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Guilt

Psychiatry and Psychology · NLM MeSH · updated 2026-11-04 · version 1

Citations verified against PubMedNot yet clinician-reviewed10 referencesApproximately 4 min read

Subjective feeling of having committed an error, offense or sin; unpleasant feeling of self-criticism.

Table of Contents

1. Definition2. Research landscape3. Reading the evidence4. Open-access studies5. Key reviews6. References7. About this article

Definition and research guide

This page combines a MeSH definition, publication statistics and selected research abstracts. It is a starting point for reading the literature, not a medical textbook or a systematic evidence review.

Content available: 4 complete abstracts (728 words), 10 references. Full article text is not stored or reproduced here; follow the PMID, DOI or PMC links to read the original sources and their access terms.

Definition

Subjective feeling of having committed an error, offense or sin; unpleasant feeling of self-criticism. These result from acts, impulses, or thoughts contrary to one's personal conscience.

Definition: NLM Medical Subject Headings (MeSH) scope note (Public domain (U.S. National Library of Medicine); attribution requested). View the MeSH record.

Also known as: Guilts.

Where it fits in the MeSH classification

Broader topics
Emotions
Narrower topics
Shame

Research landscape

PubMed indexes 8,136 records tagged with the MeSH heading “Guilt” (counts retrieved 2026-10-31). 1,774 of them (21.8%) were published from 2020 onward, and the busiest period so far is through 1999 with 2,714 records.

Reviews account for 564 records (6.9%) and meta-analyses for 50. Randomized controlled trials number 216 (2.7%) as a share of all records on the topic.

PubMed records by publication periodthrough 1999: 2,714 records; 2000-2009: 1,444 records; 2010-2019: 2,204 records; 2020 onward: 1,774 records2,714through 19991,4442000-20092,2042010-20191,7742020 onward
Records in PubMed indexed with this heading, by publication period. Real counts from NCBI E-utilities; the final period covers only part of the current year. Volume reflects how much has been published, not how strong the evidence is.
Show the data
PeriodRecords
through 19992,714
2000-20091,444
2010-20192,204
2020 onward1,774
Share of records by publication typeReviews: 6.9 percent; Meta-analyses: 0.6 percent; Randomized controlled trials: 2.7 percentReviews6.9% (564)Meta-analyses0.6% (50)Randomized controlled trials2.7% (216)
Share of all PubMed records on this heading that carry each publication type. Types overlap with other records, so the shares do not sum to 100%.
Publication-type chart data
Publication types among 8,136 PubMed records
TypeRecordsShare
Reviews5646.9%
Meta-analyses500.6%
Randomized controlled trials2162.7%

Method: PubMed query "Guilt"[MeSH Terms] with publication-type and date filters, retrieved 2026-10-31.

Reading the evidence in psychiatry and psychology

Research on mental health and behaviour relies on questionnaires, interviews and rating scales rather than physical measurements, so how a condition was defined and measured shapes every result. Many studies are observational or small, placebo responses can be large, and findings in one group or culture may not carry over to another. Nothing on this page is advice about diagnosis or treatment; anyone worried about their mental health should talk to a qualified clinician. Check how outcomes were measured, who took part and how long they were followed.

Evidence from open-access studies

These open-access studies come from PubMed’s best-match results for this heading (papers whose main topic it is), ranked here by citation count, with one recent addition. Each abstract is reproduced in full under its recorded open licence so that you can read the authors’ own words. They illustrate the literature; they are not a systematic summary of it. Citation counts measure attention, not reliability or clinical benefit.

Study comparison — selected abstracts, not a systematic review
Study / authorsYearSource label / designEurope PMC citationsLicence / source
Stigma and Self-Stigma in Addiction
Matthews S, Dwyer R, Snoek A
2017Research article
Design not recorded in structured metadata
109cc by
PMID 28470503 · DOI · PMC5527047
HIV, violence, blame and shame: pathways of risk to internalized HIV stigma among South African adolescents living with HIV
Pantelic M, Boyes M, Cluver L, Meinck F
2017Research article
Design not recorded in structured metadata
86cc by
PMID 28853517 · DOI · PMC5577824
Needs and fears of young people presenting at accident and emergency department following an act of self-harm: secondary analysis of qualitative data
Owens C, Hansford L, Sharkey S, Ford T
2016Research article
Design not recorded in structured metadata
73cc by
PMID 26450583 · DOI · PMC4807637
Online Sexual Harassment, Disordered Eating Attitudes, and Body Shame in Young Women
Milson R, Ashton-Rowling E, Cole V, Graham B, Nicoll A
2026Research article
Design not recorded in structured metadata
1cc by
PMID 40304699 · DOI · PMC13031364

Stigma and Self-Stigma in Addiction [1]

Research article Matthews S, Dwyer R, Snoek A · · 2017 · cited 109 times (Europe PMC)

Abstract reading summary — source excerpts
Opening excerpt
Addictions are commonly accompanied by a sense of shame or self-stigmatization.
Closing excerpt
Our thesis is partly theoretical, partly empirical, as we source our claims about the process of internalization from interviews with people in treatment for substance use problems.
Interpretation limits
Verbatim excerpts from the authors’ abstract; the closing excerpt may describe a finding, limitation or recommendation. Design, population, effect size and uncertainty have not been independently extracted or appraised. Read the complete abstract and linked paper before interpreting the findings.
Read complete abstract (132 words)

Addictions are commonly accompanied by a sense of shame or self-stigmatization. Self-stigmatization results from public stigmatization in a process leading to the internalization of the social opprobrium attaching to the negative stereotypes associated with addiction. We offer an account of how this process works in terms of a range of looping effects, and this leads to our main claim that for a significant range of cases public stigma figures in the social construction of addiction. This rests on a social constructivist account in which those affected by public stigmatization internalize its norms. Stigma figures as part-constituent of the dynamic process in which addiction is formed. Our thesis is partly theoretical, partly empirical, as we source our claims about the process of internalization from interviews with people in treatment for substance use problems.

Abstract reproduced from the open-access article under the recorded cc by licence; © the authors. PMID 28470503 · DOI · PMC5527047

HIV, violence, blame and shame: pathways of risk to internalized HIV stigma among South African adolescents living with HIV [2]

Research article Pantelic M, Boyes M, Cluver L, Meinck F · · 2017 · cited 86 times (Europe PMC)

Abstract reading summary — source excerpts
Opening excerpt
IntroductionInternalized HIV stigma is a key risk factor for negative outcomes amongst adolescents living with HIV (ALHIV), including non-adherence to anti-retroviral treatment, loss-to-follow-up and morbidity.
Closing excerpt
This highlights the potential for interventions that do not explicitly target adolescents living with HIV but are sensitive to their needs.
Interpretation limits
Verbatim excerpts from the authors’ abstract; the closing excerpt may describe a finding, limitation or recommendation. Design, population, effect size and uncertainty have not been independently extracted or appraised. Read the complete abstract and linked paper before interpreting the findings.
Read complete abstract (299 words)

IntroductionInternalized HIV stigma is a key risk factor for negative outcomes amongst adolescents living with HIV (ALHIV), including non-adherence to anti-retroviral treatment, loss-to-follow-up and morbidity. This study tested a theoretical model of multi-level risk pathways to internalized HIV stigma among South African ALHIV.MethodsFrom 2013 to 2015, a survey using total population sampling of ALHIV who had ever initiated anti-retroviral treatment (ART) in 53 public health facilities in the Eastern Cape, South Africa was conducted. Community-tracing ensured inclusion of ALHIV who were defaulting from ART or lost to follow-up. 90.1% of eligible ALHIV were interviewed (n = 1060, 55% female, mean age = 13.8, 21% living in rural locations). HIV stigma mechanisms (internalized, enacted, and anticipated), HIV-related disability, violence victimization (physical, emotional, sexual abuse, bullying victimization) were assessed using well-validated self-report measures. Structural equation modelling was used to test a theoretically informed model of risk pathways from HIV-related disability to internalized HIV stigma. The model controlled for age, gender and urban/rural address.ResultsPrevalence of internalized HIV stigma was 26.5%. As hypothesized, significant associations between internalized stigma and anticipated stigma, as well as depression were obtained. Unexpectedly, HIV-related disability, victimization, and enacted stigma were not directly associated with internalized stigma. Instead significant pathways were identified via anticipated HIV stigma and depression. The model fitted the data well (RMSEA = .023; CFI = .94; TLI = .95; WRMR = 1.070).ConclusionsThese findings highlight the complicated nature of internalized HIV stigma. Whilst it is seemingly a psychological process, indirect pathways suggest multi-level mechanisms leading to internalized HIV stigma. Findings suggest that protection from violence within homes, communities and schools may interrupt risk pathways from HIV-related health problems to psychological distress and internalized HIV stigma. This highlights the potential for interventions that do not explicitly target adolescents living with HIV but are sensitive to their needs.

Abstract reproduced from the open-access article under the recorded cc by licence; © the authors. PMID 28853517 · DOI · PMC5577824

Needs and fears of young people presenting at accident and emergency department following an act of self-harm: secondary analysis of qualitative data [3]

Research article Owens C, Hansford L, Sharkey S, Ford T · · 2016 · cited 73 times (Europe PMC)

Abstract reading summary — source excerpts
Opening excerpt
BackgroundPresentation at an accident and emergency (A&E) department is a key opportunity to engage with a young person who self-harms.
Closing excerpt
Further hypothesis testing and trials of different models of care delivery for this vulnerable group are warranted.
Interpretation limits
Verbatim excerpts from the authors’ abstract; the closing excerpt may describe a finding, limitation or recommendation. Design, population, effect size and uncertainty have not been independently extracted or appraised. Read the complete abstract and linked paper before interpreting the findings.
Read complete abstract (198 words)

BackgroundPresentation at an accident and emergency (A&E) department is a key opportunity to engage with a young person who self-harms. The needs of this vulnerable group and their fears about presenting to healthcare services, including A&E, are poorly understood.AimsTo examine young people's perceptions of A&E treatment following self-harm and their views on what constitutes a positive clinical encounter.MethodSecondary analysis of qualitative data from an experimental online discussion forum. Threads selected for secondary analysis represent the views of 31 young people aged 16-25 with experience of self-harm.ResultsParticipants reported avoiding A&E whenever possible, based on their own and others' previous poor experiences. When forced to seek emergency care, they did so with feelings of shame and unworthiness. These feelings were reinforced when they received what they perceived as punitive treatment from A&E staff, perpetuating a cycle of shame, avoidance and further self-harm. Positive encounters were those in which they received 'treatment as usual', i.e. non-discriminatory care, delivered with kindness, which had the potential to challenge negative self-evaluation and break the cycle.ConclusionsThe clinical needs of young people who self-harm continue to demand urgent attention. Further hypothesis testing and trials of different models of care delivery for this vulnerable group are warranted.

Abstract reproduced from the open-access article under the recorded cc by licence; © the authors. PMID 26450583 · DOI · PMC4807637

Online Sexual Harassment, Disordered Eating Attitudes, and Body Shame in Young Women [4]

Research article Milson R, Ashton-Rowling E, Cole V, Graham B, Nicoll A · · 2026 · cited 1 times (Europe PMC)

Abstract reading summary — source excerpts
Opening excerpt
Sexual harassment is associated with disordered eating in young women, directly and indirectly, via body shame.
Closing excerpt
These findings offer initial support for examining the utility of online sexual harassment and body shame to further understand disordered eating in young women.
Interpretation limits
Verbatim excerpts from the authors’ abstract; the closing excerpt may describe a finding, limitation or recommendation. Design, population, effect size and uncertainty have not been independently extracted or appraised. Read the complete abstract and linked paper before interpreting the findings.
Read complete abstract (99 words)

Sexual harassment is associated with disordered eating in young women, directly and indirectly, via body shame. However, today, young women are not only experiencing sexual harassment in-person, but also online. We recruited a non-clinical sample of young women (N = 146) to examine the direct and indirect relationships between online sexual harassment, disordered eating attitudes, and body shame. Findings revealed that online sexual harassment positively predicted disordered eating attitudes directly and indirectly, via body shame. These findings offer initial support for examining the utility of online sexual harassment and body shame to further understand disordered eating in young women.

Abstract reproduced from the open-access article under the recorded cc by licence; © the authors. PMID 40304699 · DOI · PMC13031364

Key reviews and meta-analyses

The most cited review-type papers among PubMed’s best-match results for this heading, listed with bibliographic details only. Follow the links for the full text and access terms.

  • Research article Research review: the importance of callous-unemotional traits for developmental models of aggressive and antisocial behavior [5]
    Frick PJ, White SF · J Child Psychol Psychiatry · 2008 · cited 646 times (Europe PMC)
  • Research article Guilt: an interpersonal approach [6]
    Baumeister RF, Stillwell AM, Heatherton TF · Psychol Bull · 1994 · cited 392 times (Europe PMC)
  • Research article Shame, guilt, and depressive symptoms: a meta-analytic review [7]
    Kim S, Thibodeau R, Jorgensen RS · Psychol Bull · 2011 · cited 387 times (Europe PMC)
  • Research article When the social self is threatened: shame, physiology, and health [8]
    Dickerson SS, Gruenewald TL, Kemeny ME · J Pers · 2004 · cited 331 times (Europe PMC)
  • Research article Perceived barriers and facilitators towards help-seeking for eating disorders: A systematic review [9]
    Ali K, Farrer L, Fassnacht DB, Gulliver A, Bauer S, Griffiths KM · Int J Eat Disord · 2017 · cited 272 times (Europe PMC)
  • Research article Stop blaming the victim: a meta-analysis on rape myths [10]
    Suarez E, Gadalla TM · J Interpers Violence · 2010 · cited 252 times (Europe PMC)

References

  1. Matthews S, Dwyer R, Snoek A. Stigma and Self-Stigma in Addiction. . 2017. PMID 28470503 · DOI · PMC5527047
  2. Pantelic M, Boyes M, Cluver L, Meinck F. HIV, violence, blame and shame: pathways of risk to internalized HIV stigma among South African adolescents living with HIV. . 2017. PMID 28853517 · DOI · PMC5577824
  3. Owens C, Hansford L, Sharkey S, Ford T. Needs and fears of young people presenting at accident and emergency department following an act of self-harm: secondary analysis of qualitative data. . 2016. PMID 26450583 · DOI · PMC4807637
  4. Milson R, Ashton-Rowling E, Cole V, Graham B, Nicoll A. Online Sexual Harassment, Disordered Eating Attitudes, and Body Shame in Young Women. . 2026. PMID 40304699 · DOI · PMC13031364
  5. Frick PJ, White SF. Research review: the importance of callous-unemotional traits for developmental models of aggressive and antisocial behavior. J Child Psychol Psychiatry. 2008. PMID 18221345 · DOI
  6. Baumeister RF, Stillwell AM, Heatherton TF. Guilt: an interpersonal approach. Psychol Bull. 1994. PMID 8165271 · DOI
  7. Kim S, Thibodeau R, Jorgensen RS. Shame, guilt, and depressive symptoms: a meta-analytic review. Psychol Bull. 2011. PMID 21219057 · DOI
  8. Dickerson SS, Gruenewald TL, Kemeny ME. When the social self is threatened: shame, physiology, and health. J Pers. 2004. PMID 15509281 · DOI
  9. Ali K, Farrer L, Fassnacht DB, Gulliver A, Bauer S, Griffiths KM. Perceived barriers and facilitators towards help-seeking for eating disorders: A systematic review. Int J Eat Disord. 2017. PMID 27526643 · DOI
  10. Suarez E, Gadalla TM. Stop blaming the victim: a meta-analysis on rape myths. J Interpers Violence. 2010. PMID 20065313 · DOI

About this article

Sources
NLM Medical Subject Headings (definition, synonyms); NCBI PubMed (counts, identifiers); Europe PMC (open-access abstracts and citation counts).
Verification
Every reference was resolved against PubMed on 2026-11-04; title, year and DOI matched.
Review state
automated source verified; no human expert review has been recorded yet.
Version
1, last updated 2026-11-04.

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At a glance

8,136
PubMed records on this heading
22%
published since 2020
564
review articles
216
randomized trials
10
verified references below

Counts come from PubMed on 2026-10-31; they show how much has been written, not how strong the evidence is.

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Sources

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