The CARE pilot RCT recruited successfully, provided insights into the barriers to informed consent and recruitment, tested interventions to address these barriers and generated a variety of estimates to inform the design of a definitive RCT. It seems that a definitive RCT would be feasible if the large number of international clinical and patient communities that expressed interest in a definitive RCT remain in equipoise after the dissemination of the CARE pilot RCT results, although extensive international involvement and shared support from multiple funding agencies will be needed.
Medical management and intervention (using neurosurgical resection or stereotactic radiosurgery) versus medical management alone for symptomatic brain cavernoma: the CARE pilot RCT · Conclusions
Conclusions
Attribution. Rustam Al-Shahi Salman; Neil Kitchen; Laura Forsyth; Vijeya Ganesan; Peter S Hall; Kirsty Harkness et al. (2025). Medical management and intervention (using neurosurgical resection or stereotactic radiosurgery) versus medical management alone for symptomatic brain cavernoma: the CARE pilot RCT. National Institute for Health and Care Research. Copyright © 2025 Al-Shahi Salman et al. Licensed under CC BY 4.0. NCBI Bookshelf NBK617151. CC BY 4.0. Original source ↗. Text reproduced from the Bookshelf XML without changing wording; figures, images and supplements are not reproduced.