The authors are grateful to Shona Methven for her help in developing the research protocol for this assessment and to Lara Kemp for her secretarial support.
Contributions of authors
Miriam Brazzelli (https://orcid.org/0000-0002-7576-6751) (Reader on Research) planned the systematic review of the clinical evidence, contributed to the statistical analyses and interpreted the results. She also oversaw and co-ordinated all aspects of this assessment.
Lorna Aucott (https://orcid.org/0000-0001-6277-7972) (Senior Statistician) conducted the statistical analyses.
Magaly Aceves-Martins (https://orcid.org/0000-0002-9441-142X), Clare Robertson (https://orcid.org/0000-0001-6019-6795) and Mari Imamura (https://orcid.org/0000-0003-4871-0354) (Research Fellows) selected relevant papers from the literature, and performed data extraction and risk-of-bias assessments for all included studies.
Elisabet Jacobsen (https://orcid.org/0000-0002-3211-936X) (Research Assistant) reviewed the evidence on the cost-effectiveness of the biomarkers under investigation, and contributed to the acquisition of input data and to the economic evaluation under the supervision of Dwayne Boyers.
Amudha Poobalan (https://orcid.org/0000-0002-6975-3874) (Senior Lecturer in Public Health) contributed to the data extraction and risk-of-bias assessments of included studies.
Paul Manson (https://orcid.org/0000-0002-1405-1795) (Information Specialist) developed and ran the literature searches, retrieved full-text copies of the selected papers and provided information support throughout the project.
Graham Scotland (https://orcid.org/0000-0001-5539-8819) (Reader on Research) provided senior advice and guidance on the development of the economic model.
Callum Kaye (https://orcid.org/0000-0002-6904-7048) (Consultant in Anaesthetics and Intensive Care Medicine) and Simon Sawhney (https://orcid.org/0000-0002-7960-4573) (Clinical Lecturer in Nephrology) provided expert advice and guidance on the clinical aspects of this assessment.
Dwayne Boyers (https://orcid.org/0000-0002-9786-8118) (Health Economist) developed the economic model, conducted cost-effectiveness analyses and interpreted the results.
All authors contributed to the writing of this report.
Publications
Jacobsen E, Sawhney S, Brazzelli M, Aucott L, Scotland G, Aceves-Martins M, et al. Cost-effectiveness and value of information analysis of NephroCheck and NGAL tests compared to standard care for the diagnosis of acute kidney injury. BMC Nephrol 2021;22:399.
Data-sharing statement
All technical data are included in the main text or as appendices to this report. All queries should be submitted to the corresponding author for consideration.
Disclaimers
This report presents independent research funded by the National Institute for Health Research (NIHR). The views and opinions expressed by authors in this publication are those of the authors and do not necessarily reflect those of the NHS, the NIHR, NETSCC, the HTA programme or the Department of Health and Social Care. If there are verbatim quotations included in this publication the views and opinions expressed by the interviewees are those of the interviewees and do not necessarily reflect those of the authors, those of the NHS, the NIHR, NETSCC, the HTA programme or the Department of Health and Social Care.