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Digitally enabled therapy for chronic tic disorders and Tourette Syndrome: a systematic review and economic evaluation · References

References

CC BY 4.0 · National Institute for Health and Care Research · approximately 9 min read

  1. Centers for Disease Control and Prevention. Prevalence of diagnosed Tourette syndrome in persons aged 6–17 years: United States, 2007. MMWR: Morb Mortal Wkly Rep 2009;58:581–5.19498335
  2. Robertson MM. The prevalence and epidemiology of Gilles de la Tourette syndrome. Part 1: the epidemiological and prevalence studies. J Psychosom Res 2008;65:461–72.18940377
  3. Apter A, Pauls DL, Bleich A, Zohar AH, Kron S, Ratzoni G, et al. An epidemiologic study of Gilles de la Tourette’s syndrome in Israel. Arch Gen Psychiatry 1993;50:734–8.8357298
  4. Szejko N, Robinson S, Hartmann A, Ganos C, Debes NM, Skov L, et al. European clinical guidelines for Tourette syndrome and other tic disorders-version 2.0. Part I: assessment. Eur Child Adolesc Psychiatry 2022;31:383–402.34661764
  5. American Psychiatric Association. Diagnostic and Statistical Manual of Mental Disorders. 5th edn. Washington, DC: American Psychiatric Publishing; 2022.
  6. Hirschtritt ME, Lee PC, Pauls DL, Dion Y, Grados MA, Illmann C, et al.; Tourette Syndrome Association International Consortium for Genetics. Lifetime prevalence, age of risk, and genetic relationships of comorbid psychiatric disorders in Tourette syndrome. JAMA Psychiatry 2015;72:325–33.25671412
  7. Bloch MH, Peterson BS, Scahill L, Otka J, Katsovich L, Zhang H, Leckman JF. Adulthood outcome of tic and obsessive-compulsive symptom severity in children with Tourette syndrome. Arch Pediatr Adolesc Med 2006;160:65–9.16389213
  8. Groth C, Mol Debes N, Rask CU, Lange T, Skov L. Course of Tourette syndrome and comorbidities in a large prospective clinical study. J Am Acad Child Adolesc Psychiatry 2017;56:304–12.28335874
  9. Bloch MH, Leckman JF. Clinical course of Tourette syndrome. J Psychosom Res 2009;67:497–501.19913654
  10. Yang C, Cheng X, Zhang Q, Yu D, Li J, Zhang L. Interventions for tic disorders: an updated overview of systematic reviews and meta analyses. Psychiatry Res 2020;287:112905.32163785
  11. Kurlan R, Como PG, Miller B, Palumbo D, Deeley C, Andresen EM, et al. The behavioral spectrum of tic disorders: a community-based study. Neurology 2002;59:414–20.12177376
  12. Pringsheim T, Okun MS, Müller-Vahl K, Martino D, Jankovic J, Cavanna AE, et al. Practice guideline recommendations summary: treatment of tics in people with Tourette syndrome and chronic tic disorders. Neurology 2019;92:896–906.31061208
  13. BMJ Best Practice. Tic Disorders. 2022. URL: https://bestpractice.bmj.com/topics/en-gb/970 (accessed 13 January 2024).
  14. Knight T, Steeves T, Day L, Lowerison M, Jette N, Pringsheim T. Prevalence of tic disorders: a systematic review and meta-analysis. Pediatr Neurol 2012;47:77–90.22759682
  15. Levine JLS, Szejko N, Bloch MH. Meta-analysis: adulthood prevalence of Tourette syndrome. Prog Neuropsychopharmacol Biol Psychiatry 2019;95:109675.31220521
  16. Conelea CA, Woods DW, Zinner SH, Budman CL, Murphy TK, Scahill LD, et al. The impact of Tourette syndrome in adults: results from the Tourette Syndrome Impact Survey. Community Ment Health J 2013;49:110–20.22052430
  17. Marino C, Khan K, Groom MJ, Hall SS, Anderson S, Mcnally E, et al. Patients’ experience of accessing support for tics from primary care in the UK: an online mixed-methods survey. BMC Health Serv Res 2023;23:788.37488511
  18. National Institute for Health and Care Excellence. Attention Deficit Hyperactivity Disorder: Diagnosis and Management (NG87). 2018. URL: www.nice.org.uk/guidance/ng87 (accessed 13 January 2024).
  19. National Institute for Health and Care Excellence. Autism Spectrum Disorder in under 19s: Recognition, Referral and Diagnosis (CG128). 2011. URL: www.nice.org.uk/Guidance/CG128 (accessed 13 January 2024).
  20. National Institute for Health and Care Excellence. Autism Spectrum Disorder in under 19s: Support and Management (CG170). 2013. URL: www.nice.org.uk/guidance/cg170 (accessed 13 January 2024).
  21. National Institute for Health and Care Excellence. Suspected Neurological Conditions: Recognition and Referral (NG127). 2019. URL: www.nice.org.uk/guidance/ng127 (accessed 13 January 2024).
  22. Müller-Vahl KR, Szejko N, Verdellen C, Roessner V, Hoekstra PJ, Hartmann A, Cath DC. European clinical guidelines for Tourette syndrome and other tic disorders: summary statement. Eur Child Adolesc Psychiatry 2022;31:377–82.34244849
  23. Steeves T, McKinlay BD, Gorman D, Billinghurst L, Day L, Carroll A, et al. Canadian guidelines for the evidence-based treatment of tic disorders: behavioural therapy, deep brain stimulation, and transcranial magnetic stimulation. Can J Psychiatry 2012;57:144–51.22398000
  24. Aberdeen Health Technology Assessment Group. Digitally Enabled Therapy for Chronic Tic Disorders and Tourette Syndrome in Children and Young People (GID-MT605): Final Protocol. University of Aberdeen: Aberdeen Centre for Evaluation; 2024. URL: www.nice.org.uk/guidance/hte25/documents/final-protocol-2 (accessed 15 June 2024).
  25. Andrén P, Jakubovski E, Murphy TL, Woitecki K, Tarnok Z, Zimmerman-Brenner S, et al. European clinical guidelines for Tourette syndrome and other tic disorders-version 2.0. Part II: psychological interventions. Eur Child Adolesc Psychiatry 2022;31:403–23.34313861
  26. Hollis C, Pennant M, Cuenca J, Glazebrook C, Kendall T, Whittington C, et al. Clinical effectiveness and patient perspectives of different treatment strategies for tics in children and adolescents with Tourette syndrome: a systematic review and qualitative analysis. Health Technol Assess 2016;20:1–450, vii.
  27. Whittington C, Pennant M, Kendall T, Glazebrook C, Trayner P, Groom M, et al. Practitioner review: treatments for Tourette syndrome in children and young people – a systematic review. J Child Psychol Psychiatry 2016;57:988–1004.27132945
  28. Roessner V, Plessen KJ, Rothenberger A, Ludolph AG, Rizzo R, Skov L, et al.; ESSTS Guidelines Group. European clinical guidelines for Tourette syndrome and other tic disorders. Part II: pharmacological treatment. Eur Child Adolesc Psychiatry 2011;20:173–96.21445724
  29. Kefalopoulou Z, Zrinzo L, Jahanshahi M, Candelario J, Milabo C, Beigi M, et al. Bilateral globus pallidus stimulation for severe Tourette’s syndrome: a double-blind, randomised crossover trial. Lancet Neurol 2015;14:595–605.25882029
  30. Jimenez-Shahed J. Design challenges for stimulation trials of Tourette’s syndrome. Lancet Neurol 2015;14:563–5.25882028
  31. Martinez-Ramirez D, Jimenez-Shahed J, Leckman JF, Porta M, Servello D, Meng FG, et al. Efficacy and safety of deep brain stimulation in Tourette syndrome: the International Tourette Syndrome Deep Brain Stimulation Public Database and Registry. JAMA Neurol 2018;75:353–9.29340590
  32. Iverson AM, Arbuckle AL, Song DY, Bihun EC, Black KJ. Median nerve stimulation for treatment of tics: a 4-week open trial with ecological momentary assessment. J Clin Med 2023;12:2545.37048629
  33. Hall CL, Davies EB, Andrén P, Murphy T, Bennett S, Brown BJ, et al.; ORBIT Trial team. Investigating a therapist-guided, parent-assisted remote digital behavioural intervention for tics in children and adolescents – ‘Online Remote Behavioural Intervention for Tics’ (ORBIT) trial: protocol of an internal pilot study and single-blind randomised controlled trial. BMJ Open 2019;9:e027583.
  34. Hollis C, Hall CL, Jones R, Marston L, Novere Marie Le, Hunter R, et al. Therapist-supported online remote behavioural intervention for tics in children and adolescents in England (ORBIT): a multicentre, parallel group, single-blind, randomised controlled trial. Lancet Psychiatry 2021;8:871–82.34480868
  35. Hollis C, Hall CL, Khan K, Le Novere M, Marston L, Jones R, et al. Online remote behavioural intervention for tics in 9- to 17-year-olds: the ORBIT RCT with embedded process and economic evaluation. Health Technol Assess 2023;27:1–120.
  36. Maiquez BM, Smith C, Dyke K, Chou CP, Kasbia B, McCready C, et al. A double-blind, sham-controlled, trial of home-administered rhythmic 10-Hz median nerve stimulation for the reduction of tics, and suppression of the urge-to-tic, in individuals with Tourette syndrome and chronic tic disorder. J Neuropsychol 2023;17:540–63.37133932
  37. Neurotherapeutics Ltd. Improving the Lives of People with Tourettes. URL: www.neupulse.co.uk/ (accessed 9 January 2024).
  38. Andrén P, Holmsved M, Ringberg H, Wachtmeister V, Isomura K, Aspvall K, et al. Therapist-supported Internet-delivered exposure and response prevention for children and adolescents with Tourette Syndrome: a randomized clinical trial. JAMA Netw Open 2022;5:e2225614.35969401
  39. Sterne JAC, Savović J, Page MJ, Elbers RG, Blencowe NS, Boutron I, et al. RoB 2: a revised tool for assessing risk of bias in randomised trials. BMJ 2019;366:l4898.31462531
  40. Morera Maiquez B, Sigurdsson HP, Dyke K, Clarke E, McGrath P, Pasche M, et al. Entraining movement-related brain oscillations to suppress tics in Tourette syndrome. Curr Biol 2020;30:2334–42.e3.32502412
  41. Andrén P, Sampaio F, Ringberg H, Wachtmeister V, Warnström M, Isomura K, et al. Internet-delivered exposure and response prevention for pediatric Tourette Syndrome: 12-month follow-up of a randomized clinical trial. JAMA Netw Open 2024;7:e248468.38700867
  42. Canadian Agency for Drugs and Technologies in Health. Telehealth Services for the Treatment of Psychiatric Issues: Clinical Effectiveness, Safety, and Guidelines (Rapid Review). Ottawa: CADTH; 2015. URL: www.cadth.ca/telehealth-services-treatment-psychiatric-issues-clinical-effectiveness-safety-and-guidelines (accessed 13 January 2024).
  43. Philips Z, Ginnelly L, Sculpher M, Claxton K, Golder S, Riemsma R, et al. Review of guidelines for good practice in decision-analytic modelling in health technology assessment. Health Technol Assess 2004;8:iii–v, ix.
  44. National Institute for Health and Care Excellence. Developing NICE Guidelines: The Manual (PMG20). Appendix H: Appraisal Checklists, Evidence Tables, GRADE and Economic Profiles. 2014. URL: www.nice.org.uk/process/pmg20/resources/appendix-h-appraisal-checklists-evidence-tables-grade-and-economic-profiles-pdf-8779777885 (accessed 13 January 2024).
  45. Husereau D, Drummond M, Petrou S, Carswell C, Moher D, Greenberg D, et al.; CHEERS Task Force. Consolidated Health Economic Evaluation Reporting Standards (CHEERS) statement. J Med Econ 2013;16:713–9.23521434
  46. Dang TTH, Rowell D, Liddle J, Coyne T, Silburn P, Connelly LB. Economic evaluation of deep-brain stimulation for Tourette’s syndrome: an initial exploration. J Neurol 2019;266:2997–3008.31485722
  47. Hollis C, Hall CL, Khan K, Jones R, Marston L, Le Novere M, et al. Long‐term clinical and cost‐effectiveness of a therapist‐supported online remote behavioural intervention for tics in children and adolescents: extended 12‐ and 18‐month follow‐up of a single‐blind randomised controlled trial. J Child Psychol Psychiatry 2023;64:941–51.36649686
  48. Page MJ, McKenzie JE, Bossuyt PM, Boutron I, Hoffmann TC, Mulrow CD, et al. The PRISMA 2020 statement: an updated guideline for reporting systematic reviews. BMJ 2021;372:n71.33782057
  49. National Institute for Health and Care Excellence. NICE Health Technology Evaluations: The Manual (PMG36). 2022. URL: www.nice.org.uk/process/pmg36/chapter/introduction-to-health-technology-evaluation (accessed 15 June 2024).
  50. Leckman JF, Riddle MA, Hardin MT, Ort SI, Swartz KL, Stevenson J, Cohen DJ. The Yale Global Tic Severity Scale: initial testing of a clinician-rated scale of tic severity. J Am Acad Child Adolesc Psychiatry 1989;28:566–73.2768151
  51. Office for National Statistics. National Life Tables: UK. 2024. URL: www.ons.gov.uk/peoplepopulationandcommunity/birthsdeathsandmarriages/lifeexpectancies/datasets/nationallifetablesunitedkingdomreferencetables (accessed 15 June 2024).
  52. National Institute for Health and Care Excellence. GID-MT605 Digitally Enabled Therapy for Chronic Tic Disorders and Tourette Syndrome Final Scope – Updated. London; Manchester: NICE; 2024. URL: www.nice.org.uk/guidance/gid-mt605/documents/final-scope (accessed 15 June 2024)
  53. Furber G, Segal L. The validity of the Child Health Utility instrument (CHU9D) as a routine outcome measure for use in child and adolescent mental health services. Health Qual Life Outcomes 2015;13:22.25890377
  54. Stevens K. The Child Health Utility 9D (CHU9D) A new paediatric preference based measure of health related quality of life. PRO Newsletter 2010;43:11–2.
  55. Stevens K. Assessing the performance of a new generic measure of health-related quality of life for children and refining it for use in health state valuation. Appl Health Econ Health Policy 2011;9:157–69.21506622
  56. Ara R, Brazier JE. Populating an economic model with health state utility values: moving toward better practice. Value Health 2010;13:509–18.20230546
  57. National Institute for Health and Care Excellence. The Guidelines Manual: Process and Methods (PMG6). London; Manchester: NICE; 2012. URL: www.nice.org.uk/process/pmg6/resources/the-guidelines-manual-pdf-2007970804933 (accessed 15 June 2024).
  58. Briggs AH, Ades AE, Price MJ. Probabilistic sensitivity analysis for decision trees with multiple branches: use of the Dirichlet distribution in a Bayesian framework. Med Decis Making 2003;23:341–50.12926584
  59. Tappenden P, Chilcott JB. Avoiding and identifying errors and other threats to the credibility of health economic models. PharmacoEconomics 2014;32:967–79.25027943
  60. Hall CL, Sanderson C, Brown BJ, et al. Opportunities and challenges of delivering digital clinical trials: lessons learned from a randomised controlled trial of an online behavioural intervention for children and young people. Trials. 2020;21(1):1011.33298127
  61. Hollis C, Hall CL, Khan K, et al. Long‐term clinical and cost‐effectiveness of a therapist‐supported online remote behavioural intervention for tics in children and adolescents: extended 12‐ and 18‐month follow‐up of a single‐blind randomised controlled trial. J Child Psychol Psychiatry. 2023;64(6):941‐51.36649686
  62. Khan K, Hollis C, Hall CL, et al. Protocol for the process evaluation of the Online Remote Behavioural Intervention for Tics (ORBIT) randomized controlled trial for children and young people. Trials. 2020;21(1):6.31898510
  63. Khan K, Hollis C, Hall CL, et al. Fidelity of delivery and contextual factors influencing children's level of engagement: process evaluation of the Online Remote Behavioral Intervention for Tics Trial. J Med Internet Res. 2021;23(6):e25470.34152270
  64. Khan K, Hollis C, Hall CL, et al. Factors influencing the efficacy of an online behavioural intervention for children and young people with tics: Process evaluation of a randomised controlled trial J Behav Cogn Ther. 2022;32(3):197–206.
  65. Andrén P, Aspvall K, De La Cruz LF, Wiktor P, Romano S, Andersson E, Murphy T, Isomura K, Serlachius E, Mataix-Cols D. Therapist-guided and parent-guided internet-delivered behaviour therapy for paediatric Tourette’s disorder: a pilot randomised controlled trial with long-term follow-up. BMJ open. 2019 Feb 1;9(2):e024685.
  66. Andrén P, Fernandez de la Cruz L, Isomura K, et al. Efficacy and cost-effectiveness of therapist-guided internet-delivered behaviour therapy for children and adolescents with Tourette syndrome: study protocol for a single-blind randomised controlled trial. Trials. 2021;22(1):669.34593015
← Interpretation of the evidence and conclusionsAdditional information →

Attribution. Dwayne Boyers; Moira Cruickshank; Mohammad Azharuddin; Paul Manson; Diane Swallow; Carl Counsell et al. (2026). Digitally enabled therapy for chronic tic disorders and Tourette Syndrome: a systematic review and economic evaluation. National Institute for Health and Care Research. Copyright © 2026 Boyers et al. Licensed under CC BY 4.0. NCBI Bookshelf NBK620596. CC BY 4.0. Original source ↗. Text reproduced from the Bookshelf XML without changing wording; figures, images and supplements are not reproduced.

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