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Outcomes of specialist physiotherapy for functional motor disorder: the Physio4FMD RCT · References

References

CC BY 4.0 · National Institute for Health and Care Research · approximately 7 min read

  1. Stone J, Carson A, Duncan R, Roberts R, Warlow C, Hibberd C, et al. Who is referred to neurology clinics?: the diagnoses made in 3781 new patients. Clin Neurol Neurosurg 2010;112:747–51. 10.1016/j.clineuro.2010.05.01120646830
  2. Gargalas S, Weeks R, Khan-Bourne N, Shotbolt P, Simblett S, Ashraf L, et al. Incidence and outcome of functional stroke mimics admitted to a hyperacute stroke unit. J Neurol Neurosurg Psychiatry 2015;88:2–6. 10.1136/jnnp-2015-31111426319438
  3. Hallett M, Aybek S, Dworetzky BA, McWhirter L, Staab JP, Stone J. Functional neurological disorder: new subtypes and shared mechanisms. Lancet Neurol 2022;21:537–50. 10.1016/s1474-4422(21)00422-135430029
  4. Tinazzi M, Morgante F, Marcuzzo E, Erro R, Barone P, Ceravolo R, et al. Clinical correlates of functional motor disorders: an Italian multicenter study. Mov Disord Clin Pract 2020;7:920–9. 10.1002/mdc3.1307733163563
  5. Butler M, Shipston-Sharman O, Seynaeve M, Bao J, Pick S, Bradley-Westguard A, et al. International online survey of 1048 individuals with functional neurological disorder. Eur J Neurol 2021;28:3591–602. 10.1111/ene.1501834245646
  6. Gelauff J, Stone J, Edwards MJ, Carson A. The prognosis of functional (psychogenic) motor symptoms: a systematic review. J Neurol Neurosurg Psychiatry 2014;85:220–6. 10.1136/jnnp-2013-30532124029543
  7. Gelauff JM, Carson A, Ludwig L, Tijssen MAJ, Stone J. The prognosis of functional limb weakness: a 14-year case-control study. Brain 2019;142:2137–48. 10.1093/brain/awz13831167232
  8. Carson A, Stone J, Hibberd C, Murray G, Duncan R, Coleman R, et al. Disability, distress and unemployment in neurology outpatients with symptoms ‘unexplained by organic disease’. J Neurol Neurosurg Psychiatry 2011; 82:810–3. 10.1136/jnnp.2010.220640.21257981
  9. O’Mahony B, Nielsen G, Baxendale S, Edwards MJ, Yogarajah M. Economic cost of functional neurologic disorders: a systematic review. Neurology 2023;101:e202–14. 10.1212/wnl.000000000020738837339887
  10. Perez DL, Edwards MJ, Nielsen G, Kozlowska K, Hallett M, Curt Lafrance W. Decade of progress in motor functional neurological disorder: continuing the momentum. J Neurol Neurosurg Psychiatry 2021;92:668–77. 10.1136/jnnp-2020-323953
  11. Edwards MJ, Adams RA, Brown H, Parees I, Friston KJ. A Bayesian account of ‘hysteria’. Brain 2012;135:3495–512. 10.1093/brain/aws12922641838
  12. Jungilligens J, Paredes-Echeverri S, Popkirov S, Barrett LF, Perez DL. A new science of emotion: implications for functional neurological disorder. Brain 2022;145:2648–63. 10.1093/brain/awac20435653495
  13. Reynolds JR. Remarks on paralysis and other disorders of motion and sensation dependent on idea. BMJ 1869;2:483–5.
  14. Trieschmann RB, Stolov WC, Montgomery ED. An approach to the treatment of abnormal ambulation resulting from conversion reaction. Arch Phys Med Rehabil 1970;51:198–206.5442748
  15. Nielsen G, Stone J, Edwards MJ. Physiotherapy for functional (psychogenic) motor symptoms: a systematic review. J Psychosom Res 2013;75:93–102. 10.1016/j.jpsychores.2013.05.00623915764
  16. Jordbru AA, Smedstad LM, Klungsøyr O, Martinsen EW. Psychogenic gait disorder: a randomized controlled trial of physical rehabilitation with one-year follow-up. J Rehabil Med 2014;46:181–7.24248149
  17. Czarnecki K, Thompson JM, Seime R, Geda YE, Duffy JR, Ahlskog JE. Functional movement disorders: successful treatment with a physical therapy rehabilitation protocol. Parkinsonism Relat Disord 2012;18:247–51. 10.1016/j.parkreldis.2011.10.01122113131
  18. Nielsen G, Stone J, Matthews A, Brown M, Sparkes C, Farmer R, et al. Physiotherapy for functional motor disorders: a consensus recommendation. J Neurol Neurosurg Psychiatry 2015;86:1113–9. 10.1136/jnnp-2014-30925525433033
  19. Nielsen G, Ricciardi L, Demartini B, Hunter R, Joyce E, Edwards MJ. Outcomes of a 5-day physiotherapy programme for functional (psychogenic) motor disorders. J Neurol 2015;262:674–81. 10.1007/s00415-014-7631-125557282
  20. Nielsen G, Buszewicz M, Stevenson F, Hunter R, Holt K, Dudziec M, et al. Randomised feasibility study of physiotherapy for patients with functional motor symptoms. J Neurol Neurosurg Psychiatry 2017;88:484–90. 10.1136/jnnp-2016-31440827694498
  21. Schulz KF, Altman DG, Moher D. CONSORT 2010 statement: updated guidelines for reporting parallel group randomised trials. BMC Med 2010;8:18. 10.1186/1741-7015-8-1820334633
  22. Husereau D, Drummond M, Augustovski F, de Bekker-Grob E, Briggs AH, Carswell C, et al. Consolidated Health Economic Evaluation Reporting Standards 2022 (CHEERS 2022) statement: updated reporting guidance for health economic evaluations. MDM Policy Pract 2022;3:100063–11. 10.1177/23814683211061097
  23. Nielsen G, Stone J, Buszewicz M, Carson A, Goldstein LH, Holt K, et al.; Physio4FMD Collaborative Group. Physio4FMD: protocol for a multicentre randomised controlled trial of specialist physiotherapy for functional motor disorder. BMC Neurol 2019;19:242. 10.1186/s12883-019-1461-931638942
  24. Marston L, Le M, Ricciardi F, Nazareth I, Carson A, Edwards M, et al. COVID-19 and the Physio4FMD trial: impact, mitigating strategies and analysis plans. Contemp Clin Trials Commun 2023;33:101124. 10.1016/j.conctc.2023.10112437008795
  25. Nielsen G, Holt K. Physio4FMD Programme Workbook 2.0. London: St George’s, University of London Online Resource; 2023. 10.24376/rd.sgul.23967024.v1
  26. Nielsen G, Holt K. Physio4FMD Intervention Manual. London: St George’s, University of London; 2023.
  27. Nielsen G, Stone J, Lee TC, Goldstein LH, Marston L, Hunter RM, et al. Specialist physiotherapy for functional motor disorder in England and Scotland (Physio4FMD): a pragmatic, multicentre, phase 3 randomised controlled trial. Lancet Neurol 2024;23:675–86. 10.1016/s1474-4422(24)00135-238768621
  28. Hunter RM, Nielsen G, Le Novere M, Marston L, Lee TC, Stone J, et al. Cost-utility of specialist physiotherapy for functional motor disorder (Physio4FMD): economic analysis of a pragmatic randomised control trial. Neurol Clin Pract 2025;15:e200465. httpd://doi.org/10.1212/CPJ.0000000000200465.40190588
  29. Nielsen G, Lee TC, Marston L, Carson A, Edwards MJ, Goldstein LH, et al. Which factors predict outcome from specialist physiotherapy for functional motor disorder? Prognostic modelling of the Physio4FMD intervention. Journal of Psychosomatic Research 2025; 190:112056. doi: 10.1016/j.jpsychores.2025.112056.39952010
  30. Science Animated with the Physio4FMD Collaborative Group. Animation Plain English Summary of the Physio4FMD RCT: A Randomised Trial of Specialist Physiotherapy for Functional Motor Disorder. 2024. URL: https://youtu.be/pRgVoL9nFgo?feature=shared (accessed 10 November 2024).
  31. Pick S, Anderson DG, Asadi-Pooya AA, Aybek S, Baslet G, Bloem BR, et al. Outcome measurement in functional neurological disorder: a systematic review and recommendations. J Neurol Neurosurg Psychiatry 2020;91:638–49. 10.1136/jnnp-2019-32218032111637
  32. Gallagher M, Hares T, Spencer J, Bradshaw C, Webb I. The nominal group technique: a research tool for general practice? Fam Pract 1993;10:76–81.8477899
  33. Nicholson TR, Carson A, Edwards MJ, Goldstein LH, Hallett M, Mildon B, et al. Outcome measures for functional neurological disorder: a review of the theoretical complexities. J Neuropsychiatry Clin Neurosci 2020;32:33–42. 10.1176/appi.neuropsych.1906012831865871
  34. Demartini B, Batla A, Petrochilos P, Fisher L, Edwards MJ, Joyce E. Multidisciplinary treatment for functional neurological symptoms: a prospective study. J Neurol 2014;261:2370–7. 10.1007/s00415-014-7495-425239392
  35. McCormack R, Moriarty J, Mellers JD, Shotbolt P, Pastena R, Landes N, et al. Specialist inpatient treatment for severe motor conversion disorder: a retrospective comparative study. J Neurol Neurosurg Psychiatry 2013;85:895–900.24124043
  36. Gutkin M, McLean L, Brown R, Kanaan RA. Systematic review of psychotherapy for adults with functional neurological disorder. J Neurol Neurosurg Psychiatry 2020;92:36–44. 10.1136/jnnp-2019-321926
  37. Nielsen G. Twitter Dissemination of Animation of Plain Language Summary of the Physio4FMD RCT. X (Formally Twitter). 2024. URL: https://x.com/Sci_Ani/status/1816080898032615805 (accessed 18 November 2024).
  38. Nielsen G, Buszewicz M, Edwards, Stevenson MJ A qualitative study of the experiences and perceptions of patients with functional motor disorder Disabil Rehabil 2019; 42(14):2043–2048. doi: 10.1080/09638288.2018.1550685. Manuscipt in preparation.30669889
  39. Nettleton S, Watt I, O’Malley L, Duffey P. Understanding the narratives of people who live with medically unexplained illness. Patient Educ Couns 2005; 56:205–10. 10.1016/j.pec.2004.02.010.15653250
  40. Carson A, Lehn A. Epidemiology. In: Hallett M, Stone J, Carson A, editors. Functional Neurologic Disorders, Vol 139 of the Handbook of Clinical Neurology Series. Amsterdam: Elsevier; 2016. pp. 47–60.
  41. Mcloughlin C, Hoeritzauer I, Cabreira V, Aybek S, Adams C, Alty J, et al. Functional neurological disorder is a feminist issue. J Neurol Neurosurg Psychiatry 2023;1:7. 10.1136/jnnp-2022-330192
  42. Office for National Statistics (ONS). Ethnic Group, England and Wales: Census 2021. ONS Website, Statistical Bulletin. n.d. URL: www.ons.gov.uk/peoplepopulationandcommunity/culturalidentity/ethnicity/bulletins/ethnicgroupenglandandwales/census2021 (accessed 31 August 2023).
  43. Ethnicity | Scotland’s Census. n.d. URL: www.scotlandscensus.gov.uk/census-results/at-a-glance/ethnicity/ (accessed 13 October 2023).
  44. Edwards MJ, Yogarajah M, Stone J. Why functional neurological disorder is not feigning or malingering. Nat Rev Neurol 2023;19:246–56. 10.1038/s41582-022-00765-z36797425
  45. Ng BY. Hysteria: a cross-cultural comparison of its origins and history. Hist Psychiatry 1999;10:287–301. 10.1177/0957154X990100390111624005
  46. Brown RJ, Lewis-Fernández R. Culture and conversion disorder: implications for DSM-5. Psychiatry 2011;74:187–206. 10.1521/psyc.2011.74.3.18721916627
  47. Wilkins SS, Bourke P, Salam A, Akhtar N, D’Souza A, Kamran S, et al. Functional stroke mimics: Incidence and characteristics at a primary stroke center in the middle east. Psychosom Med 2018;80:416–21. 10.1097/PSY.000000000000056329394187
  48. Waheed W, Hughes-Morley A, Woodham A, Allen G, Bower P. Overcoming barriers to recruiting ethnic minorities to mental health research: a typology of recruitment strategies. BMC Psychiatry 2015;15:1–11. 10.1186/s12888-015-0484-z25609320
  49. FND Hope UK. Freedom of Information Project Aimed to Explore Issues Reported by NHS Clinicians and the FND Community Regarding Accesses to Treatment for People with FND. 2019. URL: www.fndhope.org.uk/freedom-of-information-project-aimed-to-explore-issues-reported-by-nhs-clinicians-and-the-fnd-community-regarding-accesses-to-treatment-for-people-with-fnd/ (accessed 6 December 2023).
  50. National Institute for Health and Care Excellence (NICE). Project Information | Rehabilitation for Chronic Neurological Disorders Including Acquired Brain Injury | Guidance [GID-NG10181]. NICE; n.d. URL: www.nice.org.uk/guidance/indevelopment/gid-ng10181 (accessed 29 November 2023).
  51. Weir S, Samnaliev M, Kuo TC, Tierney TS, Walleser Autiero S, Taylor RS, Schrag A. Short- and long-term cost and utilization of health care resources in Parkinson’s disease in the UK. Mov Disord 2018;33:974–81. 10.1002/mds.2730229603405
  52. Thompson A, Kobelt G, Berg J, Capsa D, Eriksson J, Miller D; European Multiple Sclerosis Platform. New insights into the burden and costs of multiple sclerosis in Europe: results for the United Kingdom. Mult Scler 2017;23:204–16. 10.1177/135245851770868728643587
  53. Nielsen G, Ricciardi L, Meppelink A, Holt K, Teodoro T, Edwards MJ. A simplified version of the Psychogenic Movement Disorders Rating Scale: the Simplified Functional Movement Disorders Rating Scale (S-FMDRS). Mov Disord Clin Pract 2017;4:710–6. 10.1002/mdc3.1247530363505
  54. National Neurosciences Advisory Group (NNAG). Optimum Clinical Pathway for Adults: Functional Neurological Disorder National Neurosciences Advisory Group (NNAG). Hertfordshire: NNAG; 2023.
  55. Nicholson T, Carson A, Edwards MJ, Goldstein L, Hallett M, Mildon B, et al. Outcome measures for functional neurological (conversion) disorder: a review of the theoretical complexities. J Neurol Clin Neurosci 2020;32:33–42.
  56. Yong K, Chin RFM, Shetty J, Hogg K, Burgess K, Lindsay M, et al.; the Edinburgh Paediatric FND Study Group. Functional neurological disorder in children and young people: incidence, clinical features, and prognosis. Dev Med Child Neurol 2023;65:1238–46. 10.1111/dmcn.1553836752054
← Additional information

Attribution. Glenn Nielsen; Louise Marston; Rachael Maree Hunter; Alan Carson; Laura H Goldstein; Kate Holt et al. (2025). Outcomes of specialist physiotherapy for functional motor disorder: the Physio4FMD RCT. National Institute for Health and Care Research. Copyright © 2025 Nielsen et al. Licensed under CC BY 4.0. NCBI Bookshelf NBK616747. CC BY 4.0. Original source ↗. Text reproduced from the Bookshelf XML without changing wording; figures, images and supplements are not reproduced.

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