CRediT contribution statement
Shankar Kumar (https://orcid.org/0000-0002-5945-8791): Conceptualisation, Data curation, Investigation, Methodology, Visualisation, Writing – original draft, Writing – editing and reviewing.
Andrew Plumb (https://orcid.org/0000-0003-1322-5113): Conceptualisation, Data curation, Funding acquisition, Investigation, Methodology, Supervision, Writing – editing and reviewing.
Sue Mallett (https://orcid.org/0000-0002-0596-8200): Conceptualisation, Formal analysis, Funding acquisition, Methodology, Methodology, Supervision, Writing – editing and reviewing.
Caroline Clarke (https://orcid.org/0000-0002-4676-1257): Formal analysis, Methodology, Supervision, Visualisation, Writing – original draft, Writing – editing and reviewing.
Tom Parry (https://orcid.org/0000-0001-8855-0661): Formal analysis, Visualisation, Writing – editing and reviewing.
Jing Yi Jessica Weng (https://orcid.org/0000-0002-2875-4029): Formal analysis, Visualisation, Writing – original draft, Writing – editing and reviewing.
Gauraang Bhatnagar (https://orcid.org/0000-0001-6607-1117): Data curation, Investigation, Writing – editing and reviewing.
Stuart Bloom (https://orcid.org/0009-0002-5027-0765): Conceptualisation, Data curation, Funding acquisition, Investigation, Writing – editing and reviewing.
John Hamlin (https://orcid.org/0000-0001-8080-1358): Conceptualisation, Data curation, Funding acquisition, Investigation, Writing – editing and reviewing.
Ailsa Hart (https://orcid.org/0000-0002-7141-6076): Conceptualisation, Data curation, Funding acquisition, Investigation, Methodology, Writing – editing and reviewing.
Simon Travis (https://orcid.org/0000-0002-2690-4361): Conceptualisation, Data curation, Funding acquisition, Investigation, Methodology, Writing – editing and reviewing.
Roser Vega (https://orcid.org/0000-0002-0116-7211): Data curation, Investigation, Writing – editing and reviewing.
Maira Hameed (https://orcid.org/0000-0002-6290-5695): Data curation, Investigation, Writing – editing and reviewing.
Anisha Bhagwanani (https://orcid.org/0000-0001-6112-5171): Data curation, Investigation, Writing – editing and reviewing.
Rebecca Greenhalgh (https://orcid.org/0009-0001-5345-3535): Data curation, Investigation, Writing – editing and reviewing.
Emma Helbren (https://orcid.org/0000-0001-9524-0055): Data curation, Investigation, Writing – editing and reviewing.
James A Stephenson (https://orcid.org/0000-0001-5649-6322): Data curation, Investigation, Writing – editing and reviewing.
Ian Zealley (https://orcid.org/0000-0001-8776-9071): Data curation, Investigation, Writing – editing and reviewing.
Vivienne Eze (https://orcid.org/0000-0001-8298-9614): Data curation, Investigation, Writing – editing and reviewing.
James Franklin (https://orcid.org/0000-0002-0316-3177): Data curation, Investigation, Writing – editing and reviewing.
Alison Corr (https://orcid.org/0000-0002-6902-7362): Data curation, Investigation, Writing – editing and reviewing.
Arun Gupta (https://orcid.org/0000-0003-0311-4284): Data curation, Investigation, Writing – editing and reviewing.
Elizabeth Isaac (https://orcid.org/0000-0002-4928-0870): Data curation, Investigation, Project administration, Writing – editing and reviewing.
Damian Tolan (https://orcid.org/0000-0001-9895-9874): Data curation, Investigation, Writing – editing and reviewing.
William Hogg (https://orcid.org/0009-0007-6548-0892): Data curation, Investigation, Writing – editing and reviewing.
Antony Higginson (https://orcid.org/0000-0002-9690-5394): Data curation, Investigation, Writing – editing and reviewing.
Michela Cicchetti (https://orcid.org/0009-0006-7206-3643): Data curation, Investigation, Writing – editing and reviewing.
Sunita Gupta (https://orcid.org/0000-0001-8657-7932): Data curation, Investigation, Writing – editing and reviewing.
Miguel Serran (https://orcid.org/0009-0008-8758-3291): Data curation, Investigation, Writing – editing and reviewing.
Tim Raine (https://orcid.org/0000-0002-5855-9873): Data curation, Investigation, Methodology, Writing – editing and reviewing.
Mohamed Ahmed (https://orcid.org/0000-0001-9329-6063): Data curation, Investigation, Writing – editing and reviewing.
Biljana Brezina (https://orcid.org/0000-0001-5060-5604): Data curation, Investigation, Writing – editing and reviewing.
Ilse Patterson (https://orcid.org/0000-0002-4092-4553): Data curation, Writing – editing and reviewing.
Louise Lee (https://orcid.org/0000-0002-6200-3069): Data curation, Investigation, Writing – editing and reviewing.
Richard Pollok (https://orcid.org/0000-0001-6452-6763): Data curation, Investigation, Writing – editing and reviewing.
Jaymin Patel (https://orcid.org/0009-0009-2886-8286): Data curation, Investigation, Writing – editing and reviewing.
Abigail Seward (https://orcid.org/0009-0004-6685-185X): Data curation, Writing – editing and reviewing.
Samantha Baillie (https://orcid.org/0000-0003-3280-0347): Data curation, Investigation, Writing – editing and reviewing.
Kashfia Chowdary (https://orcid.org/0000-0002-8185-5152): Data curation, Investigation, Writing – editing and reviewing.
Sue Philpott (https://orcid.org/0000-0002-1019-5871): Data curation, Investigation, Project administration, Writing – editing and reviewing.
Anvi Wadke (https://orcid.org/0009-0009-6846-1034): Data curation, Investigation, Project administration, Writing – editing and reviewing.
Steve Halligan (https://orcid.org/0000-0003-0632-5108): Conceptualisation, Data curation, Funding acquisition, Investigation, Methodology, Supervision, Writing – original draft, Writing – editing and reviewing.
Stuart A Taylor (https://orcid.org/0000-0002-6765-8806): Conceptualisation, Data curation, Funding acquisition, Investigation, Methodology, Supervision, Writing – original draft, Writing – editing and reviewing.
Acknowledgements
This project was supported by researchers at the NIHR UCLH Biomedical Research Centre. Thank you to Valentina Raspa and Kadri Sudarshan.
Clinical Trial Unit
Comprehensive Clinical Trials Unit at UCL
We are grateful to Nicola Gibbons (Radiographer), Bindiya Kerai (Research Radiographer), Mary Lucas (Research Coordinator), Jean Wilson (Research Nurse), Joanne Wormleighton (Research Radiographer), Katherine Coll (Research and Development Administrator), Ilan Jacobs (patient representative), Teresita Beeston (research nurse), Doris Quartey (research nurse), Claire Ward (research practitioner), Valentina Raspa (research nurse), Kadri Sudarshan (consultant gastroenterologist), Jacqueline Patterson (consultant gastroenterologist).
Trial Steering Committee
Vicky Goh, James Lindsay and Andrea Marshall.
Patient data statement
This work uses data provided by patients and collected by the NHS as part of their care and support. Using patient data are vital to improve health and care for everyone. There is huge potential to make better use of information from people’s patient records to understand more about disease, develop new treatments, monitor safety and plan NHS services. Patient data should be kept safe and secure to protect everyone’s privacy, and it’s important that there are safeguards to make sure that they are stored and used responsibly. Everyone should be able to find out about how patient data are used. #datasaveslives You can find out more about the background to this citation here: https://understandingpatientdata.org.uk/data-citation
Data-sharing statement
All data requests should be submitted to the corresponding author for consideration. Access to available anonymised data may be granted following review.
Ethics statement
The METRIC-EF study achieved NHS Research Ethics Committee (NHS REC), London – Hampstead Research Ethics Committee approval on 26 October 2018 (IRAS 217422) and was conducted in accordance with the principles of good clinical practice. UCL’s CCTU supervised the study.
Information governance statement
University College London is committed to handling all personal information in line with the UK Data Protection Act (2018) and the General Data Protection Regulation (EU GDPR) 2016/679. Under the Data Protection legislation, UCL is the Data Controller, and you can find out more about how we handle personal data, including how to exercise your individual rights and the contact details for our Data Protection Officer here www.ucl.ac.uk/data-protection/data-protection-0.
Disclosure of interests
Full disclosure of interests: Completed ICMJE forms for all authors, including all related interests, are available in the toolkit on the NIHR Journals Library report publication page at https://doi.org/10.3310/THSN9956.
Primary conflicts of interest: Andrew Plumb – NIHR HTA including grant support for the conduct of this study, grants from NIHR Fellowships programme; and personal fees from Acelity, Actavis, Dr Falk, Janssen-Cilag, and Takeda.
Sue Mallett – Grant support from the NIHR HTA for the present manuscript.
Stuart Bloom – Grant support from the NIHR HTA for the present manuscript.
John Hamlin – Grant support from the NIHR HTA for the present manuscript.
Ailsa Hart – Grant support from the NIHR HTA for the present manuscript.
Simon Travis – Grants/Research Support: Grant support from the NIHR HTA for the present manuscript, AbbVie, Buhlmann, Celgene, ECCO, Helmsley Trust, IOIBD, Janssen, Lilly, NIHR HTA including for the present manuscript. Pfizer, Takeda, UCB, UKIERI, Vifor, and Norman Collisson Foundation. Consulting Fees: Abacus; AbbVie; Actial; ai4gi; Alcimed; Allergan; Amgen; Apexian; Aptel; Arena; Asahi; Aspen; Astellas; Atlantic; AstraZeneca; Barco; Biocare; Biogen; BLPharma; Boehringer Ingelheim; BMS; Buhlmann; Calcico; Celgene; Cellerix; Cerimon; ChemoCentryx; Chiesi; CisBio; ComCast; Coronado; Cosmo; Ducentis; Dynavax; Elan; Enterome; EQrX; Equillium; Falk; Ferring; FPRT Bio; Galapagos; Genentech/Roche; Genzyme; Gilead; Glenmark; Grunenthal; GSK; GW Pharmaceuticals; Immunocore; Immunometabolism; Indigo; Janssen; Lexicon; Lilly; Medarex; Medtrix; Merck; Merrimack; Mestag; Millenium; Neovacs; Novartis; Novo Nordisk; NPS-Nycomed; Ocera; Optima; Origin; Otsuka; Palau; Pentax; Pfizer; Pharmaventure; Phesi; Phillips; P&G; Pronota; Protagonist; Proximagen; Resolute; Robarts; Sandoz; Santarus; Satisfai; Sensyne Health; Shire; SigmoidPharma; Sorriso; Souffinez; Syndermix; Synthon; Takeda; Theravance; Tigenix; Tillotts; Topivert; Trino Therapeutics with Wellcome Trust; TxCell; UCB Pharma; Vertex; VHsquared; Vifor; Warner Chilcott and Zeria
Speaker fees: AbbVie, Amgen, Biogen, Falk; Ferring, Janssen, Pfizer, Shire, Takeda, UCB.
No stocks or shares options.
Ian Zealley – Grant support from the NIHR HTA for the present manuscript.
Tim Raine – Grant: Abbvie
Personal Fees: Abbvie, Arena, Aslan, AstraZeneca, Boehringer-Ingelheim, BMS, Celgene, Ferring, Galapagos, Gilead, GSK, Heptares, LabGenius, Janssen, Mylan, MSD, Novartis, Pfizer, Roche, Sandoz, Takeda and UCB
Steve Halligan – Grant support from the NIHR HTA for the present manuscript. NIHR emeritus senior investigator
Stuart A Taylor – Grant support from the NIHR HTA for the present manuscript. Personal fees from Alimentiv, shareholding in Motilent and grants from the NIHR. Consultant for AstraZeneca. Board member EME programme committee. NIHR emeritus senior investigator.
Disclaimer
Every effort has been made to obtain the necessary permissions for reproduction, to credit original sources appropriately and to respect copyright requirements. However, despite our diligence, we acknowledge the possibility of unintentional omissions or errors and we welcome notifications of any concerns regarding copyright or permissions.
Publications
Kumar S, Plumb A, Mallett S, Bhatnagar G, Bloom S, Clarke CS, et al. METRIC-EF: magnetic resonance enterography to predict disabling disease in newly diagnosed Crohn’s disease-protocol for a multicentre, non-randomised, single-arm, prospective study. BMJ Open 2022;12:e067265. https://doi.org/10.1136/bmjopen-2022-067265
Taylor SA, Kumar S, Parry T, Mallett S, Travis S, Raine T, et al. Magnetic resonance enterography to predict subsequent disabling Crohn’s disease in newly diagnosed patients (METRIC-EF)-multivariable prediction model, multicentre diagnostic inception cohort. Eur Radiol 2025;35(11):7333–45. https://doi.org/10.1007/s00330-025-11636-8
Disclaimers
This article presents independent research funded by the National Institute for Health and Care Research (NIHR). The views and opinions expressed by authors in this publication are those of the authors and do not necessarily reflect those of the NHS, the NIHR, the HTA programme or the Department of Health and Social Care. If there are verbatim quotations included in this publication the views and opinions expressed by the interviewees are those of the interviewees and do not necessarily reflect those of the authors, those of the NHS, the NIHR, the HTA programme or the Department of Health and Social Care.