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Implementing early rehabilitation and mobilisation for children in UK paediatric intensive care units: the PERMIT feasibility study · References

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CC BY 4.0 · National Institute for Health and Care Research · approximately 19 min read

  1. Ouzzani M, Hammady H, Fedorowicz Z, Elmagarmid A. Rayyan: a web and mobile app for systematic reviews. Syst Rev 2016;5(1):210.27919275
  2. Seo H-J, Kim SY, Lee YJ, Jang B-H, Park J-E, Sheen S-S, Hahn SK. A newly developed tool for classifying study designs in systematic reviews of interventions and exposures showed substantial reliability and validity. J Clin Epidemiol 2016;70:200–5.26408805
  3. Fiser DH. Assessing the outcome of pediatric intensive care. J Pediatr 1992;121(1):68–74.1625096
  4. Sterne JAC, Savović J, Page MJ, Elbers RG, Blencowe NS, Boutron I, et al. RoB 2: a revised tool for assessing risk of bias in randomised trials. BMJ 2019;366:l4898.31462531
  5. Sterne JAC, Hernán MA, Reeves BC, Savović J, Berkman ND, Viswanathan M, et al. ROBINS-I: a tool for assessing risk of bias in non-randomised studies of interventions. BMJ (Clin Res Ed) 2016;355:i4919.
  6. Slade SC, Dionne CE, Underwood M, Buchbinder R. Consensus on Exercise Reporting Template (CERT): explanation and elaboration statement. Br J Sports Med 2016;50(23):1428–37.27707738
  7. Abdulsatar F, Walker RG, Timmons BW, Choong K. ‘Wii-Hab’ in critically ill children: a pilot trial. J Pediatr Rehabil Med 2013;6(4):193–204.24705654
  8. Alqaqaa Y, Herbsman J, Folks T, O’Donnell S, Klien D, Seilikoff L, Ellen Sheldon M. Early mobilization in the pediatric intensive care unit. Crit Care Med 2018;46(Suppl. 1):649.
  9. Ames S, Fink E, Alessi L, Chrisman M. Implementation of Early Mobility Guidelines in a PICU: Evaluation of Adherence and Outcomes. Critical Care Medicine Conference: 48th Critical Care Congress of the Society of Critical Care Medicine, SCCM 2019;47(1 Suppl. 1).
  10. Betters KA, Hebbar KB, Farthing D, Griego B, Easley T, Turman H, et al. Development and implementation of an early mobility program for mechanically ventilated pediatric patients. J Crit Care 2017;41:303–8.28821360
  11. Choong K, Chacon M, Walker R, Al-Harbi S, Clark H, Al-Mahr G, et al. Early rehabilitation in critically ill children: a pilot study. Pediatr Crit Care Med 2014a;15(4):8.
  12. Choong K, Tran N, Clark H, Cupido C, Corsi DJ. Acute rehabilitation in critically ill children. J Pediatr Intensive Care 2012;1(4):183–92.31214407
  13. Colwell BRL, Williams CN, Kelly SP, Ibsen LM. Mobilization therapy in the pediatric intensive care unit: a multidisciplinary quality improvement initiative. Am J Crit Care 2018;27(3):194–203.29716905
  14. Cui LR, LaPorte M, Civitello M, Stanger M, Orringer M, Casey F 3rd, et al. Physical and occupational therapy utilization in a pediatric intensive care unit. J Crit Care 2017;40:15–20.28297684
  15. Fink EL, Beers SR, Houtrow AJ, Richichi R, Burns C, Doughty L, et al., PICU-Rehabilitation Study Group. Early protocolized versus usual care rehabilitation for pediatric neurocritical care patients: a randomized controlled trial. Pediatr Crit Care Med 2019;20(6):540–50.30707210
  16. Justice L, Malone K, Simsic J. Impact of a quality improvement intervention to promote early mobilization (WeeMove) in the pediatric CTICU. World J Pediatr Congenit Heart Surg 2019;10(2):NP10.
  17. Wieczorek B, Ascenzi J, Kim Y, Lenker H, Potter C, Shata NJ, et al. PICU up!: impact of a quality improvement intervention to promote early mobilization in critically ill children. Pediatr Crit Care Med J Soc Crit Care Med World Fed Pediatr Intensive Crit Care Soc 2016;17(12):e559–66.
  18. Kudchadkar SR, Nelliot A, Awojoodu R, Vaidya D, Traube C, Walker T, Needham DM, Prevalence of Acute Rehabilitation for Kids in the PICU (PARK-PICU) Investigators and the Pediatric Acute Lung Injury and Sepsis Investigators (PALISI) Network. Physical rehabilitation in critically ill children: a multicenter point prevalence study in the United States. Crit Care Med 2020;48(5):634–44.32168030
  19. Choong K, Al-Harbi S, Siu K, Wong K, Cheng J, Baird B, et al. Functional recovery following critical illness in children: the ‘wee-cover’ pilot study. Pediatr Crit Care Med J Soc Crit Care Med World Fed Pediatr Intensive Crit Care Soc 2015;16(4):310–18.
  20. Choong K, Awladthani S, Khawaji A, Clark H, Borhan A, Cheng J, et al. Early exercise in critically ill youth and children, a preliminary evaluation: the wEECYCLE pilot trial. Pediatr Crit Care Med J Soc Crit Care Med World Fed Pediatr Intensive Crit Care Soc 2017;18(11):e546–54.
  21. Choong K, Foster G, Fraser DD, Hutchison JS, Joffe AR, Jouvet PA, et al., Canadian Critical Care Trials Group. Acute rehabilitation practices in critically ill children: a multicenter study. Pediatr Crit Care Med 2014b;15(6):e270–9.24777303
  22. Alfarsi A, Awladthani S, Cupido C, Kho M, Krasevich K, Nanji J, et al. Liberation from PICU-acquired complications: bi-center implementation study. Pediatr Crit Care Med 2021;22:276.
  23. Kothari H, Panicucci T, Houston A, Cifra C, Badheka A. PADGO! a quality improvement intervention to improve measures of ICU liberation. Crit Care Med 2021;49(1):559.
  24. Choong K, Zorko D, Awojoodu R, Ducharme-Crevier L, Fontela P, Lee L, et al. Prevalence of acute rehabilitation for kids in the PICU: a Canadian multicenter point prevalence study (PARK-PICU Canada). Pediatr Crit Care Med 2021;22:68–9.33065733
  25. Curry A, Brown A, Williams S, Schwartzberg S, Parkhurst L, Butrum-Sullivan J, et al. Impact of an early mobility program in the hematologic oncologic PICU setting. Crit Care Med 2021;49(1):527.33555781
  26. Ganu S, Keeley S, Muir C, Maki K, Allan K, Tsiros M, et al. Early mobilisation in critically ill children: does routine patient screening change practice? Pediatr Crit Care Med 2021;22:59.
  27. Moerman D, Derycke E, Bednarek P, Hickmann C, Houtekie L, Haenecour A, et al. Feasibility and Safety of Early Mobilization in Critically Ill Children. Annals of Intensive Care Conference: French Intensive Care Society, International Congress Reanimation 2018;8(2 Suppl. 1).
  28. Roeseler J, Sottiaux T, Beduneau G, Bialais E, Bradai N, Castelain V, et al. Management of early mobilisation (including electrostimulation) in adult and pediatric patients in the intensive care unit. [French]. Reanimation 2013;22(2):207–18.
  29. Remondini R, Valerio N, Barcellos PG, do Prado C, Santos E. Early Mobilization in Children Underinvasive and Noninvasive Positive Pressure Ventilation: Description and Preliminary Results of a New Protocol. A56 Pediatric and Neonatal Critical Care. American Thoracic Society International Conference Abstracts: American Thoracic Society 2012:A1832.
  30. Redivo J, Nelliot A, Colleti Junior J, Kudchadkar S. Physical rehabilitation in Brazilian pediatric ICUS: a multicenter point prevalence study. Pediatr Crit Care Med 2021;22:61–61.
  31. Carlisi E, Pavese C, Mandrini S, Carenzio G, Dalla Toffola E. Early rehabilitative treatment for pediatric acute disseminated encephalomyelitis: case report. Eur J Phys Rehabil Med 2015;51(3):341–3.24937355
  32. Tsuboi N, Nozaki H, Ishida Y, Kanazawa I, Inamoto M, Hayashi K, et al. Early mobilization after pediatric liver transplantation. J Pediatr Intensive Care 2017;6(3):199–205.31073448
  33. Takaada K, Kikuchi N, Sashika H. Effectiveness of early phase rehabilitation for pediatric and adolescent traumatic brain injury patients in the critical care and emergency unit. Brain Inj 2012;26(4–5):428.
  34. Amao R, Imamura T, Sawada Y, Endo S, Ozaki S, Okamura K, et al. Experiences with aggressive cardiac rehabilitation in pediatric patients receiving mechanical circulatory supports. Int Heart J 2016;57(6):769–72.27829640
  35. Van Den Adel T, Hoekstra S, Steenhorst J, De Heer M, Floor P, Ista E, et al. Quality improvement intervention to promote early mobilization in critically ill children. Pediatr Crit Care Med 2021;22:58.
  36. Coskun-Benlidayi I, Basaran S, Gul-Mert G, Guzel R. Early rehabilitation of a child with intensive care unit acquired weakness secondary to membranoproliferative glomerulonephritis: a case report. Turk J Pediatr 2015;57(4):422–5.27186711
  37. Ergene T, Karadibak D. Early physiotherapy program in pediatric liver transplant recipients. Fizyoterapi Rehabilitasyon 2018;29(1):S14.
  38. Sargent S, Sharp K, Hills J, Johnstone B. Paediatric In-bed Cycling: A Safety and Feasibility Evaluation in Intensive Care. Intensive Care Medicine Experimental Conference: 30th Annual Congress of the European Society of Intensive Care Medicine, ESICM 2017;5(2 Suppl. 1).
  39. McGibbon L, Johnstone B, Hills J, Sharp K. Mobilising within the Paediatric Intensive Care Unit – A Service Evaluation. Intensive Care Medicine Experimental Conference: 30th Annual Congress of the European Society of Intensive Care Medicine, ESICM 2017;5(2).
  40. Carter L, Woyda J, Shkurka E. GOSH Go! a service evaluation investigating early rehabilitation on cardiac intensive care (CICU). Arch Dis Child 2020;105:A6.
  41. Wood A, Khan U, Piper I, Van Dijke M, Lenathen C, Reilly L, Lo TYM. Sparking paediatric activity in critical care Edinburgh (S.P.A.C.E): how staff perceptions and current practice shape the development of a novel early mobilisation programme. Pediatr Crit Care Med 2021;22:325.
  42. Ista E, Scholefield B, Manning J, Harth I, Gawronski O, Bartkowska-Sniatkowska A, et al. Physical rehabilitation in critically ill children: a European point prevalence study. Pediatr Crit Care Med 2021;22:65.
  43. Choong K, Awladthani S, Khawaji A, Clark H, Borhan A, Cheng J, et al. Canadian Critical Care Trials Group. Early exercise in critically ill youth and children, a preliminary evaluation: the wEECYCLE pilot trial. Pediatr Crit Care Med 2017;18(11):e546–54.28922268
  44. Remondini R, Valerio N, Barcellos PG, Do Prado C, Santos E. Early Mobilization in Children under Invasive and Noninvasive Positive Pressure Ventilation: Description and Preliminary Results of a New Protocol. American Journal of Respiratory and Critical Care Medicine Conference: American Thoracic Society International Conference, ATS 2012;185 (Meeting Abstracts)
  45. McGibbon L, Johnstone B, Hills J, Sharp K. Mobilising within the paediatric intensive care unit-a service evaluation. Intensive Care Medicine Experimental Conference: 30th Annual Congress of the European Society of Intensive Care Medicine, ESICM 2017;5(2 Suppl. 1)
  46. Child H, Scholefield B, Menzies J. An early evaluation of the utility of the MOTOmed supine bike in a UK paediatric intensive care (PIC). Pediatr Crit Care Med 2018;19(6S):194.
  47. Fink EL, Maddux AB, Pinto N, Sorenson S, Notterman D, Dean JM, et al. Pediatric Outcomes STudies after PICU (POST-PICU) Investigators of the Pediatric Acute Lung Injury and Sepsis Investigators (PALISI) Network and the Eunice Kennedy Shriver National Institute of Child Health and Human Development Collaborative Pediatric Critical Care Research Network (CPCCRN). A core outcome set for pediatric critical care. Crit Care Med 2020;48(12):1819–28.33048905
  48. Jedrzejewska A, Dobosiewicz K, Ickowicz I, Majka W, Flak M, Szota M, et al. [Rehabilitation of children after craniocerebral injuries with particular attention paid to the reflex stimulation Powiertowski’s method. Preliminary study]. Wiad Lek 2009;62(1):3–10.19817250
  49. Tepas JJ 3rd, Leaphart CL, Pieper P, Beaulieu CL, Spierre LR, Tuten JD, Celso BG. The effect of delay in rehabilitation on outcome of severe traumatic brain injury. J Pediatr Surg 2009;44(2):368–72.19231536
  50. Joyce CL, Taipe C, Sobin B, Spadaro M, Gutwirth B, Elgin L, et al. Provider beliefs regarding early mobilization in the pediatric intensive care unit. J Pediatr Nurs 2018;38:15–19.29167075
  51. Hatem TP, Lira PI, Mattos SS. The therapeutic effects of music in children following cardiac surgery. J Pediatr 2006;82(3):186–92.
  52. Melchers P, Maluck A, Suhr L, Scholten S, Lehmkuhl G. An early onset rehabilitation program for children and adolescents after Traumatic Brain Injury (TBI): methods and first results. Restor Neurol Neurosci 1999;14(2–3):153–60.
  53. Cameron S, Ball I, Cepinskas G, Choong K, Doherty TJ, Ellis CG, et al. Early mobilization in the critical care unit: a review of adult and pediatric literature. J Crit Care 2015;30(4):664–72.25987293
  54. Connolly B, O’Neill B, Salisbury L, Blackwood B, Enhanced Recovery After Critical Illness Programme Group. Physical rehabilitation interventions for adult patients during critical illness: an overview of systematic reviews. Thorax 2016;71(10):881–90.27220357
  55. Cuello-Garcia CA, Mai SHC, Simpson R, Al-Harbi S, Choong K. Early mobilization in critically ill children: a systematic review. J Pediatr 2018;203:25–33.e6.30172429
  56. Walker T, Kudchadkar SR. Early mobility in the pediatric intensive care unit: can we move on? J Pediatr 2018;203:10–12.30270161
  57. Hills J, Sharp K, Johnstone B. Move on ventilation early (MOVE): an early mobility quality improvement initiative. Pediatr Crit Care Med 2018;19(6S):198.
  58. Mayring P. Qualitative content analysis. Forum Qualitative Sozialforschung/Forum: Qual Soc Res 2000;1(2):Art. 20. URL: http://nbn-resolving.de/urn:nbn:de:0114-fqs0002204 [accessed September 2020].
  59. Bengtsson M. How to plan and perform a qualitative study using content analysis. NursingPlus Open 2016;2:8–14.
  60. Vaismoradi M, Turunen H, Bondas T. Content analysis and thematic analysis: implications for conducting a qualitative descriptive study. Nurs Health Sci 2013;15(3):398–405.23480423
  61. Burnard P. A method of analysing interview transcripts in qualitative research. Nurse Educ Today 1991;11(6):461–6.1775125
  62. PICANet. Paediatric Intensive Care Audit Network National Annual Report 2016–2018. 2019. URL: www.picanet.org.uk/annual-reporting-and-publications/ (accessed 15 September 2020).
  63. Fiser DH, Long N, Roberson PK, Hefley G, Zolten K, Brodie-Fowler M. Relationship of pediatric overall performance category and pediatric cerebral performance category scores at pediatric intensive care unit discharge with outcome measures collected at hospital discharge and 1- and 6-month follow-up assessments. Crit Care Med 2000;28(7):2616–20.10921604
  64. Leteurtre S, Duhamel A, Salleron J, Grandbastien B, Lacroix J, Leclerc F, Groupe Francophone de Réanimation et d’Urgences Pédiatriques (GFRUP). PELOD-2: an update of the pediatric logistic organ dysfunction score. Crit Care Med 2013;41(7):1761–73.23685639
  65. Hanley JA, Lippman-Hand A. If nothing goes wrong, is everything all right? Interpreting zero numerators. JAMA 1983;249(13):1743–5.6827763
  66. Blackwood B, Tume LN, Morris KP, Clarke M, McDowell C, Hemming K, et al., SANDWICH Collaborators. Effect of a sedation and ventilator liberation protocol vs usual care on duration of invasive mechanical ventilation in pediatric intensive care units: a randomized clinical trial. JAMA 2021;326(5):401–10.34342620
  67. PICANet. Paediatric Intensive Care Audit Network Annual Report 2021. Data collection period 2018-2020 2022. URL: www.picanet.org.uk/wp-content/uploads/sites/25/2022/01/PICANet-2021-Annual-Report_v1.0-13Jan2022-2.pdf (accessed 28 March 2022).
  68. Skivington K, Matthews L, Simpson SA, Craig P, Baird J, Blazeby JM, et al. A new framework for developing and evaluating complex interventions: update of Medical Research Council guidance. BMJ (Clin Res Ed) 2021;374:n2061.
  69. Craig P, Dieppe P, Macintyre S, Michie S, Nazareth I, Petticrew M, Medical Research Council Guidance. Developing and evaluating complex interventions: the new Medical Research Council guidance. BMJ (Clin Res Ed) 2008;337:a1655.
  70. Campbell M, Fitzpatrick R, Haines A, Kinmonth AL, Sandercock P, Spiegelhalter D, Tyrer P. Framework for design and evaluation of complex interventions to improve health. BMJ (Clin Res Ed) 2000;321(7262):694–6.
  71. May C, Finch T. Implementing, embedding, and integrating practices: an outline of normalization process theory. Sociology 2009;43(3):535–54.
  72. May CR, Mair F, Finch T, MacFarlane A, Dowrick C, Treweek S, et al. Development of a theory of implementation and integration: normalization process theory. Implement Sci 2009;4(1):29.19460163
  73. Sekhon M, Cartwright M, Francis JJ. Acceptability of healthcare interventions: an overview of reviews and development of a theoretical framework. BMC Health Serv Res 2017;17(1):88.28126032
  74. Powell BJ, Waltz TJ, Chinman MJ, Damschroder LJ, Smith JL, Matthieu MM, et al. A refined compilation of implementation strategies: results from the Expert Recommendations for Implementing Change (ERIC) project. Implement Sci 2015;10(1):21.25889199
  75. Johnston M, Carey RN, Connell Bohlen LE, Johnston DW, Rothman AJ, de Bruin M, et al. Development of an online tool for linking behavior change techniques and mechanisms of action based on triangulation of findings from literature synthesis and expert consensus. Transl Behav Med 2020;11(5):1049–65.
  76. Yardley L, Morrison L, Bradbury K, Muller I. The person-based approach to intervention development: application to digital health-related behavior change interventions. J Med Internet Res 2015;17(1):e30.25639757
  77. Bradbury K, Morton K, Band R, van Woezik A, Grist R, McManus RJ, et al. Using the person-based approach to optimise a digital intervention for the management of hypertension. PLOS ONE 2018;13(5):e0196868.29723262
  78. Duffett M, Cook DJ, Strong G, Lee JH, Kho ME. The effect of COVID-19 on critical care research during the first year of the pandemic: a prospective longitudinal multinational survey. medRxiv 2021. 10.1101/2020.10.21.20216945
  79. Hoffmann TC, Glasziou PP, Boutron I, Milne R, Perera R, Moher D, et al. Better reporting of interventions: template for intervention description and replication (TIDieR) checklist and guide. BMJ 2014;348:g1687.24609605
  80. Rapley T. Some pragmatics of data analysis. In Silverman D, editor. Qualitative Research. 5th edn. London: Sage; 2011. pp. 273–90.
  81. O’Connor G, Marino LV, Tume LN, Stewart A, Gates S, Lanigan J, et al. Research priorities for pediatric intensive care nutrition within the United Kingdom: a National Institute of Health Research James Lind Alliance Priority Setting Partnership. Crit Care Explor 2022;4(3):e0649.35265852
  82. Semple D, Howlett MM, Strawbridge JD, Breatnach CV, Hayden JC. A systematic review and pooled prevalence of delirium in critically ill children. Crit Care Med 2022;50(2):317–28.34387241
  83. Ista E, Nydahl P. Delirium in adult and paediatric ICU patients: what is the way forward? Nurs Crit Care 2021;26(3):147–9.34009748
  84. Manning JC, Pinto NP, Rennick JE, Colville G, Curley MAQ. Conceptualizing post intensive care syndrome in children – the PICS-p framework. Pediatr Crit Care Med 2018;19(4):298–300.29406379
  85. Piva TC, Ferrari RS, Schaan CW. Early mobilization protocols for critically ill pediatric patients: systematic review. Rev Bras Ter Intensiva 2019;31(2):248–57.31215603
  86. Choong K, Canci F, Clark H, Hopkins RO, Kudchadkar SR, Lati J, et al. Practice Recommendations for early mobilization in critically ill children. J Pediatr Intensive Care 2018;7(1):14–26.31073462
  87. Murray E, Treweek S, Pope C, MacFarlane A, Ballini L, Dowrick C, et al. Normalisation process theory: a framework for developing, evaluating and implementing complex interventions. BMC Med 2010;8:63.20961442
  88. World Health Organization International Classification of Functioning, Disability and Health: ICF. Geneva: World Health Organization; 2001.
  89. Clarissa C, Salisbury L, Rodgers S, Kean S. Early mobilisation in mechanically ventilated patients: a systematic integrative review of definitions and activities. J Intensive Care 2019;7(1):3.30680218
  90. Amidei C. Mobilisation in critical care: a concept analysis. Intensive Crit Care Nurs 2012;28(2):73–81.22326102
  91. Weinreich M, Herman J, Dickason S, Mayo H. Occupational therapy in the intensive care unit: a systematic review. Occup Ther Health Care 2017;31(3):205–13.28692383
  92. Costigan FA, Duffett M, Harris JE, Baptiste S, Kho ME. Occupational therapy in the ICU: a scoping review of 221 documents. Crit Care Med 2019;47(12):e1014–21.31738741
  93. Bittencourt ES, Moreira PS, Paixão GM, Cardoso MM. The role of the occupational therapist in the Intensive Care Unit: a systematic review. Cad Bras Ter Ocup 2021;29:1–21.
  94. Lavallée A, De Clifford-Faugère G, Garcia C, Fernandez Oviedo AN, Héon M, Aita M. Part 1: narrative overview of developmental care interventions for the preterm newborn. J Neonatal Nurs. 2019;25(1):3–8.
  95. Khurana S, Kane AE, Brown SE, Tarver T, Dusing SC. Effect of neonatal therapy on the motor, cognitive, and behavioral development of infants born preterm: a systematic review. Dev Med Child Neurol 2020;62(6):684–92.32077096
  96. Royal College of Occupational Therapists. Occupational Therapy in Neonatal Services and Early Intervention - Practice Guideline. Royal College of Occupational Therapists; 2017. URL: https://www.rcot.co.uk/practice-resources/rcot-publications/downloads/neonatal-services [acessed 15 September 2020].
  97. Hodgson CL, Stiller K, Needham DM, Tipping CJ, Harrold M, Baldwin CE, et al. Expert consensus and recommendations on safety criteria for active mobilization of mechanically ventilated critically ill adults. Crit Care 2014;18(6):658.25475522
  98. Sakai T, Hoshino C, Okawa A, Wakabayashi K, Shigemitsu H. The safety and effect of early mobilization in the intensive care unit according to cancellation criteria. Prog Rehabil Med 2020;5:20200016.32844129
  99. Fink EL, Jarvis JM, Maddux AB, Pinto N, Galyean P, Olson LM, et al., Pediatric Acute Lung Injury and Sepsis Investigators (PALISI) Long-term Outcomes Subgroup Investigators, and Eunice Kennedy Shriver National Institute of Child Health and Human Development Collaborative Pediatric Critical Care Research Network (CPCCRN). Development of a core outcome set for pediatric critical care outcomes research. Contemp Clin Trials 2020;91:105968.32147572
  100. Duffett M, Cook DJ, Strong G, Binf M, Hau Lee J, Kho ME. The pre-print sever for health sciences. The effect of COVID-19 on critical care research during the first year of the pandemic: A prospective longitudinal multinational survey. medRxiv 2020. 10.1101/2020.10.21.20216945
  101. Manning JC, Latour JM, Curley MAQ, Draper ES, Jilani T, Quinlan PR, et al. OCEANIC Study Investigators. Study protocol for a multicentre longitudinal mixed methods study to explore the Outcomes of ChildrEn and fAmilies in the first year after paediatric Intensive Care: the OCEANIC study. BMJ Open 2020;10(5):e038974.
  102. Drury NE, Menzies JC, Taylor CJ, Jones TJ, Lavis AC. Understanding parents’ decision-making on participation in clinical trials in children’s heart surgery: a qualitative study. BMJ Open 2021;11(2):e044896.
  103. Ely EW. The ABCDEF bundle: science and philosophy of how ICU liberation serves patients and families. Crit Care Med 2017;45(2):321–30.28098628
  104. Finch TL, Girling M, May CR, Mair FS, Murray E, Treweek S, et al. Improving the normalization of complex interventions: part 2 - validation of the NoMAD instrument for assessing implementation work based on normalization process theory (NPT). BMC Med Res Methodol 2018;18(1):135.30442094
  105. Gale N, Heath G, Cameron E, Rashid S, Redwood S. Using the framework method for the analysis of qualitative data in multi-disciplinary health. BMC Med Res Methodol 2013;13(117):1–8.23297754
  106. Palinkas LA, Horwitz SM, Green CA, Wisdom JP, Duan N, Hoagwood K. Purposeful sampling for qualitative data collection and analysis in mixed method implementation research. Adm Policy Ment Health 2015;42(5):533–44.24193818
  107. Green J, Thorogood N. Qualitative Methods for Health Research. 2nd edn. Thousand Oaks: Sage; 2009.
  108. DeSantis L, Ugarriza DN. The concept of theme as used in qualitative nursing research. West J Nurs Res 2000;22(3):351–72.10804897
  109. Braun V, Clarke V. Using thematic analysis in psychology. Qual Res Psychol 2006;3:77–101.
  110. Gale N, Heath G, Cameron E, Rashid S, Redwood S. Using the framework method for the analysis of qualitative data in multi-disciplinary health. BMC Med Res Methodol 2013;13:117.24047204
  111. Ritchie J. The applications of qualitative research to social research. In: Ritchie JC, Lewis, J, editors. Qualitative Research Practice: A Guide for Social Science Students and Researchers. London: Sage; 2003.
  112. Kudchadkar SR. PICU Up!: A pilot stepped-wedge trial of a multicomponent early mobility intervention for critically ill children (PICU Up!). Clinicaltrialsgov [Internet] 2022. URL: https://clinicaltrials.gov/ct2/show/NCT03860168 (accessed 1 April 2022).
  113. Blackwood B, Agus A, Boyle R, Clarke M, Hemming K, Jordan J, et al., Paediatric Intensive Care Society Study Group (PICS-SG). Sedation AND Weaning In Children (SANDWICH): protocol for a cluster randomised stepped wedge trial. BMJ Open 2019;9(11):e031630.
  114. Chiche JD, Angus DC. Testing protocols in the intensive care unit: complex trials of complex interventions for complex patients. JAMA 2008;299:693–5.18270360
  115. Bagley HJ, Short H, Harman NL, Hickey HR, Gamble CL, Woolfall K, et al. A patient and public involvement (PPI) toolkit for meaningful and flexible involvement in clinical trials – a work in progress. Res Involv Engagem 2016;2:15.29062516
  116. Hanley B, Bradburn J, Barnes M, Evans C, Goodare H, Kelson M, et al. Involving the Public in NHS, Public Health and Social Care Research: Briefing Notes for Researchers. 2nd edn. Hampshire: INVOLVE; 2004.
  117. Forbat L, Hubbard G, Kearney N. Patient and public involvement: models and muddles. J Clin Nurs 2008;18:2547–54.
  118. Menzies J, Morris K, Duncan H, Marriott J. Patient and public involvement in Paediatric Intensive Care research: considerations, challenges and facilitating factors. Res Invol Engagem 2016;2(32). URL: https://researchinvolvement.biomedcentral.com/articles/10.1186/s40900-016-0046-7#citeas [accessed 15 September 2020].
  119. Hoddinott P, Pollock A, O’Cathain A, Boyer I, Taylor J, MacDonald C, et al. How to incorporate patient and public perspectives into the design and conduct of research. F1000Research 2018;7(752):752.30364075
  120. Bioethics. NC. Children and Clinical Research: Ethical Issues. London: Nuffield Council on Bioethics; 2015.
  121. Conroy E, Harman N, Lane JA, Lewis SC, Murray G, Norrie J, et al. Trial Steering Committees in randomised controlled trials: a survey of registered clinical trials units to establish current practice and experiences. Clin Trials 2015;12(6):664–76.26085545
  122. Dudley L, Gamble C, Allam A, Bell P, Buck D, Goodare H, et al. A little more conversation please? Qualitative study of researchers’ and patients’ interview accounts of training for patient and public involvement in clinical trials. Trials 2015;16:190.25928689
  123. Kleiber N, Tromp K, Mooii M, van de Vathorst S, Tibboel D, de Wildt, S. Ethics of drug research in the Pediatric Intensive Care Unit. Paediatr Drugs 2015;17(1):43–53.25354987
  124. Tume L, Preston J, Blackwood B. Parents’ and young people’s involvement in designing a trial of ventilator weaning. Nurs Crit Care 2015;21(3):e10–18.26486094
  125. CONNECT Advisory Group. The CONNECT Study. Research Without Prior Consent (Deferred Consent) in Trials Investigating the Emergency Treatment of Critically Ill Children: CONNECT Study Guidance. Liverpool: Wellcome Trust; 2015.
  126. Woolfall K, Frith L, Dawson A, Gamble C, Lyttle MD, the CONNECT advisory group, Young B. Fifteen-minute consultation: an evidence based approach to research without prior consent (deferred consent) in neonatal and paediatric critical care trials. Arch Dis Child Educ Pract 2016;101:49–53.
  127. Lyttle M, O’Sullivan R, Hartshorn S, Bevan C, Cleugh F, Maconochie I, et al. LETTER Pediatric Emergency Research in the UK and Ireland (PERUKI): developing a collaborative for multicentre research. Arch Dis Child 2014;0:1–2.
  128. Menzies JC, Owen S, Read N, Fox S, Tooke C, Winmill H. COVID-19: challenges and opportunities for research nursing and nursing research on paediatric intensive care. Nurs Crit Care 2020;25:321–3.32679622
  129. INVOLVE. Briefing Notes for Researchers. Eastleigh: INVOLVE; 2012.
  130. NIHR. Generation R Young People Improving Research: 2013 Meeting Report. London: National Institute for Health Research; 2014.
  131. Birmingham Women’s and Children’s NHS Foundation Trust. Young Persons’ Advisory Group 2022. URL: https://bwc.nhs.uk/ypag/ (accessed 28 March 2022).
  132. Manning JC, Latour JM, Curley MAQ, Draper ES, Jilani T, Quinlan PR, et al., OCEANIC Study Investigators. Study protocol for a multicentre longitudinal mixed methods study to explore the Outcomes of ChildrEn and fAmilies in the first year after paediatric Intensive Care: the OCEANIC study. BMJ Open 2020;10:e038974.
  133. Menzies JC. Thesis: Designing and Conducting Feasible and Acceptable Pharmacokinetic Research in Critically Ill Children: A Mixed Methods Study. Birmingham: University of Birmingham; 2018.
  134. South A, Hanley B, Gafos M, Cromarty B, Stephens R, Sturgeon K, et al. Models and impact of patient and public involvement in studies carried out by the Medical Research Council Clinical Trials Unit at University College London: findings from ten case studies. Trials 2016;17:376.27473060
  135. NIHR. Reward and recognition for public contributors – a guide to the payment of fees and expenses. National Institute for Health Research (NIHR) 2018. URL: www.nihr.ac.uk/documents/reward-and-recognition-for-public-contributors-a-guide-to-the-payment-of-fees-and-expenses/12248 (accessed 16 February 2022).
  136. University of Oxford. Guide for Researchers Working with Patient and Public Involvement (PPI) Contributors. 6th edn. Oxford: University of Oxford Nuffield Department of Primary Care Health Sciences; 2017.
  137. NIHR. Public reviewing with the National Institute for Health Research (NIHR) 2022. URL: www.invo.org.uk/resource-centre/learning-and-development/public-reviewing-with-the-national-institute-for-health-research-nihr/ (accessed 28 February 2022).
  138. Buck D, Gamble, C, Dudley L, Preston J, Hanley B, Williamson P, Young B, EPIC Patient Advisory Group and EPIC Patient Advisory Group. From plans to actions in patient and public involvement: qualitative study of documented plans and the accounts of researchers and patients sampled from a cohort of clinical trials. BMJ Open 2014;4:e006400.
  139. Staley K. ‘Is it worth doing? Measuring the impact of patient and public involvement in research’. Rese Invol Engagem 2015;1:6.
  140. NIHR. Improving inclusion of under-served groups in clinical research: guidance from the National Institute for Health Research (NIHR) INCLUDE project UK. NIHR 2020. URL: www.nihr.ac.uk/documents/improving-inclusion-of-under-served-groups-in-clinical-research-guidance-from-include-project/25435 (accessed 28 March 2022).
  141. Kanthimathinathan H, Scholefield BR. Dilemmas in undertaking research in paediatric intensive care. Arch Dis Child 2014;99:1043–9.24919710
  142. Choong K, Dufett M, Cook DJ, Randolph AG. The impact of clinical trials conducted by research networks in pediatric critical care. Pediatr Crit Care Med J Soc Crit Care Med World Fed Pediatr Intensive Crit Care Soc 2016;17:837–44.
  143. Drury NE, Patel AJ, Oswald NK, Chong CR, Stickley J, Baron DJ, Jones TJ. Randomized controlled trials in children’s heart surgery in the 21st century: a systematic review. Eur J Cardiothorac Surg 2018;53:724–31.29186478
← Discussion and conclusionsAcknowledgements →

Attribution. Barnaby R Scholefield; Julie C Menzies; Jennifer McAnuff; Jacqueline Y Thompson; Joseph C Manning; Richard G Feltbower et al. (2023). Implementing early rehabilitation and mobilisation for children in UK paediatric intensive care units: the PERMIT feasibility study. National Institute for Health and Care Research. Copyright © 2023 Scholefield et al. Licensed under CC BY 4.0. NCBI Bookshelf NBK597819. CC BY 4.0. Original source ↗. Text reproduced from the Bookshelf XML without changing wording; figures, images and supplements are not reproduced.

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