Parts of this chapter have been reproduced with permission from Kumar et al.1 This is an Open Access article distributed in accordance with the terms of the Creative Commons Attribution (CC BY 4.0) licence, which permits others to distribute, remix, adapt and build upon this work, for commercial use, provided the original work is properly cited. See: https://creativecommons.org/licenses/by/4.0/. The text below includes minor additions and formatting changes to the original text.
Primary objective
- To improve prediction of disabling CD within 5 years of diagnosis by developing and internally evaluating a multivariable prediction model comprising both existing standard predictors and those based on MRE.
Secondary objectives
- To improve the prediction of disabling CD within 5 years, defined by the Montreal and Liège behaviour criteria, by developing and internally evaluating a multivariable prediction model comprising clinical predictors and adding MRE scores.
- To identify specific combinations of individual MRE findings that best predict disabling CD within 5 years of diagnosis.
- To estimate the healthcare costs incurred within 5 years of a new diagnosis of CD and to explore patient, imaging and disease characteristics driving higher health economic costs.
- Assuming promising predictive potential, to then generate a research design for a subsequent prospective study to externally evaluate our MRE-based prediction model if appropriate.