Definition and research guide
This page combines a MeSH definition, publication statistics and selected research abstracts. It is a starting point for reading the literature, not a medical textbook or a systematic evidence review.
Content available: 4 complete abstracts (1,098 words), 10 references. Full article text is not stored or reproduced here; follow the PMID, DOI or PMC links to read the original sources and their access terms.
Definition
An outward slant of the thigh in which the knees are wide apart and the ankles close together. Genu varum can develop due to skeletal and joint dysplasia (e.g., osteoarthritis; Blount's disease); and malnutrition (e.g., rickets; fluoride poisoning).
Definition: NLM Medical Subject Headings (MeSH) scope note (Public domain (U.S. National Library of Medicine); attribution requested). View the MeSH record.
Also known as: Bow Leg; Bow Legs; Leg, Bow; Legs, Bow; Genu Varus.
Where it fits in the MeSH classification
- Broader topics
- Bone Diseases
- See also
- Rickets
Related concepts
- Osteoarthritis
- Rickets
- Fluoride Poisoning
Research landscape
PubMed indexes 358 records tagged with the MeSH heading “Genu Varum” (counts retrieved 2026-11-04). 123 of them (34.4%) were published from 2020 onward, and the busiest period so far is 2010-2019 with 219 records.
Reviews account for 21 records (5.9%) and meta-analyses for 4. Randomized controlled trials number 16 (4.5%) as a share of all records on the topic.
Show the data
| Period | Records |
|---|---|
| through 1999 | 10 |
| 2000-2009 | 6 |
| 2010-2019 | 219 |
| 2020 onward | 123 |
Publication-type chart data
| Type | Records | Share |
|---|---|---|
| Reviews | 21 | 5.9% |
| Meta-analyses | 4 | 1.1% |
| Randomized controlled trials | 16 | 4.5% |
Method: PubMed query "Genu Varum"[MeSH Terms] with publication-type and date filters, retrieved 2026-11-04.
Reading the evidence in bones, joints, muscles and skin
Joint, bone, muscle and skin conditions are often judged by pain scores, function questionnaires, imaging or photographs, and symptoms can fluctuate, so placebo response and natural improvement matter. Imaging changes are common in people without symptoms. Nothing on this page is advice about treatment. Check how outcomes were measured, whether the comparison group received a placebo or usual care, and how long the benefit lasted.
Evidence from open-access studies
These open-access studies come from PubMed’s best-match results for this heading (papers whose main topic it is), ranked here by citation count, with one recent addition. Each abstract is reproduced in full under its recorded open licence so that you can read the authors’ own words. They illustrate the literature; they are not a systematic summary of it. Citation counts measure attention, not reliability or clinical benefit.
| Study / authors | Year | Source label / design | Europe PMC citations | Licence / source |
|---|---|---|---|---|
| Varus morphology and its surgical implication in osteoarthritic knee and total knee arthroplasty | 2022 | Research article Design not recorded in structured metadata | 17 | cc by PMID 35659012 · DOI · PMC9166439 |
| A comparison of running kinetics in children with and without genu varus: A cross sectional study | 2017 | Research article Design not recorded in structured metadata | 17 | cc by PMID 28926635 · DOI · PMC5605008 |
| Osteotomies around the knee lead to corresponding frontal realignment of the ankle | 2022 | Research article Design not recorded in structured metadata | 12 | cc by PMID 34086135 · DOI · PMC9001540 |
| Impact of sports participation on genu varum among youth: a systematic review | 2026 | Systematic review Design not recorded in structured metadata | 0 | cc by PMID 42830708 · DOI · PMC13662607 |
Varus morphology and its surgical implication in osteoarthritic knee and total knee arthroplasty [1]
Abstract reading summary — source excerpts
- Opening excerpt
- BackgroundKnee varus alignment represents a notorious cause of knee osteoarthritis.
- Closing excerpt
- As a surgical consequence, during performing total knee arthroplasty, the majority of the correction should therefore be made on tibial cut.
- Interpretation limits
- Verbatim excerpts from the authors’ abstract; the closing excerpt may describe a finding, limitation or recommendation. Design, population, effect size and uncertainty have not been independently extracted or appraised. Read the complete abstract and linked paper before interpreting the findings.
Read complete abstract (249 words)
BackgroundKnee varus alignment represents a notorious cause of knee osteoarthritis. It can be caused by tibial deformity, combined tibial-femoral deformity and/or ligament imbalance. Understanding malalignment is crucial in total knee arthroplasty to restore frontal plane neutral mechanical axis. The aim of this study was to determine which factor contributes the most to varus osteoarthritic knee and its related surgical implications in performing a total knee arthroplasty.MethodsWe retrospectively evaluated 140 patients operated for total knee arthroplasty due to a varus knee. Full-leg hip to ankle preoperative X-rays were taken. Radiological parameters recorded were: mechanical axis deviation, hip-knee-ankle, anatomical-mechanical angle, medial neck shaft angle, mechanical lateral distal femoral angle (mLDFA), medial proximal tibial angle (MPTA), joint line convergence angle (JLCA), lateral proximal femoral angle, lateral distal tibial angle (LDTA), femoral bowing, and length of tibia and femur. We also determined ideals tibial and femoral cuts in mm according to mechanical alignment technique. A R2 was calculated based on the linear regression between the predicted values and the observed data.ResultsThe greatest contributor to arthritic varus (R = 0.444) was MPTA. Minor contributors were mLDFA (R = 0.076), JLCA (R = 0.1554), LDTA (R = 0.065), and femoral bowing (R = 0.049). We recorded an average of 7.6 mm in lateral tibial cut thickness to restore neutral alignment.ConclusionsThe radiological major contributor to osteoarthritic varus knee alignment is related to proximal tibia deformity. As a surgical consequence, during performing total knee arthroplasty, the majority of the correction should therefore be made on tibial cut.
Abstract reproduced from the open-access article under the recorded cc by licence; © the authors. PMID 35659012 · DOI · PMC9166439
A comparison of running kinetics in children with and without genu varus: A cross sectional study [2]
Abstract reading summary — source excerpts
- Opening excerpt
- IntroductionVarus knee alignment has been identified as a risk factor for the progression of medial knee osteoarthritis.
- Closing excerpt
- Therefore, practitioners and therapists are advised to conduct balance and strength training programs to improve lower limb alignment and mediolateral control during dynamic movements.
- Interpretation limits
- Verbatim excerpts from the authors’ abstract; the closing excerpt may describe a finding, limitation or recommendation. Design, population, effect size and uncertainty have not been independently extracted or appraised. Read the complete abstract and linked paper before interpreting the findings.
Read complete abstract (232 words)
IntroductionVarus knee alignment has been identified as a risk factor for the progression of medial knee osteoarthritis. However, the underlying mechanisms have not been elucidated yet in children. Thus, the aims of the present study were to examine differences in ground reaction forces, loading rate, impulses, and free moment values during running in children with and without genu varus.MethodsThirty-six boys aged 9-14 volunteered to participate in this study. They were divided in two age-matched groups (genu varus versus healthy controls). Body weight adjusted three dimensional kinetic data (Fx, Fy, Fz) were collected during running at preferred speed using two Kistler force plates for the dominant and non-dominant limb.ResultsIndividuals with knee genu varus produced significantly higher (p = .01; d = 1.09; 95%) body weight adjusted ground reaction forces in the lateral direction (Fx) of the dominant limb compared to controls. On the non-dominant limb, genu varus patients showed significantly higher body weight adjusted ground reaction forces values in the lateral (p = .01; d = 1.08; 86%) and medial (p .05).DiscussionHigher mediolateral ground reaction forces and vertical loading rate amplitudes in boys with genu varus during running at preferred running speed may accelerate the development of progressive joint degeneration in terms of the age at knee osteoarthritis onset. Therefore, practitioners and therapists are advised to conduct balance and strength training programs to improve lower limb alignment and mediolateral control during dynamic movements.
Abstract reproduced from the open-access article under the recorded cc by licence; © the authors. PMID 28926635 · DOI · PMC5605008
Osteotomies around the knee lead to corresponding frontal realignment of the ankle [3]
Abstract reading summary — source excerpts
- Opening excerpt
- IntroductionDespite the fact that osteotomies around the knee represent well-established treatment options for the redistribution of loads and forces within and around the knee joint, unforeseen effects of these osteotomies on the ankle are still to be better understood.
- Closing excerpt
- When planning an osteotomy around the knee for correction of genu varum or valgum, the ankle should also be appreciated-especially in patients with preexisting deformities, ligament instabilities, or joint degeneration around the ankle.
- Interpretation limits
- Verbatim excerpts from the authors’ abstract; the closing excerpt may describe a finding, limitation or recommendation. Design, population, effect size and uncertainty have not been independently extracted or appraised. Read the complete abstract and linked paper before interpreting the findings.
Read complete abstract (375 words)
IntroductionDespite the fact that osteotomies around the knee represent well-established treatment options for the redistribution of loads and forces within and around the knee joint, unforeseen effects of these osteotomies on the ankle are still to be better understood. It was therefore the aim of this study to determine the influence of osteotomies around the knee on the coronal alignment of the ankle. We hypothesize that osteotomies around the knee for correction of genu varum or valgum lead to a change of the ankle orientation in the frontal plane by valgisation or varisation.Materials and methodsLong-leg standing radiographs of 154 consecutive patients undergoing valgisation or varisation osteotomy around the knee in 2017 were obtained and utilized for the purpose of this study. Postoperative radiographs were obtained after union at the osteotomy site. The hip knee ankle angle (HKA), the mechanical lateral distal femur angle (mLDFA), the mechanical medial proximal tibia angle (mMPTA) and five angles around the ankle were measured. Comparison between means was performed using the Wilcoxon-Mann-Whitney test.ResultsOne hundred fifty-four patients (96 males, 58 females) underwent osteotomies around the knee for coronal realignment. The mean age was 51 ± 11 years. Correction osteotomies consisted of 73 HTO, 54 DFOs, and 27 double level osteotomies. Of all osteotomies, 118 were for valgisation and 36 for varisation. For valgisation osteotomies, the mean HKA changed from 5.8° ± 2.9° preoperatively to - 0.9° ± 2.5° postoperatively, whereas the mMPTA changed from 85.9° ± 2.7° to 90.7° ± 3.1° and the malleolar-horizontal-orientation-angle (MHA) changed from 16.4° ± 4.2° to 10.9° ± 4.2°. For varisation osteotomies, the mean HKA changed from - 4.3° ± 3.7° to 1.1° ± 2.2° postoperatively, whereas the mLDFA changed from 85.7° ± 2.2° to 89.3° ± 2.3° and the MHA changed from 8.8° ± 5.1° to 11.2° ± 3.2°.ConclusionOsteotomies around the knee for correction of coronal limb alignment not only lead to lateralization or medialization of the weight-bearing line at the knee but also lead to a coronal reorientation of the ankle. This can be measured at the ankle using the MHA. When planning an osteotomy around the knee for correction of genu varum or valgum, the ankle should also be appreciated-especially in patients with preexisting deformities, ligament instabilities, or joint degeneration around the ankle.
Abstract reproduced from the open-access article under the recorded cc by licence; © the authors. PMID 34086135 · DOI · PMC9001540
Impact of sports participation on genu varum among youth: a systematic review [4]
Abstract reading summary — source excerpts
- Opening excerpt
- IntroductionGenu varum occurs more frequently among young male athletes involved in high levels of physical activity, particularly adolescent male soccer players when compared to the general population.
- Closing excerpt
- Furthermore, the relationship between genu varum and non-soccer sports should be investigated so the movement and loading characteristics specific to different sports need to be evaluated.
- Interpretation limits
- Verbatim excerpts from the authors’ abstract; the closing excerpt may describe a finding, limitation or recommendation. Design, population, effect size and uncertainty have not been independently extracted or appraised. Read the complete abstract and linked paper before interpreting the findings.
Read complete abstract (242 words)
IntroductionGenu varum occurs more frequently among young male athletes involved in high levels of physical activity, particularly adolescent male soccer players when compared to the general population. This study provides a contemporary examination of the relationship between genu varum and participation in youth sport.Sources of dataA systematic review was performed following Preferred Reporting Items for Systematic Reviews and Meta-Analysis guidelines. The literature search was conducted in Web of Science, Scopus, PubMed, Embase, and CINAHL databases.Areas of agreementGenu varum is more prevalent among athletes than among age-matched non-athlete controls and has been reported more often in male soccer players, with overloading of the proximal medial tibial growth plate proposed as a possible contributing mechanism.Areas of controversyIntercondylar-intermalleolar distance differed in younger age groups with some reporting negative values and some reporting positive values.Growing pointsIn recent years, there has been a marked improvement in the methods used to assess lower limb malalignment in young athletes. Clinical measures are simple but lack detail; whole-leg radiographs are increasingly used to capture these details.Areas timely for developing researchThe lack of longitudinal data examining changes in lower extremity alignment with sports loading during the growth period is an important deficiency of the current research. Long-term follow-up studies are needed to clarify the nature and incidence of genu varum in young athletes, including females. Furthermore, the relationship between genu varum and non-soccer sports should be investigated so the movement and loading characteristics specific to different sports need to be evaluated.
Abstract reproduced from the open-access article under the recorded cc by licence; © the authors. PMID 42830708 · DOI · PMC13662607
Key reviews and meta-analyses
The most cited review-type papers among PubMed’s best-match results for this heading, listed with bibliographic details only. Follow the links for the full text and access terms.
- Research article Biomechanics of high tibial osteotomy [5]
- Research article High tibial osteotomy: evolution of research and clinical applications--a Canadian experience [6]
- Research article Total knee arthroplasty in the varus knee: tips and tricks [7]
- Research article Comparison of navigated and conventional high tibial osteotomy for the treatment of osteoarthritic knees with varus deformity: A meta-analysis [8]
- Research article Bowlegs and Intensive Football Training in Children and Adolescents [9]
- Research article Frontal plane knee moment in clinical gait analysis: A systematic review on the effect of kinematic gait changes [10]
References
- Suardi C, Stimolo D, Zanna L, Carulli C, Fabrizio M, Civinini R, et al.. Varus morphology and its surgical implication in osteoarthritic knee and total knee arthroplasty. . 2022. PMID 35659012 · DOI · PMC9166439
- Jafarnezhadgero AA, Shad MM, Majlesi M, Granacher U. A comparison of running kinetics in children with and without genu varus: A cross sectional study. . 2017. PMID 28926635 · DOI · PMC5605008
- Konrads C, Eis A, Ahmad SS, Stöckle U, Döbele S. Osteotomies around the knee lead to corresponding frontal realignment of the ankle. . 2022. PMID 34086135 · DOI · PMC9001540
- Işın A, Akdağ E, Demirkıran B, Caine D. Impact of sports participation on genu varum among youth: a systematic review. . 2026. PMID 42830708 · DOI · PMC13662607
- Amis AA. Biomechanics of high tibial osteotomy. Knee Surg Sports Traumatol Arthrosc. 2013. PMID 22773067 · DOI
- McNamara I, Birmingham TB, Fowler PJ, Giffin JR. High tibial osteotomy: evolution of research and clinical applications--a Canadian experience. Knee Surg Sports Traumatol Arthrosc. 2013. PMID 23052112 · DOI
- Rossi R, Cottino U, Bruzzone M, Dettoni F, Bonasia DE, Rosso F. Total knee arthroplasty in the varus knee: tips and tricks. Int Orthop. 2019. PMID 30141140 · DOI
- Wu ZP, Zhang P, Bai JZ, Liang Y, Chen PT, He JS, et al.. Comparison of navigated and conventional high tibial osteotomy for the treatment of osteoarthritic knees with varus deformity: A meta-analysis. Int J Surg. 2018. PMID 29555521 · DOI
- Thaller PH, Fürmetz J, Chen F, Degen N, Manz KM, Wolf F. Bowlegs and Intensive Football Training in Children and Adolescents. Dtsch Arztebl Int. 2018. PMID 29968558 · DOI · PMC6050431
- Byrnes SK, Holder J, Stief F, Wearing S, Böhm H, Dussa CU, et al.. Frontal plane knee moment in clinical gait analysis: A systematic review on the effect of kinematic gait changes. Gait Posture. 2022. PMID 36049417 · DOI
About this article
- Sources
- NLM Medical Subject Headings (definition, synonyms); NCBI PubMed (counts, identifiers); Europe PMC (open-access abstracts and citation counts).
- Verification
- Every reference was resolved against PubMed on 2026-11-04; title, year and DOI matched.
- Review state
- automated source verified; no human expert review has been recorded yet.
- Version
- 1, last updated 2026-11-04.
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Evidence strength
EvidenceHelix's computed view of the study designs behind this topic: how common meta-analyses, randomized trials and reviews are, how recent the literature is, and a plain-language reading. It describes the design mix of the literature. It is not a quality appraisal of any study, and it is not medical advice.