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Nicotine preloading for smoking cessation: the Preloading RCT · References

References

CC BY 4.0 · NIHR Journals Library · approximately 11 min read

  1. Hughes JR, Keely J, Naud S. Shape of the relapse curve and long-term abstinence among untreated smokers. Addiction 2004;99:29–38. 10.1111/j.1360-0443.2004.00540.x14678060
  2. West R, Shiffman S. Effect of oral nicotine dosing forms on cigarette withdrawal symptoms and craving: a systematic review. Psychopharmacology 2001;155:115–22. 10.1007/s00213010071211400998
  3. Shiffman S, Shadel WG, Niaura R, Khayrallah MA, Jorenby DE, Ryan CF, Ferguson CL. Efficacy of acute administration of nicotine gum in relief of cue-provoked cigarette craving. Psychopharmacology 2003;166:343–50. 10.1007/s00213-002-1338-112601502
  4. Hughes JR. Effects of abstinence from tobacco: valid symptoms and time course. Nicotine Tob Res 2007;9:315–27. 10.1080/1462220070118891917365764
  5. Hartmann-Boyce J, Aveyard P. Drugs for smoking cessation. BMJ 2016;352:i571. 10.1136/bmj.i57126907501
  6. Cahill K, Stevens S, Perera R, Lancaster T. Pharmacological interventions for smoking cessation: an overview and network meta-analysis. Cochrane Database Syst Rev 2013;10:CD009329. 10.1002/14651858.CD009329.pub2
  7. West R, Baker C, Cappelleri J, Bushmakin A. Effect of varenicline and bupropion SR on craving, nicotine withdrawal symptoms, and rewarding effects of smoking during a quit attempt. Psychopharmacology (Berl) 2008;197:371–7. 10.1007/s00213-007-1041-318084743
  8. Fagerström KO, Hughes JR. Nicotine concentrations with concurrent use of cigarettes and nicotine replacement: a review. Nicotine Tob Res 2002;4(Suppl. 2):73–9. 10.1080/1462220021000032753
  9. West R. Defining and Assessing Nicotine Dependence in Humans. In Corrigall WA, editor. Understanding Nicotine and Tobacco Addiction. Chichester: John Wiley & Sons, Ltd; 2006. pp. 36–63. 10.1002/9780470029237.ch4
  10. Stead LF, Perera R, Bullen C, Mant D, Lancaster T. Nicotine replacement therapy for smoking cessation. Cochrane Database Syst Rev 2008;1:CD000146. 10.1002/14651858.CD000146.pub3
  11. Shiffman S, Sweeney CT, Ferguson SG, Sembower MA, Gitchell JG. Relationship between adherence to daily nicotine patch use and treatment efficacy: secondary analysis of a 10-week randomized, double-blind, placebo-controlled clinical trial simulating over-the-counter use in adult smokers. Clin Ther 2008;30:1852–8. 10.1016/j.clinthera.2008.09.01619014840
  12. Lindson N, Aveyard P. An updated meta-analysis of nicotine preloading for smoking cessation: investigating mediators of the effect. Psychopharmacology (Berl) 2011;214:579–92. 10.1007/s00213-010-2069-321060996
  13. West R, Brown J. Theory of Addiction. Chichester: John Wiley & Sons, Ltd; 2013. 10.1002/9781118484890
  14. Foulds J, Hughes J, Hyland A, Le Houezec J, McNeill A, Melvin C, et al. Barriers to Use of FDA-approved Smoking Cessation Medications: Implications for Policy Action. Madison, WI: Society for Research on Nicotine and Tobacco; 2009.
  15. Shiffman S. Use of more nicotine lozenges leads to better success in quitting smoking. Addiction 2007;102:809–14. 10.1111/j.1360-0443.2007.01791.x17493108
  16. Gwaltney CJ, Metrik J, Kahler CW, Shiffman S. Self-efficacy and smoking cessation: a meta-analysis. Psychol Addict Behav 2009;23:56–66. 10.1037/a001352919290690
  17. Lindson-Hawley N, Banting M, West R, Michie S, Shinkins B, Aveyard P. Gradual versus abrupt smoking cessation: a randomized, controlled noninferiority trial. Ann Intern Med 2016;164:585–92. 10.7326/M14-280526975007
  18. Hajek P, Stead LF. Aversive smoking for smoking cessation. Cochrane Database Syst Rev 2001;3:CD000546. 10.1002/14651858.CD000546.pub2
  19. Doll R, Peto R, Boreham J, Sutherland I. Mortality in relation to smoking: 50 years’ observations on male British doctors. BMJ 2004;328:1519. 10.1136/bmj.38142.554479.AE15213107
  20. West R. The clinical significance of ‘small’ effects of smoking cessation treatments. Addiction 2007;102:506–9. 10.1111/j.1360-0443.2007.01750.x17362283
  21. Hajek P, McRobbie HJ, Myers KE, Stapleton J, Dhanji AR. Use of varenicline for 4 weeks before quitting smoking: decrease in ad lib smoking and increase in smoking cessation rates. Arch Intern Med 2011;171:770–7. 10.1001/archinternmed.2011.13821518946
  22. Rose JE, Behm FM, Westman EC, Kukovich P. Precessation treatment with nicotine skin patch facilitates smoking cessation. Nicotine Tob Res 2006;8:89–101. 10.1080/1462220050043186616497603
  23. Rose JE, Herskovic JE, Behm FM, Westman EC. Precessation treatment with nicotine patch significantly increases abstinence rates relative to conventional treatment. Nicotine Tob Res 2009;11:1067–75. 10.1093/ntr/ntp10319567826
  24. Rose JE, Behm FM, Drgon T, Johnson C, Uhl GR. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. Mol Med 2010;16:247. 10.2119/molmed.2009.0015920379614
  25. Lindson-Hawley N, Shinkins B, West R, Michie S, Aveyard P. Does cigarette reduction while using nicotine replacement therapy prior to a quit attempt predict abstinence following quit date? Addiction 2016;111:1275–82. 10.1111/add.1333026990374
  26. Lindson-Hawley N, Coleman T, Docherty G, Hajek P, Lewis S, Lycett D, et al. Nicotine patch preloading for smoking cessation (the preloading trial): study protocol for a randomized controlled trial. Trials 2014;15:296. 10.1186/1745-6215-15-29625052334
  27. Flaxman J. Quitting smoking now or later: gradual, abrupt, immediate, and delayed quitting. Behav Ther 1978;9:260–70. 10.1016/S0005-7894(78)80111-7
  28. National Institute for Health and Care Excellence (NICE). Guidance on Smoking Cessation. London: NICE; 2008.
  29. Hajek P. Withdrawal-oriented therapy for smokers. Br J Addict 1989;84:591–8. 10.1111/j.1360-0443.1989.tb03474.x2752191
  30. West R, Hajek P, Stead L, Stapleton J. Outcome criteria in smoking cessation trials: proposal for a common standard. Addiction 2005;100:299–303. 10.1111/j.1360-0443.2004.00995.x15733243
  31. Medical Dictionary for Regulatory Activities. Welcome to MedDRA. URL: www.meddra.org (accessed 23 January 2018).
  32. Marteau TM, Aveyard P, Munafò MR, Prevost AT, Hollands GJ, Armstrong D, et al. Effect on adherence to nicotine replacement therapy of informing smokers their dose is determined by their genotype: a randomised controlled trial. PLOS ONE 2012;7:e35249. 10.1371/journal.pone.003524922509402
  33. Aveyard P, Johnson C, Fillingham S, Parsons A, Murphy M. Nortriptyline plus nicotine replacement versus placebo plus nicotine replacement for smoking cessation: pragmatic randomised controlled trial. BMJ 2008;336:1223–7. 10.1136/bmj.39545.852616.BE18441375
  34. Fidler J, Ferguson SG, Brown J, Stapleton J, West R. How does rate of smoking cessation vary by age, gender and social grade? Findings from a population survey in England. Addiction 2013;108:1680–5. 10.1111/add.1224123668684
  35. West R, Ussher M. Is the ten-item Questionnaire of Smoking Urges (QSU-brief) more sensitive to abstinence than shorter craving measures? Psychopharmacology 2010;208:427–32. 10.1007/s00213-009-1742-x20033133
  36. Aveyard P, Brown K, Saunders C, Alexander A, Johnstone E, Munafò MR, Murphy M. Weekly versus basic smoking cessation support in primary care: a randomised controlled trial. Thorax 2007;62:898–903. 10.1136/thx.2006.07183717483139
  37. Loudon K, Treweek S, Sullivan F, Donnan P, Thorpe KE, Zwarenstein M. The PRECIS-2 tool: designing trials that are fit for purpose. BMJ 2015;350:h2147. 10.1136/bmj.h214725956159
  38. PRagmatic Explanatory Continuum Indicator Summary (PRECIS)-2. PRECIS-2. URL: http://precis-2.org (accessed 23 January 2018).
  39. The Preloading Investigators. Effects on abstinence of nicotine patch treatment before quitting smoking: parallel, two arm, pragmatic randomised trial. BMJ 2018;361:k2164. 10.1136/bmj.k216429899061
  40. The Organisation for Economic Co-operation and Development (OECD). Education at a Glance 2014. France: OECD; 2014.
  41. Kenny DA. Mediation. 2016. URL: http://davidakenny.net/cm/mediate.htm (accessed 3 January 2017).
  42. Cappelleri JC, Bushmakin AG, Baker CL, Merikle E, Olufade AO, Gilbert DG. Confirmatory factor analyses and reliability of the modified cigarette evaluation questionnaire. Addict Behav 2007;32:912–23. 10.1016/j.addbeh.2006.06.02816875787
  43. West R, Hajek P. Evaluation of the mood and physical symptoms scale (MPSS) to assess cigarette withdrawal. Psychopharmacology (Berl) 2004;177:195–9. 10.1007/s00213-004-1923-615179542
  44. Shiffman S, Waters AJ, Hickcox M. The Nicotine Dependence Syndrome Scale: a multidimensional measure of nicotine dependence. Nicotine Tob Res 2004;6:327–48. 10.1080/146222004200020248115203807
  45. Heatherton TF, Kozlowski LT, Frecker RC, Fagerström KO. The Fagerström Test for Nicotine Dependence: a revision of the Fagerström Tolerance Questionnaire. Br J Addict 1991;86:1119–27. 10.1111/j.1360-0443.1991.tb01879.x1932883
  46. Shiffman S, West R, Gilbert D, SRNT Work Group on the Assessment of Craving and Withdrawal in Clinical Trials. Recommendation for the assessment of tobacco craving and withdrawal in smoking cessation trials. Nicotine Tob Res 2004;6:599–614. 10.1080/1462220041000173406715370156
  47. Lindson N, Aveyard P, Ingram JT, Inglis J, Beach J, West R, Michie S. Rapid reduction versus abrupt quitting for smokers who want to stop soon: a randomised controlled non-inferiority trial. Trials 2009;10:69. 10.1186/1745-6215-10-6919682359
  48. Aveyard P. The place of varenicline in smoking cessation treatment. Thorax 2008;63:666–8. 10.1136/thx.2008.09608118663065
  49. Parrott S, Godfrey C, Raw M, West R, McNeill A. Guidance for commissioners on the cost effectiveness of smoking cessation interventions. Health Educational Authority. Thorax 1998;53:S1–38.
  50. US Department of Health and Human Services. The Health Consequences of Smoking – 50 Years of Progress: A Report of the Surgeon General. Atlanta, GA: US Department of Health and Human Services, Centers for Disease Control and Prevention, National Center for Chronic Disease Prevention and Health Promotion, Office on Smoking and Health; 2014.
  51. National Institute for Health and Care Excellence (NICE). Guide to the Methods of Technology Appraisal 2013. London: NICE; 2013.
  52. National Institute for Health and Care Excellence (NICE). Smoking Cessation Services Costing Report – Implementing NICE Guidance. London: NICE; 2008.
  53. Prescribing and Medicines Team. Prescription Cost Analysis, England 2015. Leeds: NHS Digital (formerly the Health and Social Care Information Centre); 2016.
  54. Curtis L, Burns A. Unit Costs of Health and Social Care 2015. Canterbury: Personal Social Services Research Unit, University of Kent; 2015.
  55. Parrott S, Godfrey C, Kind P. Cost-effectiveness of Brief Intervention and Referral for Smoking Cessation. York: Centre for Health Economics, University of York; 2006.
  56. Department of Health and Social Care. Reference Costs 2014–15. London: DHSC; 2015.
  57. Rubin DB. Statistical matching using file concatenation with adjusted weights and multiple imputations. J Bus Econ Stat 1986;4:87–94. 10.2307/1391390
  58. Efron B, Tibshirani R. An Introduction to the Bootstrap. New York, NY: Chapman & Hall; 1993. 10.1007/978-1-4899-4541-9
  59. Chaudhary MA, Stearns SC. Estimating confidence intervals for cost-effectiveness ratios: an example from a randomized trial. Stat Med 1996;15:1447–58. 10.1002/(SICI)1097-0258(19960715)15:13<1447::AID-SIM267>3.0.CO;2-V8841654
  60. Willan AR, O’Brien BJ. Confidence intervals for cost-effectiveness ratios: an application of Fieller’s theorem. Health Econ 1996;5:297–305. 10.1002/(SICI)1099-1050(199607)5:4<297::AID-HEC216>3.0.CO;2-T8880166
  61. Severens JL, De Boo TM, Konst EM. Uncertainty of incremental cost-effectiveness ratios. A comparison of Fieller and bootstrap confidence intervals. Int J Technol Assess Health Care 1999;15:608–14.10874387
  62. Fenwick E, Claxton K, Sculpher M. Representing uncertainty: the role of cost-effectiveness acceptability curves. Health Econ 2001;10:779–87. 10.1002/hec.63511747057
  63. Design & Print Solutions. Business Stationery. 2017. URL: www.york.ac.uk/media/design-and-print/print-solutions/pricing/price_list.pdf (accessed 14 February 2017).
  64. White IR, Royston P, Wood AM. Multiple imputation using chained equations: issues and guidance for practice. Stat Med 2011;30:377–99. 10.1002/sim.406721225900
  65. Lifestyles Statistics Team. Statistics on NHS Stop Smoking Services in England April 2014 to March 2015. Leeds: NHS Digital; 2015.
  66. Pokhrel S, Evers S, Leidl R, Trapero-Bertran M, Kalo Z, Vries H, et al. EQUIPT: protocol of a comparative effectiveness research study evaluating cross-context transferability of economic evidence on tobacco control. BMJ Open 2014;4:e006945-e. 10.1136/bmjopen-2014-006945
  67. Coyle K, Coyle D, Lester-George A, West R, Nemeth B, Hiligsmann M, et al. Development and application of an economic model (EQUIPTMOD) to assess the impact of smoking cessation [published online ahead of print August 18 2017]. Addiction 2017. 10.1111/add.14001
  68. Etter JF, Stapleton JA. Nicotine replacement therapy for long-term smoking cessation: a meta-analysis. Tob Control 2006;15:280–5. 10.1136/tc.2005.01548716885576
  69. West R. Background Smoking Cessation Rates in England. London: Smoking in England; 2006.
  70. Office for National Statistics (ONS). National Life Tables, United Kingdom: 2012–2014. Newport: ONS; 2014.
  71. Public Health England. Local Tobacco Control Profiles for England. 2014.
  72. Thun MJ, Apicella LF, Henley SJ. Smoking vs. other risk factors as the cause of smoking-attributable deaths: confounding in the courtroom. JAMA 2000;284:706–12. 10.1001/jama.284.6.70610927778
  73. US Department of Health and Human Services. The Health Consequences of Smoking: A Report of the Surgeon General. Atlanta, GA: US Department of Health and Human Services, Centers for Disease Control and Prevention, National Centre for Chronic Disease Prevention and Health Promotion, Office on Smoking and Health; 2004.
  74. Townsend N, Wickramasinghe K, Bhatnagar P, Smolina K, Nichols M, Leal J, et al. Coronary Heart Disease Statistics: A Compendium of Health Statistics. 2012 Edition. London: British Heart Foundation; 2012.
  75. Association of Public Health Observatories (APHO). Modelled Estimate of Prevalence of COPD in England. APHO: 2011.
  76. NHS Digital. Health Survey for England – 2013. Leeds: NHS Digital; 2013.
  77. Maddams J, Brewster D, Gavin A, Steward J, Elliott J, Utley M, Møller H. Cancer prevalence in the United Kingdom: estimates for 2008. Br J Cancer 2009;101:541–7. 10.1038/sj.bjc.660514819568236
  78. Thun MJ, Carter BD, Feskanich D, Freedman ND, Prentice R, Lopez AD, et al. 50-year trends in smoking-related mortality in the United States. N Engl J Med 2013;368:351–64. 10.1056/NEJMsa121112723343064
  79. Britton M. The burden of COPD in the UK: results from the Confronting COPD survey. Respir Med 2003;97(Suppl. C):71–9. 10.1016/S0954-6111(03)80027-612556014
  80. McMurray J, Hart W, Rhodes G. An evaluation of the cost of health failure to the National Health Service in the UK. J Med Econ 1993;6:99–110.
  81. Sanderson H, Spiro S. Cancer of the Lung. In Stevens A, Raftery J, Mant J, Simpson S, editors. Health Care Needs Assessment: The Epidemiologically Based Needs Assessment Reviews. 2nd edn. Abingdon: Radcliffe Publishing; 2004. pp. 503–48.
  82. Simpson EL, Stevenson MD, Scope A, Poku A, Minton J, Evans P. Echocardiography in newly diagnosed atrial fibrillation patients: a systematic review and economic evaluation. Health Technol Assess 2013;17(36). 10.3310/hta17360
  83. Curtis L, Burns A. Unit Costs of Health and Social Care 2016. Canterbury: Personal Social Services Research Unit, University of Kent; 2016.
  84. Sullivan PW, Slejko JF, Sculpher MJ, Ghushchyan V. Catalogue of EQ-5D scores for the United Kingdom. Med Decis Making 2011;31:800–4. 10.1177/0272989X1140103121422468
  85. Vogl M, Wenig CM, Leidl R, Pokhrel S. Smoking and health-related quality of life in English general population: implications for economic evaluations. BMC Public Health 2012;12:203. 10.1186/1471-2458-12-20322429454
  86. Brazier J, Czoski-Murray C, Roberts J, Brown M, Symonds T, Kelleher C. Estimation of a preference-based index from a condition specific measure: the King’s Health Questionnaire. Med Decis Making 2008;28:113–26. 10.1177/0272989X0730182017641139
  87. National Institute for Health and Care Excellence. Discounting of Health Benefits in Special Circumstances. URL: www.nice.org.uk/guidance/ta235/resources/osteosarcoma-mifamurtide-discounting-of-health-benefits-in-special-circumstances2 (accessed 23 January 2018).
  88. Briggs AH. Handling uncertainty in cost-effectiveness models. PharmacoEconomics 2000;17:479–500. 10.2165/00019053-200017050-0000610977389
  89. UK Centre for Tobacco and Alcohol Studies. UKCTAS. URL: www.ukctas.ac.uk (accessed 23 January 2018).
  90. Consolidated Standards of Reporting Trials. Welcome to the CONSORT Website. URL: www.consort-statement.org (accessed 23 January 2018).
  91. Hughes JR, Keely JP, Fagerstrom KO, Callas PW. Intentions to quit smoking change over short periods of time. Addict Behav 2005;30:653–62. 10.1016/j.addbeh.2004.08.01115833571
  92. Borland R, Partos TR, Yong H-H, Cummings KM, Hyland A. How much unsuccessful quitting activity is going on among adult smokers? Data from the International Tobacco Control 4-Country cohort survey. Addiction 2012;107:673–82. 10.1111/j.1360-0443.2011.03685.x21992709
  93. Bauld L, Hiscock R, Dobbie F, Aveyard P, Coleman T, Leonardi-Bee J, et al. English Stop-Smoking Services: one-year outcomes. Int J Environ Res Public Health 2016;13:E1175. 10.3390/ijerph1312117527886140
  94. Anthenelli RM, Benowitz NL, West R, St Aubin L, McRae T, Lawrence D, et al. Neuropsychiatric safety and efficacy of varenicline, bupropion, and nicotine patch in smokers with and without psychiatric disorders (EAGLES): a double-blind, randomised, placebo-controlled clinical trial. Lancet 2016;387:2507–20. 10.1016/S0140-6736(16)30272-027116918
  95. Benowitz NL, Zevin S, Jacob P. Suppression of nicotine intake during ad libitum cigarette smoking by high-dose transdermal nicotine. J Pharmacol Exp Ther 1998;287:958–62.9864279
  96. Hawk LW, Ashare RL, Lohnes SF, Schlienz NJ, Rhodes JD, Tiffany ST, et al. The effects of extended pre-quit varenicline treatment on smoking behavior and short-term abstinence: a randomized clinical trial. Clin Pharmacol Ther 2012;91:172–80. 10.1038/clpt.2011.31722130118
  97. Stapleton J. Cigarette smoking prevalence, cessation and relapse. Stat Methods Med Res 1998;7:187–203. 10.1177/0962280298007002069654641
  98. West R, Shiffman S. Fast Facts: Smoking Cessation. 3rd edn. Abingdon: Health Press Ltd; 2016.
  99. McEwen A, West R, McRobbie H. Motives for smoking and their correlates in clients attending Stop Smoking treatment services. Nicotine Tob Res 2008;10:843–50. 10.1080/1462220080202724818569758
  100. Leaviss J, Sullivan W, Ren S, Everson-Hock E, Stevenson M, Stevens JW, et al. What is the clinical effectiveness and cost-effectiveness of cytisine compared with varenicline for smoking cessation? A systematic review and economic evaluation. Health Technol Assess 2014;18(33). 10.3310/hta18330
← Discussion and conclusionsAcknowledgements →

Attribution. Paul Aveyard; Nicola Lindson; Sarah Tearne; Rachel Adams; Khaled Ahmed; Rhona Alekna et al. (2018). Nicotine preloading for smoking cessation: the Preloading RCT. NIHR Journals Library. Copyright © Queen’s Printer and Controller of HMSO 2018. This work was produced by Aveyard et al. under the terms of a commissioning contract issued by the Secretary of State for Health and Social Care. This issue may be freely reproduced for the purposes of private research and study and extracts (or indeed, the full report) may be included in professional journals provided that suitable acknowledgement is made and the reproduction is not associated with any form of advertising. Applications for commercial reproduction should be addressed to: NIHR Journals Library, National Institute for Health Research, Evaluation, Trials and Studies Coordinating Centre, Alpha House, University of Southampton Science Park, Southampton SO16 7NS, UK. Licensed under CC BY 4.0. NCBI Bookshelf NBK518632. CC BY 4.0. Original source ↗. Text reproduced from the Bookshelf XML without changing wording; figures, images and supplements are not reproduced.

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