable increase in IC plantarflexion and inversion angles and peak inversion moments, which may elevate the risk of lateral ankle sprains. Compared with BRJS, BLJS poses a higher risk of lateral ankle sprains after fatigue.

Abstract reproduced from the open-access article under the recorded cc by licence; © the authors. PMID 38704481 · DOI · PMC11069527

Mental Health Predictors of Dynamic Balance in Individuals With Chronic Ankle Instability [4]

Research article Jaffri A · · 2026

Abstract reading summary — source excerpts
Opening excerpt
BackgroundChronic ankle instability (CAI) is linked to impaired dynamic balance and psychological deficits, potentially hindering optimal rehabilitation outcomes.
Closing excerpt
Incorporating mental health assessments into physical rehabilitation may enhance treatment outcomes for individuals with CAI.
Interpretation limits
Verbatim excerpts from the authors’ abstract; the closing excerpt may describe a finding, limitation or recommendation. Design, population, effect size and uncertainty have not been independently extracted or appraised. Read the complete abstract and linked paper before interpreting the findings.
Read complete abstract (169 words)

BackgroundChronic ankle instability (CAI) is linked to impaired dynamic balance and psychological deficits, potentially hindering optimal rehabilitation outcomes. However, the impact of psychological deficits on dynamic balance has not been explored before. Therefore, the aim of this study is to determine whether mental health factors predict dynamic balance performance in individuals with CAI using the Star Excursion Balance Test (SEBT).MethodsThis is a cross-sectional observational study performed in a university setting. Forty individuals with CAI (17 men, 23 women) participated in this study. Assessments included psychological profiles (kinesiophobia, self-reported mental health, self-efficacy, global mental health, and functional status via FAAM-Sport). Dynamic balance was evaluated using the SEBT composite and directional scores.ResultsMultiple linear regression analyses indicated that the SEBT composite score was significantly predicted by self-efficacy, global mental health and TSK-11, explaining 40% of the variance (F-value = 7.82, p ConclusionsThe findings underscore the importance of psychological factors as key predictors of dynamic balance in CAI. Incorporating mental health assessments into physical rehabilitation may enhance treatment outcomes for individuals with CAI.

Abstract reproduced from the open-access article under the recorded cc by licence; © the authors. PMID 41913085 · DOI · PMC13581079

Key reviews and meta-analyses

The most cited review-type papers among PubMed’s best-match results for this heading, listed with bibliographic details only. Follow the links for the full text and access terms.

  • Research article An Updated Model of Chronic Ankle Instability [5]
    Hertel J, Corbett RO · J Athl Train · 2019 · cited 544 times (Europe PMC)
  • Research article The outcome of total ankle replacement: a systematic review and meta-analysis [6]
    Zaidi R, Cro S, Gurusamy K, Siva N, Macgregor A, Henricson A, et al. · Bone Joint J · 2013 · cited 217 times (Europe PMC)
  • Research article Chronic ankle instability is associated with proprioception deficits: A systematic review and meta-analysis [7]
    Xue X, Ma T, Li Q, Song Y, Hua Y · J Sport Health Sci · 2021 · cited 166 times (Europe PMC)
  • Research article A systematic review and meta-analysis of the effect of an ankle-foot orthosis on gait biomechanics after stroke [8]
    Tyson SF, Sadeghi-Demneh E, Nester CJ · Clin Rehabil · 2013 · cited 125 times (Europe PMC)
  • Research article Acute lateral ankle sprain to chronic ankle instability: a pathway of dysfunction [9]
    Miklovic TM, Donovan L, Protzuk OA, Kang MS, Feger MA · Phys Sportsmed · 2018 · cited 106 times (Europe PMC)
  • Research article Concentric evertor strength differences and functional ankle instability: a meta-analysis [10]
    Arnold BL, Linens SW, de la Motte SJ, Ross SE · J Athl Train · 2009 · cited 100 times (Europe PMC)

References

  1. Yin Y, Wang J, Lin Q, Luo Y, Liu Y, Sun J. Effect of proprioceptive neuromuscular facilitation on patients with chronic ankle instability: A systematic review and meta-analysis. . 2025. PMID 39787087 · DOI · PMC11717224
  2. Zhang C, Luo Z, Wu D, Fei J, Xie T, Su M. Effectiveness of exercise therapy on chronic ankle instability: a meta-analysis. . 2025. PMID 40188228 · DOI · PMC11972327
  3. He Z, Liu G, Zhang B, Ye B, Zhu H. Impact of specialized fatigue and backhand smash on the ankle biomechanics of female badminton players. . 2024. PMID 38704481 · DOI · PMC11069527
  4. Jaffri A. Mental Health Predictors of Dynamic Balance in Individuals With Chronic Ankle Instability. . 2026. PMID 41913085 · DOI · PMC13581079
  5. Hertel J, Corbett RO. An Updated Model of Chronic Ankle Instability. J Athl Train. 2019. PMID 31162943 · DOI · PMC6602403
  6. Zaidi R, Cro S, Gurusamy K, Siva N, Macgregor A, Henricson A, et al.. The outcome of total ankle replacement: a systematic review and meta-analysis. Bone Joint J. 2013. PMID 24151270 · DOI
  7. Xue X, Ma T, Li Q, Song Y, Hua Y. Chronic ankle instability is associated with proprioception deficits: A systematic review and meta-analysis. J Sport Health Sci. 2021. PMID 33017672 · DOI · PMC7987558
  8. Tyson SF, Sadeghi-Demneh E, Nester CJ. A systematic review and meta-analysis of the effect of an ankle-foot orthosis on gait biomechanics after stroke. Clin Rehabil. 2013. PMID 23798747 · DOI
  9. Miklovic TM, Donovan L, Protzuk OA, Kang MS, Feger MA. Acute lateral ankle sprain to chronic ankle instability: a pathway of dysfunction. Phys Sportsmed. 2018. PMID 29171312 · DOI
  10. Arnold BL, Linens SW, de la Motte SJ, Ross SE. Concentric evertor strength differences and functional ankle instability: a meta-analysis. J Athl Train. 2009. PMID 19911093 · DOI · PMC2775368

About this article

Sources
NLM Medical Subject Headings (definition, synonyms); NCBI PubMed (counts, identifiers); Europe PMC (open-access abstracts and citation counts).
Verification
Every reference was resolved against PubMed on 2026-10-31; title, year and DOI matched.
Review state
automated source verified; no human expert review has been recorded yet.
Version
1, last updated 2026-10-31.

See how EvidenceLib is built. Spotted an error? Email support@evidencehelix.com.

Evidence strength

EvidenceHelix's computed view of the study designs behind this topic: how common meta-analyses, randomized trials and reviews are, how recent the literature is, and a plain-language reading. It describes the design mix of the literature. It is not a quality appraisal of any study, and it is not medical advice.

Included with the Researcher plan

Reading every article stays free. This computed view is part of the paid plans.

See plans Sign in

Your notes

Notes and highlights stay in this browser only; they are not sent to EvidenceHelix.

Related research topics

  • JointsAnatomy and Physiology
  • Temporomandibular JointAnatomy and Physiology
  • Hip JointAnatomy and Physiology
  • Shoulder JointAnatomy and Physiology
  • Wrist JointAnatomy and Physiology
  • Patellofemoral JointAnatomy and Physiology

All 542 articles in Anatomy and Physiology →

At a glance

22,172
PubMed records on this heading
28%
published since 2020
2,208
review articles
858
randomized trials
10
verified references below

Counts come from PubMed on 2026-10-31; they show how much has been written, not how strong the evidence is.

Related topics See all →

  • JointsAnatomy and Physiology
  • Temporomandibular JointAnatomy and Physiology
  • Hip JointAnatomy and Physiology
  • Shoulder JointAnatomy and Physiology
  • Wrist JointAnatomy and Physiology

My notes & annotations (0)

Nothing yet. Select text and press Highlight, or write a note in the Notes tab. Stored in this browser only.

Sources

  • NLM MeSH record ↗
  • PubMed search used ↗

EvidenceLib is a research-education resource, not medical advice. It does not diagnose, prescribe or recommend starting, stopping or changing any treatment. Talk to a qualified clinician about your own situation. Methods, sources and licences · Legal · Support