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Inlays

Diagnostics and Medical Technology · NLM MeSH · updated 2026-11-04 · version 1

Citations verified against PubMedNot yet clinician-reviewed10 referencesApproximately 5 min read

Restorations of metal, porcelain, or plastic made to fit a cavity preparation, then cemented into the tooth.

Table of Contents

1. Definition2. Research landscape3. Reading the evidence4. Open-access studies5. Key reviews6. References7. About this article

Definition and research guide

This page combines a MeSH definition, publication statistics and selected research abstracts. It is a starting point for reading the literature, not a medical textbook or a systematic evidence review.

Content available: 4 complete abstracts (1,046 words), 10 references. Full article text is not stored or reproduced here; follow the PMID, DOI or PMC links to read the original sources and their access terms.

Definition

Restorations of metal, porcelain, or plastic made to fit a cavity preparation, then cemented into the tooth. Onlays are restorations which fit into cavity preparations and overlay the occlusal surface of a tooth or teeth. Onlays are retained by frictional or mechanical factors.

Definition: NLM Medical Subject Headings (MeSH) scope note (Public domain (U.S. National Library of Medicine); attribution requested). View the MeSH record.

Also known as: Inlay; Inlay, Dental; Inlays, Dental; Dental Inlays; Onlays; Onlay; Dental Onlay; Onlay, Dental.

Where it fits in the MeSH classification

Broader topics
Dental Restoration, Permanent

Research landscape

PubMed indexes 3,519 records tagged with the MeSH heading “Inlays” (counts retrieved 2026-11-04). 215 of them (6.1%) were published from 2020 onward, and the busiest period so far is through 1999 with 2,269 records.

Reviews account for 188 records (5.3%) and meta-analyses for 12. Randomized controlled trials number 130 (3.7%) as a share of all records on the topic.

PubMed records by publication periodthrough 1999: 2,269 records; 2000-2009: 620 records; 2010-2019: 415 records; 2020 onward: 215 records2,269through 19996202000-20094152010-20192152020 onward
Records in PubMed indexed with this heading, by publication period. Real counts from NCBI E-utilities; the final period covers only part of the current year. Volume reflects how much has been published, not how strong the evidence is.
Show the data
PeriodRecords
through 19992,269
2000-2009620
2010-2019415
2020 onward215
Share of records by publication typeReviews: 5.3 percent; Meta-analyses: 0.3 percent; Randomized controlled trials: 3.7 percentReviews5.3% (188)Meta-analyses0.3% (12)Randomized controlled trials3.7% (130)
Share of all PubMed records on this heading that carry each publication type. Types overlap with other records, so the shares do not sum to 100%.
Publication-type chart data
Publication types among 3,519 PubMed records
TypeRecordsShare
Reviews1885.3%
Meta-analyses120.3%
Randomized controlled trials1303.7%

Method: PubMed query "Inlays"[MeSH Terms] with publication-type and date filters, retrieved 2026-11-04.

Reading the evidence in diagnostics and medical technology

A test or device is judged by how well it detects a condition, how often it gives false alarms or misses cases, and whether using it improves outcomes for people. Accuracy depends on who is tested and how common the condition is, so a test that performs well in a specialist hospital can perform differently in the community. Check the reference standard, the population studied, the sensitivity and specificity and whether results were confirmed in a separate group.

Evidence from open-access studies

These open-access studies come from PubMed’s best-match results for this heading (papers whose main topic it is), ranked here by citation count, with one recent addition. Each abstract is reproduced in full under its recorded open licence so that you can read the authors’ own words. They illustrate the literature; they are not a systematic summary of it. Citation counts measure attention, not reliability or clinical benefit.

Study comparison — selected abstracts, not a systematic review
Study / authorsYearSource label / designEurope PMC citationsLicence / source
The outcome of intraoral onlay block bone grafts on alveolar ridge augmentations: a systematic review
Aloy-Prósper A, Peñarrocha-Oltra D, Peñarrocha-Diago M, Peñarrocha-Diago M
2015Systematic review
Design not recorded in structured metadata
74cc by
PMID 25662543 · DOI · PMC4393991
Effect of cavity preparation design and ceramic type on the stress distribution, strain and fracture resistance of CAD/CAM onlays in molars
Vianna ALSV, Prado CJD, Bicalho AA, Pereira RADS, Neves FDD, Soares CJ
2018Research article
Design not recorded in structured metadata
50cc by
PMID 30133672 · DOI · PMC6110459
Clinical performance of resin-matrix ceramic partial coverage restorations: a systematic review
Fathy H, Hamama HH, El-Wassefy N, Mahmoud SH
2022Systematic review
Design not recorded in structured metadata
46cc by
PMID 35320383 · DOI · PMC9072524
Effect of deep margin elevation with different injectable materials on performance of CAD/CAM-Fabricated nanoceramic-resin onlays: 3-year randomized clinical trial
Roshdy BN, Eltoukhy RI, Ali AI, Mahmoud SH
2026Randomized controlled trial
Design not recorded in structured metadata
2cc by
PMID 41498943 · DOI · PMC12779714

The outcome of intraoral onlay block bone grafts on alveolar ridge augmentations: a systematic review [1]

Systematic review Aloy-Prósper A, Peñarrocha-Oltra D, Peñarrocha-Diago M, Peñarrocha-Diago M · · 2015 · cited 74 times (Europe PMC)

Abstract reading summary — source excerpts
Opening excerpt
AimThe purpose of this study was to systematically review clinical studies examining the survival and success rates of implants placed with intraoral onlay autogenous bone grafts to answer the following question: do ridge augmentations procedures with intraoral onlay block bone grafts in conjunction with or prior to implant placement influence implant outcome when compared with a control group (guided bone regeneration, alveolar distraction, native bone or short dental implants.
Closing excerpt
More surgical challenges and morbidity arise from vertical augmentations, thus short implants may be a feasible option.
Interpretation limits
Verbatim excerpts from the authors’ abstract; the closing excerpt may describe a finding, limitation or recommendation. Design, population, effect size and uncertainty have not been independently extracted or appraised. Read the complete abstract and linked paper before interpreting the findings.
Read complete abstract (286 words)

AimThe purpose of this study was to systematically review clinical studies examining the survival and success rates of implants placed with intraoral onlay autogenous bone grafts to answer the following question: do ridge augmentations procedures with intraoral onlay block bone grafts in conjunction with or prior to implant placement influence implant outcome when compared with a control group (guided bone regeneration, alveolar distraction, native bone or short dental implants.)?Material and methodAn electronic data banks and hand searching were used to find relevant articles on vertical and lateral augmentation procedures performed with intraoral onlay block bone grafts for dental implant therapy published up to October 2013. Publications in English, on human subjects, with a controlled study design -involving at least one group with defects treated with intraoral onlay block bone grafts, more than five patients and a minimum follow-up of 12 months after prosthetic loading were included. Two reviewers extracted the data.ResultsA total of 6 studies met the inclusion criteria: 4 studies on horizontal augmentation and 2 studies on vertical augmentation. Intraoperative complications were not reported. Most common postsurgical complications included mainly mucosal dehiscences (4 studies), bone graft or membrane exposures (3 studies), complete failures of block grafts (2 studies) and neurosensory alterations (4 studies). For lateral augmentation procedures, implant survival rates ranged from 96.9% to 100%, while for vertical augmentation they ranged from 89.5% to 100%. None article studied the soft tissues healing.ConclusionsSurvival and success rates of implants placed in horizontally and vertically resorbed edentulous ridges reconstructed with block bone grafts are similar to those of implants placed in native bone, in distracted sites or with guided bone regeneration. More surgical challenges and morbidity arise from vertical augmentations, thus short implants may be a feasible option.

Abstract reproduced from the open-access article under the recorded cc by licence; © the authors. PMID 25662543 · DOI · PMC4393991

Effect of cavity preparation design and ceramic type on the stress distribution, strain and fracture resistance of CAD/CAM onlays in molars [2]

Research article Vianna ALSV, Prado CJD, Bicalho AA, Pereira RADS, Neves FDD, Soares CJ · · 2018 · cited 50 times (Europe PMC)

Abstract reading summary — source excerpts
Opening excerpt
Objective This study aimed to evaluate the effect of the cavity preparation and ceramic type on the stress distribution, tooth strain, fracture resistance and fracture mode of human molar teeth restored with onlays.
Closing excerpt
Conclusion Molars restored with lithium disilicate CAD-CAM ceramic onlays exhibited higher fracture resistance than molars restored with leucite CAD-CAM ceramic onlays.
Interpretation limits
Verbatim excerpts from the authors’ abstract; the closing excerpt may describe a finding, limitation or recommendation. Design, population, effect size and uncertainty have not been independently extracted or appraised. Read the complete abstract and linked paper before interpreting the findings.
Read complete abstract (292 words)

Objective This study aimed to evaluate the effect of the cavity preparation and ceramic type on the stress distribution, tooth strain, fracture resistance and fracture mode of human molar teeth restored with onlays. Material and Methods Forty-eight molars were divided into four groups (n=12) with assorted combinations of two study factors: BL- conventional onlay preparation with boxes made from leucite ceramic (IPS-Empress CAD, Ivoclar Vivadent); NBL- conservative onlay preparation without boxes made from leucite ceramic; BD- conventional onlay preparation with boxes made from lithium disilicate glass ceramic (IPS e.max CAD, Ivoclar Vivadent); NBL- conservative onlay preparation with boxes made from lithium disilicate glass ceramic cuspal deformation (µS) was measured at 100 N and at maximum fracture load using strain gauge. Fracture resistance (N) was measured using a compression test, and the fracture mode was recorded. Finite element analysis was used to evaluate the stress distribution by modified von Mises stress criteria. The tooth strain and fracture resistance data were analyzed using the Tukey test and two-way ANOVA, and the fracture mode was analyzed by the chi-square test (α=0.05). Results The leucite ceramic resulted in higher tooth deformation at 100 N and lower tooth deformation at the maximum fracture load than the lithium disilicate ceramic (P<0.001). The lithium disilicate ceramic exhibited higher fracture resistance than the leucite ceramic (P<0.001). The conservative onlay resulted in higher fracture strength for lithium disilicate ceramic. Finite element analysis results showed the conventional cavity preparation resulted in higher stress concentration in the ceramic restoration and remaining tooth than the conservative onlay preparation. The conservative onlays exhibited increased fracture resistance, reduced stress concentration and more favorable fracture modes. Conclusion Molars restored with lithium disilicate CAD-CAM ceramic onlays exhibited higher fracture resistance than molars restored with leucite CAD-CAM ceramic onlays.

Abstract reproduced from the open-access article under the recorded cc by licence; © the authors. PMID 30133672 · DOI · PMC6110459

Clinical performance of resin-matrix ceramic partial coverage restorations: a systematic review [3]

Systematic review Fathy H, Hamama HH, El-Wassefy N, Mahmoud SH · · 2022 · cited 46 times (Europe PMC)

Abstract reading summary — source excerpts
Opening excerpt
ObjectiveTo evaluate clinical performance of the new CAD/CAM resin-matrix ceramics and compare it with ceramic partial coverage restorations.
Closing excerpt
However, clinicians must be aware of the lake of knowledge regarding long-term outcome.
Interpretation limits
Verbatim excerpts from the authors’ abstract; the closing excerpt may describe a finding, limitation or recommendation. Design, population, effect size and uncertainty have not been independently extracted or appraised. Read the complete abstract and linked paper before interpreting the findings.
Read complete abstract (236 words)

ObjectiveTo evaluate clinical performance of the new CAD/CAM resin-matrix ceramics and compare it with ceramic partial coverage restorations.Materials and methodsAn electronic search of 3 databases (The National Library of Medicine (MEDLINE/PubMed), Scopus, and the Cochrane Central Register of Controlled Trials) was conducted. English clinical studies published between 2005 and September 2020 that evaluated the clinical performance of CAD/CAM resin-matrix ceramics inlays, onlays, or overlays were selected. The primary clinical question was applied according to PICOS strategy (Population, Intervention, Comparison, Outcome, Study design). The included studies were individually evaluated for risk of bias according to the modified Cochrane Collaboration tool criteria.ResultsA total of 7 studies were included according to the established inclusion and exclusion criteria. From the included studies, 6 were randomized clinical trials while one study was longitudinal observational study without control group. According to the results of the included studies, the success rate of CAD/CAM resin-based composite ranged from 85.7 to 100% whereas the success rate reported for ceramic partial coverage restorations ranged from 93.3 to 100%. Fractures and debondings are found to be the most common cause of restorations failure.ConclusionCAD/CAM resin-based composite can be considered a reliable material for partial coverage restorations with clinical performance similar to glass ceramic restorations. However, this result needs to be confirmed in long-term evaluations.Clinical relevanceCAD/CAM resin-based composites provide a potential alternative to ceramic indirect restorations. However, clinicians must be aware of the lake of knowledge regarding long-term outcome.

Abstract reproduced from the open-access article under the recorded cc by licence; © the authors. PMID 35320383 · DOI · PMC9072524

Effect of deep margin elevation with different injectable materials on performance of CAD/CAM-Fabricated nanoceramic-resin onlays: 3-year randomized clinical trial [4]

Randomized controlled trial Roshdy BN, Eltoukhy RI, Ali AI, Mahmoud SH · · 2026 · cited 2 times (Europe PMC)

Abstract reading summary — source excerpts
Opening excerpt
OBJECTIVE: To evaluate the effect of deep margin elevation (DME) with four different injectable restorative materials on the three-year clinical performance of nanoceramic-resin CAD/CAM onlay restorations.
Closing excerpt
CLINICAL RELEVANCE: Injectable restorative materials can provide adequate clinical performance as deep margin elevation materials for molars restored with nanoceramic-resin CAD/CAM onlays.
Interpretation limits
Verbatim excerpts from the authors’ abstract; the closing excerpt may describe a finding, limitation or recommendation. Design, population, effect size and uncertainty have not been independently extracted or appraised. Read the complete abstract and linked paper before interpreting the findings.
Read complete abstract (232 words)

OBJECTIVE: To evaluate the effect of deep margin elevation (DME) with four different injectable restorative materials on the three-year clinical performance of nanoceramic-resin CAD/CAM onlay restorations. MATERIALS AND METHODS: Sixty-four adult patients with subgingival, broad Class II carious molars indicated for onlay restorations were randomly assigned to four groups according to the injectable DME materials used: highly viscous glass ionomer (HVGI), high-filled injectable composite resin (ICR), resin-modified glass ionomer (RMGI), and bioactive ionic resin (BAIR). The proximal subgingival margins were repositioned to a supragingival level using the assigned materials; subsequently, all groups received nanoceramic-resin CAD/CAM onlay restorations. Gingival health and restorative performance were assessed over a three-year evaluation period using the Gingival Index (GI) and modified World Dental Federation (FDI) criteria. The collected data were statistically analyzed. RESULTS: All restorations were evaluated with a 100% recall rate and a 100% survival rate. For GI, assessment of scores across various evaluation periods within each group revealed a significant increase over time. Nevertheless, no significant differences were found among the tested groups at each evaluation period. Additionally, FDI evaluation criteria showed no significant differences. CONCLUSIONS: After three years, nanoceramic-resin CAD/CAM onlay restorations following deep margin elevation with injectable restorative materials demonstrated acceptable clinical behavior, with only a slight increase in gingival bleeding. CLINICAL RELEVANCE: Injectable restorative materials can provide adequate clinical performance as deep margin elevation materials for molars restored with nanoceramic-resin CAD/CAM onlays.

Abstract reproduced from the open-access article under the recorded cc by licence; © the authors. PMID 41498943 · DOI · PMC12779714

Key reviews and meta-analyses

The most cited review-type papers among PubMed’s best-match results for this heading, listed with bibliographic details only. Follow the links for the full text and access terms.

  • Research article Survival Rate of Resin and Ceramic Inlays, Onlays, and Overlays: A Systematic Review and Meta-analysis [5]
    Morimoto S, Rebello de Sampaio FB, Braga MM, Sesma N, Özcan M · J Dent Res · 2016 · cited 166 times (Europe PMC)
  • Research article Marginal and internal fit of CAD-CAM inlay/onlay restorations: A systematic review of in vitro studies [6]
    Goujat A, Abouelleil H, Colon P, Jeannin C, Pradelle N, Seux D, et al. · J Prosthet Dent · 2019 · cited 128 times (Europe PMC)
  • Research article Adhesive luting of indirect restorations [7]
    Krämer N, Lohbauer U, Frankenberger R · Am J Dent · 2000 · cited 98 times (Europe PMC)
  • Research article Surface treatment protocols in the cementation process of ceramic and laboratory-processed composite restorations: a literature review [8]
    Soares CJ, Soares PV, Pereira JC, Fonseca RB · J Esthet Restor Dent · 2005 · cited 65 times (Europe PMC)
  • Research article Clinical performance of CEREC ceramic inlays: a systematic review [9]
    Martin N, Jedynakiewicz NM · Dent Mater · 1999 · cited 61 times (Europe PMC)
  • Research article Conservative posterior ceramic restorations: a literature review [10]
    Banks RG · J Prosthet Dent · 1990 · cited 53 times (Europe PMC)

References

  1. Aloy-Prósper A, Peñarrocha-Oltra D, Peñarrocha-Diago M, Peñarrocha-Diago M. The outcome of intraoral onlay block bone grafts on alveolar ridge augmentations: a systematic review. . 2015. PMID 25662543 · DOI · PMC4393991
  2. Vianna ALSV, Prado CJD, Bicalho AA, Pereira RADS, Neves FDD, Soares CJ. Effect of cavity preparation design and ceramic type on the stress distribution, strain and fracture resistance of CAD/CAM onlays in molars. . 2018. PMID 30133672 · DOI · PMC6110459
  3. Fathy H, Hamama HH, El-Wassefy N, Mahmoud SH. Clinical performance of resin-matrix ceramic partial coverage restorations: a systematic review. . 2022. PMID 35320383 · DOI · PMC9072524
  4. Roshdy BN, Eltoukhy RI, Ali AI, Mahmoud SH. Effect of deep margin elevation with different injectable materials on performance of CAD/CAM-Fabricated nanoceramic-resin onlays: 3-year randomized clinical trial. . 2026. PMID 41498943 · DOI · PMC12779714
  5. Morimoto S, Rebello de Sampaio FB, Braga MM, Sesma N, Özcan M. Survival Rate of Resin and Ceramic Inlays, Onlays, and Overlays: A Systematic Review and Meta-analysis. J Dent Res. 2016. PMID 27287305 · DOI
  6. Goujat A, Abouelleil H, Colon P, Jeannin C, Pradelle N, Seux D, et al.. Marginal and internal fit of CAD-CAM inlay/onlay restorations: A systematic review of in vitro studies. J Prosthet Dent. 2019. PMID 30509548 · DOI
  7. Krämer N, Lohbauer U, Frankenberger R. Adhesive luting of indirect restorations. Am J Dent. 2000. PMID 11763920
  8. Soares CJ, Soares PV, Pereira JC, Fonseca RB. Surface treatment protocols in the cementation process of ceramic and laboratory-processed composite restorations: a literature review. J Esthet Restor Dent. 2005. PMID 16231493 · DOI
  9. Martin N, Jedynakiewicz NM. Clinical performance of CEREC ceramic inlays: a systematic review. Dent Mater. 1999. PMID 10483396 · DOI
  10. Banks RG. Conservative posterior ceramic restorations: a literature review. J Prosthet Dent. 1990. PMID 2194021 · DOI

About this article

Sources
NLM Medical Subject Headings (definition, synonyms); NCBI PubMed (counts, identifiers); Europe PMC (open-access abstracts and citation counts).
Verification
Every reference was resolved against PubMed on 2026-11-04; title, year and DOI matched.
Review state
automated source verified; no human expert review has been recorded yet.
Version
1, last updated 2026-11-04.

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At a glance

3,519
PubMed records on this heading
6%
published since 2020
188
review articles
130
randomized trials
10
verified references below

Counts come from PubMed on 2026-11-04; they show how much has been written, not how strong the evidence is.

Related topics See all →

  • CrownsDiagnostics and Medical Technology
  • Dental ProsthesisDiagnostics and Medical Technology
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  • DenturesDiagnostics and Medical Technology
  • Dental PulpAnatomy and Physiology

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