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Rectal Prolapse

Digestive System and Liver · NLM MeSH · updated 2026-11-04 · version 1

Citations verified against PubMedNot yet clinician-reviewed10 referencesApproximately 5 min read

Protrusion of the rectal mucous membrane through the anus.

Table of Contents

1. Definition2. Research landscape3. Reading the evidence4. Open-access studies5. Key reviews6. References7. About this article

Definition and research guide

This page combines a MeSH definition, publication statistics and selected research abstracts. It is a starting point for reading the literature, not a medical textbook or a systematic evidence review.

Content available: 4 complete abstracts (1,003 words), 10 references. Full article text is not stored or reproduced here; follow the PMID, DOI or PMC links to read the original sources and their access terms.

Definition

Protrusion of the rectal mucous membrane through the anus. There are various degrees: incomplete with no displacement of the anal sphincter muscle; complete with displacement of the anal sphincter muscle; complete with no displacement of the anal sphincter muscle but with herniation of the bowel; and internal complete with rectosigmoid or upper rectum intussusception into the lower rectum.

Definition: NLM Medical Subject Headings (MeSH) scope note (Public domain (U.S. National Library of Medicine); attribution requested). View the MeSH record.

Also known as: Prolapse, Rectal; Prolapses, Rectal; Rectal Prolapses; Anus Prolapse; Anus Prolapses; Prolapse, Anus; Prolapses, Anus.

Where it fits in the MeSH classification

Broader topics
Rectal Diseases; Pelvic Organ Prolapse

Research landscape

PubMed indexes 3,296 records tagged with the MeSH heading “Rectal Prolapse” (counts retrieved 2026-11-04). 388 of them (11.8%) were published from 2020 onward, and the busiest period so far is through 1999 with 1,595 records.

Reviews account for 370 records (11.2%) and meta-analyses for 35. Randomized controlled trials number 58 (1.8%) as a share of all records on the topic. Randomized trials make up only a small share of this literature, so much of what is known comes from laboratory, observational or descriptive work.

PubMed records by publication periodthrough 1999: 1,595 records; 2000-2009: 588 records; 2010-2019: 725 records; 2020 onward: 388 records1,595through 19995882000-20097252010-20193882020 onward
Records in PubMed indexed with this heading, by publication period. Real counts from NCBI E-utilities; the final period covers only part of the current year. Volume reflects how much has been published, not how strong the evidence is.
Show the data
PeriodRecords
through 19991,595
2000-2009588
2010-2019725
2020 onward388
Share of records by publication typeReviews: 11.2 percent; Meta-analyses: 1.1 percent; Randomized controlled trials: 1.8 percentReviews11.2% (370)Meta-analyses1.1% (35)Randomized controlled trials1.8% (58)
Share of all PubMed records on this heading that carry each publication type. Types overlap with other records, so the shares do not sum to 100%.
Publication-type chart data
Publication types among 3,296 PubMed records
TypeRecordsShare
Reviews37011.2%
Meta-analyses351.1%
Randomized controlled trials581.8%

Method: PubMed query "Rectal Prolapse"[MeSH Terms] with publication-type and date filters, retrieved 2026-11-04.

Reading the evidence in digestive system and liver

Gut and liver research ranges from laboratory studies of the microbiome to large trials of drugs and surgery. Symptoms such as pain, reflux or bowel change are reported by patients and overlap between conditions, and diet and microbiome studies are mostly observational. Check whether the study measured symptoms, tissue findings or long-term outcomes, how the diagnosis was made and how long people were followed. Nothing here replaces advice from a qualified clinician.

Evidence from open-access studies

These open-access studies come from PubMed’s best-match results for this heading (papers whose main topic it is), ranked here by citation count, with one recent addition. Each abstract is reproduced in full under its recorded open licence so that you can read the authors’ own words. They illustrate the literature; they are not a systematic summary of it. Citation counts measure attention, not reliability or clinical benefit.

Study comparison — selected abstracts, not a systematic review
Study / authorsYearSource label / designEurope PMC citationsLicence / source
Cost-analysis and quality of life after laparoscopic and robotic ventral mesh rectopexy for posterior compartment prolapse: a randomized trial
Mäkelä-Kaikkonen J, Rautio T, Ohinmaa A, Koivurova S, Ohtonen P, Sintonen H, et al.
2019Randomized controlled trial
Design not recorded in structured metadata
36cc by
PMID 31069557 · DOI · PMC6620369
Altemeier's procedure for complete rectal prolapse; outcome and function in 43 consecutive female patients
Trompetto M, Tutino R, Realis Luc A, Novelli E, Gallo G, Clerico G
2019Research article
Design not recorded in structured metadata
29cc by
PMID 30606166 · DOI · PMC6318906
Abdominal versus perineal approach for external rectal prolapse: systematic review with meta-analysis
Pellino G, Fuschillo G, Simillis C, Selvaggi L, Signoriello G, Vinci D, et al.
2022Meta-analysis
Design not recorded in structured metadata
22cc by
PMID 35390136 · DOI · PMC8989040
Surgeon preferences and practice patterns in rectopexy: Results of an international survey
Gialamas E, Uhe I, Tokoto PA, Liot E, Ris F, Wexner SD, et al.
2026Research article
Design not recorded in structured metadata
4cc by
PMID 41486360 · DOI · PMC12765771

Cost-analysis and quality of life after laparoscopic and robotic ventral mesh rectopexy for posterior compartment prolapse: a randomized trial [1]

Randomized controlled trial Mäkelä-Kaikkonen J, Rautio T, Ohinmaa A, Koivurova S, Ohtonen P, Sintonen H, et al. · · 2019 · cited 36 times (Europe PMC)

Abstract reading summary — source excerpts
Opening excerpt
BackgroundThe aim of this study was to assess, whether robotic-assistance in ventral mesh rectopexy adds benefit to laparoscopy in terms of health-related quality of life (HRQoL), cost-effectiveness and anatomical and functional outcome.
Closing excerpt
The effect on HRQoL is minor, with no differences between techniques.
Interpretation limits
Verbatim excerpts from the authors’ abstract; the closing excerpt may describe a finding, limitation or recommendation. Design, population, effect size and uncertainty have not been independently extracted or appraised. Read the complete abstract and linked paper before interpreting the findings.
Read complete abstract (287 words)

BackgroundThe aim of this study was to assess, whether robotic-assistance in ventral mesh rectopexy adds benefit to laparoscopy in terms of health-related quality of life (HRQoL), cost-effectiveness and anatomical and functional outcome.MethodsA prospective randomized study was conducted on patients who underwent robot-assisted ventral mesh rectopexy (RVMR) or laparoscopic ventral mesh rectopexy (LVMR) for internal or external rectal prolapse at Oulu University Hospital, Finland, recruited in February-May 2012. The primary outcomes were health care costs from the hospital perspective and HRQoL measured by the 15D-instrument. Secondary outcomes included anatomical outcome assessed by pelvic organ prolapse quantification method and functional outcome by symptom questionnaires at 24 months follow-up.ResultsThere were 30 females (mean age 62.5 years, SD 11.2), 16 in the RVMR group and 14 in the LVMR group. The surgery-related costs of the RVMR were 1.5 times higher than the cost of the LVMR. At 3 months the changes in HRQoL were 'much better' (RVMR) and 'slightly better' (LVMR) but declined in both groups at 2 years (RVMR vs. LVMR, p > 0.05). The cost-effectiveness was poor at 2 years for both techniques, but if the outcomes were assumed to last for 5 years, it improved significantly. The incremental cost-effectiveness ratio for the RVMR compared to LVMR was €39,982/quality-adjusted life years (QALYs) at 2 years and improved to €16,707/QALYs at 5 years. Posterior wall anatomy was restored similarly in both groups. The subjective satisfaction rate was 87% in the RVMR group and 69% in the LVMR group (p = 0.83).ConclusionsAlthough more expensive than LVMR in the short term, RVMR is cost-effective in long-term. The minimally invasive VMR improves pelvic floor function, sexual function and restores posterior compartment anatomy. The effect on HRQoL is minor, with no differences between techniques.

Abstract reproduced from the open-access article under the recorded cc by licence; © the authors. PMID 31069557 · DOI · PMC6620369

Altemeier's procedure for complete rectal prolapse; outcome and function in 43 consecutive female patients [2]

Research article Trompetto M, Tutino R, Realis Luc A, Novelli E, Gallo G, Clerico G · · 2019 · cited 29 times (Europe PMC)

Abstract reading summary — source excerpts
Opening excerpt
BackgroundThe aim of this retrospective study was to evaluate morbidity, mortality, postoperative function and recurrences in patients treated by Altemeier's rectosigmoidectomy for complete rectal prolapse in a referral center for pelvic floor functional disorders.
Closing excerpt
Recurrence of prolapse was 40% at four years.
Interpretation limits
Verbatim excerpts from the authors’ abstract; the closing excerpt may describe a finding, limitation or recommendation. Design, population, effect size and uncertainty have not been independently extracted or appraised. Read the complete abstract and linked paper before interpreting the findings.
Read complete abstract (310 words)

BackgroundThe aim of this retrospective study was to evaluate morbidity, mortality, postoperative function and recurrences in patients treated by Altemeier's rectosigmoidectomy for complete rectal prolapse in a referral center for pelvic floor functional disorders.MethodsPeri-operative data on 43 consecutive female patients were reviewed. At follow-up any change in pelvic floor function and recurrences were determined. Thirty four patients were assessed at a median interval of 49 (2-135) months, six being deceased for reason not related to the prolapse and three lost to follow-up.ResultsPost-operative complications at 30 days occurred in 18 patients (38%). Major complication occurred in only one patient that was pneumonia with lung failure. Major complications were not related to the ASA score, BMI or age [average age 76.4]. There was no post-operative mortality at 30 days. At long-term follow-up functional results demonstrate a statistically significant decrease in the Obstructive Defecation Syndrome (ODS) score, but no statistically significant changes in the Vaizey score, the International Consultation on Incontinence Questionnaire Short Form (ICIQ-SF) score and the urinary retention score. ODS score decreased with respect to levatorplasty and the change was statistically significant instead of Vaizey score in which were not. At the same follow-up there were 12 (35%) cases of recurrence with an estimated risk at 48 months of 40%. There were no statistically significant differences between patients with and without recurrence regarding age (p = 0.188), BMI (p = 0.864), ASA score (p = 0.433), previously repaired prolapse (p = 0.398), previous hysterectomy (p = 0.705), length of resected bowel (p = 0.126), and levatorplasty (p = 0.304). Patient satisfaction showed a mean of 8.8 and 6.4 respectively in patients without and with recurrences (p = 0.012).ConclusionsAltemeier's procedure had in our series low complications rate and no mortality. It offered improved evacuation in constipated patients while didn't improve fecal and urinary continence. Recurrence of prolapse was 40% at four years.

Abstract reproduced from the open-access article under the recorded cc by licence; © the authors. PMID 30606166 · DOI · PMC6318906

Abdominal versus perineal approach for external rectal prolapse: systematic review with meta-analysis [3]

Meta-analysis Pellino G, Fuschillo G, Simillis C, Selvaggi L, Signoriello G, Vinci D, et al. · · 2022 · cited 22 times (Europe PMC)

Abstract reading summary — source excerpts
Opening excerpt
BackgroundExternal rectal prolapse (ERP) is a debilitating condition in which surgery plays an important role.
Closing excerpt
Age at surgery and duration of follow-up are associated with increased risk of recurrence, which warrants adequate reporting of future studies on this topic.
Interpretation limits
Verbatim excerpts from the authors’ abstract; the closing excerpt may describe a finding, limitation or recommendation. Design, population, effect size and uncertainty have not been independently extracted or appraised. Read the complete abstract and linked paper before interpreting the findings.
Read complete abstract (204 words)

BackgroundExternal rectal prolapse (ERP) is a debilitating condition in which surgery plays an important role. The aim of this study was to evaluate the outcomes of abdominal approaches (AA) and perineal approaches (PA) to ERP.MethodsThis was a PRISMA-compliant systematic review with meta-analysis. Studies published between 1990 and 2021 were retrieved. The primary endpoint was recurrence at the last available follow-up. Secondary endpoints included factors associated with recurrence and function. All studies were assessed for bias using the Newcastle-Ottawa Scale and Cochrane tool.ResultsFifteen studies involving 1611 patients (AA = 817; PA = 794) treated for ERP were included, three of which were randomized controlled trials (RCTs; 114 patients (AA = 54; PA = 60)). Duration of follow-up ranged from 12 to 82 months. Recurrence in non-randomized studies was 7.7 per cent in AA versus 20.1 per cent in PA (odds ratio (OR) 0.29, 95 per cent confidence interval (c.i.) 0.17 to 0.50; P ConclusionThe overall risk of recurrence of ERP appears to be higher with PA versus AA. Incontinence is less frequent after AA but at the cost of increased constipation. Age at surgery and duration of follow-up are associated with increased risk of recurrence, which warrants adequate reporting of future studies on this topic.

Abstract reproduced from the open-access article under the recorded cc by licence; © the authors. PMID 35390136 · DOI · PMC8989040

Surgeon preferences and practice patterns in rectopexy: Results of an international survey [4]

Research article Gialamas E, Uhe I, Tokoto PA, Liot E, Ris F, Wexner SD, et al. · · 2026 · cited 4 times (Europe PMC)

Abstract reading summary — source excerpts
Opening excerpt
AimRectopexy is the preferred abdominal intervention for rectal prolapse.
Closing excerpt
The findings emphasise the need for updated international guidelines to harmonise technique selection and perioperative management in rectal prolapse surgery.
Interpretation limits
Verbatim excerpts from the authors’ abstract; the closing excerpt may describe a finding, limitation or recommendation. Design, population, effect size and uncertainty have not been independently extracted or appraised. Read the complete abstract and linked paper before interpreting the findings.
Read complete abstract (202 words)

AimRectopexy is the preferred abdominal intervention for rectal prolapse. Despite similar procedural steps - rectal mobilisation, prolapse reduction, and fixation - techniques vary widely, and onsensus on the optimal approach is lacking. This study aimed to assess global surgeon preferences and practices in rectopexy.MethodsAn international 28-item online survey was distributed between November 2023 and March 2024 through professional networks and social media. Questions addressed surgeon demographics, perioperative strategies, and technical approaches to rectopexy. Responses were analysed descriptively and stratified by region and specialty.ResultsA total of 226 surgeons from 36 countries across four continents completed the survey. Most respondents (79.6%) administered preoperative intravenous antibiotics, and 80.5% used some form of mechanical bowel preparation. Minimally invasive approaches predominated (81%), with laparoscopy being most common. Posterior dissection was preferred by 61.5%, while 38.5% favoured ventral (anterior) dissection. Two-thirds (68.1%) routinely used mesh, predominantly synthetic. Only 15% performed rectopexy as a day-case procedure. Regional and specialty-related variations were evident in approach, mesh type, and perioperative protocols.ConclusionThis international survey reveals marked variability in rectopexy practice worldwide. Despite common principles, surgeon preference and regional factors strongly influence decision-making. The findings emphasise the need for updated international guidelines to harmonise technique selection and perioperative management in rectal prolapse surgery.

Abstract reproduced from the open-access article under the recorded cc by licence; © the authors. PMID 41486360 · DOI · PMC12765771

Key reviews and meta-analyses

The most cited review-type papers among PubMed’s best-match results for this heading, listed with bibliographic details only. Follow the links for the full text and access terms.

  • Research article Surgical management of rectal prolapse [5]
    Madiba TE, Baig MK, Wexner SD · Arch Surg · 2005 · cited 189 times (Europe PMC)
  • Research article Postoperative complications after procedure for prolapsed hemorrhoids (PPH) and stapled transanal rectal resection (STARR) procedures [6]
    Pescatori M, Gagliardi G · Tech Coloproctol · 2008 · cited 172 times (Europe PMC)
  • Research article Systematic review on the procedure for prolapse and hemorrhoids (stapled hemorrhoidopexy) [7]
    Tjandra JJ, Chan MK · Dis Colon Rectum · 2007 · cited 149 times (Europe PMC)
  • Research article Systematic review on ventral rectopexy for rectal prolapse and intussusception [8]
    Samaranayake CB, Luo C, Plank AW, Merrie AE, Plank LD, Bissett IP · Colorectal Dis · 2010 · cited 122 times (Europe PMC)
  • Research article Surgical management of pelvic organ prolapse in women [9]
    Maher C, Baessler K, Glazener CM, Adams EJ, Hagen S · Cochrane Database Syst Rev · 2007 · cited 120 times (Europe PMC)
  • Research article Clinical Practice Guidelines for the Treatment of Rectal Prolapse [10]
    Bordeianou L, Paquette I, Johnson E, Holubar SD, Gaertner W, Feingold DL, et al. · Dis Colon Rectum · 2017 · cited 109 times (Europe PMC)

References

  1. Mäkelä-Kaikkonen J, Rautio T, Ohinmaa A, Koivurova S, Ohtonen P, Sintonen H, et al.. Cost-analysis and quality of life after laparoscopic and robotic ventral mesh rectopexy for posterior compartment prolapse: a randomized trial. . 2019. PMID 31069557 · DOI · PMC6620369
  2. Trompetto M, Tutino R, Realis Luc A, Novelli E, Gallo G, Clerico G. Altemeier's procedure for complete rectal prolapse; outcome and function in 43 consecutive female patients. . 2019. PMID 30606166 · DOI · PMC6318906
  3. Pellino G, Fuschillo G, Simillis C, Selvaggi L, Signoriello G, Vinci D, et al.. Abdominal versus perineal approach for external rectal prolapse: systematic review with meta-analysis. . 2022. PMID 35390136 · DOI · PMC8989040
  4. Gialamas E, Uhe I, Tokoto PA, Liot E, Ris F, Wexner SD, et al.. Surgeon preferences and practice patterns in rectopexy: Results of an international survey. . 2026. PMID 41486360 · DOI · PMC12765771
  5. Madiba TE, Baig MK, Wexner SD. Surgical management of rectal prolapse. Arch Surg. 2005. PMID 15655208 · DOI
  6. Pescatori M, Gagliardi G. Postoperative complications after procedure for prolapsed hemorrhoids (PPH) and stapled transanal rectal resection (STARR) procedures. Tech Coloproctol. 2008. PMID 18512007 · DOI · PMC2778725
  7. Tjandra JJ, Chan MK. Systematic review on the procedure for prolapse and hemorrhoids (stapled hemorrhoidopexy). Dis Colon Rectum. 2007. PMID 17380367 · DOI
  8. Samaranayake CB, Luo C, Plank AW, Merrie AE, Plank LD, Bissett IP. Systematic review on ventral rectopexy for rectal prolapse and intussusception. Colorectal Dis. 2010. PMID 19438880 · DOI
  9. Maher C, Baessler K, Glazener CM, Adams EJ, Hagen S. Surgical management of pelvic organ prolapse in women. Cochrane Database Syst Rev. 2007. PMID 17636742 · DOI
  10. Bordeianou L, Paquette I, Johnson E, Holubar SD, Gaertner W, Feingold DL, et al.. Clinical Practice Guidelines for the Treatment of Rectal Prolapse. Dis Colon Rectum. 2017. PMID 28991074 · DOI

About this article

Sources
NLM Medical Subject Headings (definition, synonyms); NCBI PubMed (counts, identifiers); Europe PMC (open-access abstracts and citation counts).
Verification
Every reference was resolved against PubMed on 2026-11-04; title, year and DOI matched.
Review state
automated source verified; no human expert review has been recorded yet.
Version
1, last updated 2026-11-04.

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At a glance

3,296
PubMed records on this heading
12%
published since 2020
370
review articles
58
randomized trials
10
verified references below

Counts come from PubMed on 2026-11-04; they show how much has been written, not how strong the evidence is.

Related topics See all →

  • Uterine ProlapseKidney, Urology and Women's Health
  • IntussusceptionDigestive System and Liver
  • CystoceleKidney, Urology and Women's Health
  • Celiac DiseaseDigestive System and Liver
  • ColitisDigestive System and Liver

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