EvidenceLib · Topic area
Digestive System and Liver
Diseases of the gut, liver, pancreas and gallbladder, from reflux and bowel disease to hepatitis and cirrhosis. 66 evidence-grounded articles and 25 open-access full-text articles.
Acute-On-Chronic Liver Failure
Sudden liver failure in the presence of underlying compensated chronic liver disease (e.g., liver cirrhosis; hepatitis; and liver injury and failure) due to a precipitating acute hepatic insult.
Bile Reflux
Retrograde bile flow.
Biliary Dyskinesia
A motility disorder characterized by biliary colic, absence of gallstones, and an abnormal gallbladder ejection fraction.
Biliary Fistula
Abnormal passage in any organ of the biliary tract or between biliary organs and other organs.
Biliary Tract Diseases
Diseases in any part of the biliary tract including the bile ducts and the gallbladder.
Celiac Disease
A malabsorption syndrome that is precipitated by the ingestion of foods containing gluten, such as wheat, rye, and barley.
Cholecystitis
Inflammation of the gallbladder; generally caused by impairment of BILE flow, gallstones in the biliary tract, infections, or other diseases.
Cholelithiasis
Presence or formation of gallstones in the biliary tract, usually in the gallbladder (cholecystolithiasis) or the common bile duct (choledocholithiasis).
Cholestasis
Impairment of bile flow due to obstruction in small bile ducts (intrahepatic cholestasis) or obstruction in large bile ducts (extrahepatic cholestasis).
Chronic Hepatitis
Inflammation of the liver with ongoing hepatocellular injury for 6 months or more, characterized by necrosis of hepatocytes and inflammatory cell (leukocytes) infiltration.
Colitis
Inflammation of the colon section of the large intestine (intestine, large), usually with symptoms such as diarrhea (often with blood and mucus), abdominal pain, and fever.
Colonic Pseudo-Obstruction
Functional obstruction of the colon leading to megacolon in the absence of obvious colonic diseases or mechanical obstruction.
Congenital Hyperinsulinism
A familial, nontransient hypoglycemia with defects in negative feedback of glucose-regulated insulin release.
Crohn Disease
A chronic transmural inflammation that may involve any part of the digestive tract from mouth to ANUS, mostly found in the ileum, the cecum, and the colon.
Digestive System Diseases
Diseases in any part of the gastrointestinal tract or the accessory organs (liver; biliary tract; pancreas).
Diverticulum
A pouch or sac developed from a tubular or saccular organ, such as the gastrointestinal tract.
Duodenal Obstruction
Hindrance of the passage of luminal contents in the duodenum.
Duodenitis
Inflammation of the duodenum section of the small intestine (intestine, small).
Dysentery
Acute inflammation of the intestine associated with infectious diarrhea of various etiologies, generally acquired by eating contaminated food containing toxins, biological derived from bacteria or other microorganisms.
End Stage Liver Disease
Final stage of a liver disease when the liver failure is irreversible and liver transplantation is needed.
Enterocolitis
Inflammation of the mucosa of both the small intestine and the large intestine.
Eosinophilic Esophagitis
Chronic esophagitis characterized by esophageal mucosal eosinophilia.
Esophageal Achalasia
A motility disorder of the esophagus in which the lower esophageal sphincter (near the cardia) fails to relax resulting in functional obstruction of the esophagus, and dysphagia.
Esophageal Fistula
Abnormal passage communicating with the esophagus.
Esophageal Motility Disorders
Disorders affecting the motor function of the upper esophageal sphincter; lower esophageal sphincter; the esophagus body, or a combination of these parts.
Esophageal Perforation
An opening or hole in the esophagus that is caused by trauma, injury, or pathological process.
Exocrine Pancreatic Insufficiency
A malabsorption condition resulting from greater than 10% reduction in the secretion of pancreatic digestive enzymes (lipase; proteases; and amylase) by the exocrine pancreas into the duodenum.
Fatty Liver
Lipid infiltration of the hepatic parenchymal cells resulting in a yellow-colored liver.
Fecal Incontinence
Failure of voluntary control of the anal sphincters, with involuntary passage of feces and flatus.
Focal Nodular Hyperplasia
Solitary or multiple benign hepatic vascular tumors, usually occurring in women of 20-50 years of age.
Gallbladder Diseases
Diseases of the gallbladder.
Gallstones
Solid crystalline precipitates in the biliary tract, usually formed in the gallbladder, resulting in the condition of cholelithiasis.
Gastric Dilatation
Abnormal distention of the stomach due to accumulation of gastric contents that may reach 10 to 15 liters.
Gastric Outlet Obstruction
The hindering of output from the stomach into the small intestine.
Gastroenteritis
Inflammation of any segment of the gastrointestinal tract from esophagus to rectum.
Gastroesophageal Reflux
Retrograde flow of gastric juice (gastric acid) and/or duodenal contents (bile acids; pancreatic juice) into the distal esophagus, commonly due to incompetence of the lower esophageal sphincter.
Gastroparesis
Chronic delayed gastric emptying.
Hematemesis
Vomiting of blood that is either fresh bright red, or older coffee-ground in character.
Hepatorenal Syndrome
Functional kidney failure in patients with liver disease, usually liver cirrhosis or portal hypertension (hypertension, portal), and in the absence of intrinsic renal disease or kidney abnormality.
Ileus
A condition caused by the lack of intestinal peristalsis or intestinal motility without any mechanical obstruction.
Inflammatory Bowel Diseases
Chronic, non-specific inflammation of the gastrointestinal tract.
Intestinal Fistula
An abnormal anatomical passage between the intestine, and another segment of the intestine or other organs.
Intestinal Obstruction
Any impairment, arrest, or reversal of the normal flow of intestinal contents toward the anal canal.
Intestinal Pseudo-Obstruction
A type of ileus, a functional not mechanical obstruction of the intestines.
Intussusception
A form of intestinal obstruction caused by the prolapse of a part of the intestine into the adjoining intestinal lumen.
Irritable Bowel Syndrome
A disorder with chronic or recurrent colonic symptoms without a clearcut etiology.
Liver Cirrhosis
Liver disease in which the normal microcirculation, the gross vascular anatomy, and the hepatic architecture have been variably destroyed and altered with fibrous septa surrounding regenerated or regenerating parenchymal nodules.
Liver Failure
Severe inability of the liver to perform its normal metabolic functions, as evidenced by severe jaundice and abnormal serum levels of ammonia; bilirubin; alkaline phosphatase; aspartate aminotransferase; lactate dehydrogenases; an
Malabsorption Syndromes
General term for a group of malnutrition syndromes caused by failure of normal intestinal absorption of nutrients.
Mallory-Weiss Syndrome
A condition characterized by mucosal tears at the esophagogastric junction, sometimes with hematemesis.
Megacolon
Dilatation of the colon, often to alarming dimensions.
Mucositis
An inflammation of the mucosa with burning or tingling sensation.
Pancreatitis
Inflammation of the pancreas.
Peptic Ulcer
Ulcer that occurs in the regions of the gastrointestinal tract which come into contact with gastric juice containing pepsin and gastric acid.
Peritoneal Fibrosis
Disorder characterized by a wide range of structural changes in peritoneum, resulting from fibrogenic or inflammatory processes.
Pneumatosis Cystoides Intestinalis
A condition characterized by the presence of multiple gas-filled cysts in the intestinal wall, the submucosa and/or subserosa of the intestine.
Pneumoperitoneum
A condition with trapped gas or air in the peritoneal cavity, usually secondary to perforation of the internal organs such as the LUNG and the gastrointestinal tract, or to recent surgery.
Pouchitis
Acute inflammation in the intestinal mucosa of the continent ileal reservoir (or pouch) in patients who have undergone ileostomy and restorative proctocolectomy (proctocolectomy, restorative).
Proctitis
Inflammation of the mucous membrane of the rectum, the distal end of the large intestine (intestine, large).
Pyloric Stenosis
Narrowing of the pyloric canal with varied etiology.
Rectal Prolapse
Protrusion of the rectal mucous membrane through the anus.
Short Bowel Syndrome
A malabsorption syndrome resulting from extensive operative resection of the small intestine, the absorptive region of the gastrointestinal tract.
Shwachman-Diamond Syndrome
An inherited syndrome characterized by exocrine pancreatic insufficiency; hematologic abnormalities (e.g., bone marrow hypoplasia), and skeletal abnormalities (e.g., metaphyseal chondroplasia).
Steatorrhea
A condition that is characterized by chronic fatty diarrhea, a result of abnormal digestion and/or intestinal absorption of FATS.
Stomach Ulcer
Ulceration of the gastric mucosa due to contact with gastric juice.
Superior Mesenteric Artery Syndrome
Duodenal obstruction by the superior mesenteric artery (mesenteric artery, superior) which travels in the root of the mesentery and crosses over the duodenum.
Open-access full-text articles
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Fat-Soluble Vitamins A, D, E, and K: Review of the Literature and Points of Interest for the Clinician
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Transcutaneous vagus nerve stimulation: a bibliometric study on current research hotspots and status
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Microplastics in the Human Body: Exposure, Detection, and Risk of Carcinogenesis: A State-of-the-Art Review
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Patient‐derived xenograft model in cancer: establishment and applications
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Evaluating the Bidirectional Causal Effects of Alzheimer’s Disease Across Multiple Conditions: A Systematic Review and Meta-Analysis of Mendelian Randomization Studies
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Research progress on the mechanisms of comorbidity between functional gastrointestinal disorders and mental disorders: A review
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All-cause and cause-specific mortality in psoriasis patients: a systematic review and meta-analysis
Yi Yang, Qin Zhang, Anning Huang et al. · Frontiers in Immunology 2025 · CC BY 4.0
Pathologic and Therapeutic Schwann Cells
Michael R Shurin, Sarah E Wheeler, Hua Zhong et al. · Cells 2025 · CC BY 4.0
Comprehensive Insights into Tracheoesophageal Fistula Pathophysiology, Diagnosis, Treatment, and Future Directions
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Variations in multimorbidity measurement in studies evaluating hospitalisation in older adults: a systematic review
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Liver Fibrosis and Risk of Incident Dementia in the General Population: Systematic Review With Meta‐Analysis
Mohamad Jamalinia, Fatemeh Zare, Amedeo Lonardo · Health Science Reports 2025 · CC BY 4.0
Recent advances in natural polysaccharides for type 2 diabetes management: sources, structural characteristics, and mechanistic insights
Zexiang Liu, Hanlong Wang, Xiujuan Gong et al. · Frontiers in Pharmacology 2025 · CC BY 4.0
Vonoprazan-amoxicillin dual therapy vs. proton pump inhibitor based dual therapy for Helicobacter pylori eradication: a meta-analysis
You Lv, Hong-Hua Zhou, Jia-Geng Sun et al. · Frontiers in Medicine 2025 · CC BY 4.0
Mendelian randomization studies on the causal relationship between insomnia and disease
Xuan Hou, Yingjun Wei, Yongfeng Wang et al. · Frontiers in Medicine 2025 · CC BY 4.0
Promoting and inhibiting factors for the implementation of evidence-based non-invasive treatment programs for patients with knee- and/or hip-osteoarthritis: a rapid review
Jennifer Bosompem, Peter Rasche, Nino Chikhradze et al. · BMC Health Services Research 2026 · CC BY 4.0
Ethnopharmacology, phytochemistry, and pharmacology of sea buckthorn (Hippophae rhamnoides L.): a comprehensive review
Mingqi Liu, Tiantian Yu, Ulipan Nurlan et al. · Frontiers in Pharmacology 2026 · CC BY 4.0
Recent Developments and Applicability of In Vitro Gut Microbiota Models in Biomedical Research and Digestive Diseases—A Systematic Review
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Tong Li, Xueying Zhao · Molecules 2026 · CC BY 4.0
Human biomarker navigator
Meng‐Yao Li, Qian Zhang, Zijie Wang et al. · iMeta 2026 · CC BY 4.0
Association between tea consumption and gastroesophageal reflux disease
Hongying Cao, Xiaoyi Huang, Xiaosong Zhi et al. · Medicine 2019 · CC BY 4.0
A Systematic Review of What Barriers and Facilitators Prevent and Enable Physical Healthcare Services Access for Autistic Adults
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Clinical acupuncture therapy for chronic cholecystitis
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