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Library›Open textbooks›Decompressive craniectomy versus craniotomy for patients undergoing surgical evacuation of an acute subdural hematoma: RESCUE-ASDH RCT and cost effectiveness›Additional information

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Decompressive craniectomy versus craniotomy for patients undergoing surgical evacuation of an acute subdural hematoma: RESCUE-ASDH RCT and cost effectiveness · Additional information

Additional information

CC BY 4.0 · National Institute for Health and Care Research · approximately 6 min read

CRediT contribution statement

Peter Hutchinson (https://orcid.org/0000-0002-2796-1835): Conceptualisation, Formal analysis, Investigation, Methodology, Project administration, Supervision, Validation, Visualisation, Writing – reviewing and editing.

Harry Mee (https://orcid.org/0000-0002-1314-3962): Data curation, Formal analysis, Project administration, Visualisation, Writing – original draft, Writing – reviewing and editing.

Hadie Adams (https://orcid.org/0000-0001-8160-9026): Conceptualisation, Data curation, Investigation, Project administration, Visualisation.

Midhun Mohan (https://orcid.org/0000-0002-1865-8623): Writing – reviewing and editing.

Bhagavatula I Devi (https://orcid.org/0000-0003-3272-2465): Investigation, Supervision.

Christopher Uff (https://orcid.org/0000-0001-9787-8001): Investigation, Supervision.

Shumaila Hasan (https://orcid.org/0000-0002-0158-703X): Investigation, Supervision.

Mark Wilson (https://orcid.org/0000-0002-2346-4911): Investigation, Supervision.

Deepak Gupta (https://orcid.org/0000-0001-7698-5668): Investigation, Supervision.

Diederik Bulters (https://orcid.org/0000-0001-9884-9050): Investigation, Supervision.

Ardalan H Zolnourian (https://orcid.org/0000-0002-0428-179X): Investigation, Supervision.

Catherine McMahon (https://orcid.org/0000-0003-4484-7249): Investigation, Supervision.

Matthew Stovell (https://orcid.org/0000-0002-4172-4617): Investigation, Supervision.

Yahia Al-Tamimi (https://orcid.org/0000-0002-9014-2728): Investigation, Supervision.

Manoj Tewari (https://orcid.org/0000-0002-8963-5998): Investigation, Supervision.

Manjul Tripathi (https://orcid.org/0000-0002-5679-3439): Investigation, Supervision.

Simon Thomson (https://orcid.org/0000-0003-4827-1961): Investigation, Supervision.

Edoardo Viaroli (https://orcid.org/0000-0002-7318-4846): Investigation, Supervision.

Karen Caldwell (https://orcid.org/0000-0001-5604-8773): Data curation, Project administration, Resources.

Antonio Belli (https://orcid.org/0000-0002-3211-9933): Conceptualisation, Investigation, Supervision.

Andrew King (https://orcid.org/0000-0002-6546-7248): Conceptualisation.

Adel Helmy (https://orcid.org/0000-0002-0531-0556): Investigation, Supervision.

Ivan Timofeev (https://orcid.org/0000-0002-1168-0393): Investigation, Supervision.

Sarah Pyne (https://orcid.org/0000-0003-0093-9125): Data curation, Formal analysis, Visualisation, Writing – original draft, Writing – reviewing and editing.

Dhaval Shukla (https://orcid.org/0000-0001-7613-1929): Investigation, Supervision.

Dhananjaya I Bhat (https://orcid.org/0000-0001-8595-8311): Investigation, Supervision.

Andrew Maas (https://orcid.org/0000-0003-1612-1264): Conceptualisation, Supervision.

Franco Servadei (https://orcid.org/0000-0002-3595-3464): Conceptualisation, Investigation, Supervision.

Geoffrey Manley: Conceptualisation, Supervision.

Garry Barton (https://orcid.org/0000-0001-9040-011X): Conceptualisation, Data curation, Formal analysis, Methodology, Visualisation, Writing – original draft, Writing – reviewing and editing.

David Turner (https://orcid.org/0000-0002-1689-4147): Conceptualisation, Data curation, Formal analysis, Methodology, Visualisation, Writing – original draft, Writing – reviewing and editing.

Natalia Igosheva (https://orcid.org/0000-0002-1530-7879): Resources.

Alicia Gore (https://orcid.org/0000-0002-1991-6719): Resources.

Tapiwa Tungamirai: Data curation, Project administration, Resources, Software.

Kerstin Wolf (https://orcid.org/0000-0001-8274-6532): Resources, Data curation, Project administration, Software.

Carol Davis-Wilkie (https://orcid.org/0000-0001-7315-4025): Data curation, Project administration, Resources, Software, Writing – reviewing and editing.

Kamila Walker: Resources, Data curation, Software.

Michelle Jillings (https://orcid.org/0000-0003-0438-2256): Resources.

Christopher Bushell (https://orcid.org/0000-0003-2723-597X): Resources, Data curation, Software.

Carole Turner (https://orcid.org/0000-0002-8297-4890): Conceptualisation, Project administration, Writing – reviewing and editing.

David Menon (https://orcid.org/0000-0002-3228-9692): Conceptualisation, Supervision.

Barbara Gregson (https://orcid.org/0000-0003-4868-9137): Data curation, Formal analysis, Methodology, Writing – original draft, Writing – reviewing and editing.

Angelos Kolias (https://orcid.org/0000-0003-3992-0587): Conceptualisation, Data curation, Formal analysis, Investigation, Methodology, Project administration, Supervision, Validation, Visualisation, Writing – reviewing and editing.

Patient data statement

This work uses data provided by patients and collected by the NHS as part of their care and support. Using patient data is vital to improve health and care for everyone. There is huge potential to make better use of information from people’s patient records, to understand more about disease, develop new treatments, monitor safety, and plan NHS services. Patient data should be kept safe and secure, to protect everyone’s privacy, and it’s important that there are safeguards to make sure that it is stored and used responsibly. Everyone should be able to find out about how patient data are used. #datasaveslives You can find out more about the background to this citation here: https://understandingpatientdata.org.uk/data-citation

Data-sharing statement

The data are managed and shared in a way that safeguards the confidentiality and anonymity of participants and is consistent with the terms of consent signed by participants. All data requests should be submitted to the corresponding author for consideration. Access to anonymised data may be granted following review.

Ethics statement

This research has been conducted in accordance with the World Medical Association Declaration of Helsinki. Ethics approval was granted from NRES committee North West – Haydock for the trial on 17 July 2014, REC references were UK Ref 14 NW 1076, and Scotland REC Ref 15 SS 0193.

Information governance statement

Cambridge University is committed to handling all personal information in line with the UK Data Protection Act (2018) and the General Data Protection Regulation (EU GDPR) 2016/679. Under the Data Protection legislation, Cambridge University is the Data Controller, and you can find out more about how we handle personal data, including how to exercise your individual rights, and the contact details for our Data Protection Officer here: www.information-compliance.admin.cam.ac.uk/contact-us.

Disclosure of interests

Full disclosure of interests: Completed ICMJE forms for all authors, including all related interests, are available in the toolkit on the NIHR Journals Library report publication page at https://doi.org/10.3310/GJPH0512.

Primary conflicts of interest: Peter Hutchinson was a member of the HTA IP Panel (1 January 2016–31 May 2018) and HTA Prioritisation Committee B (in hospital) (1 January 2016–31 March 2022).

Garry Barton was a member of the HTA General Committee (1 March 2023–30 November 2026).

CTUs funded by NIHR (end date 31 August 2021).

Copyright and credit statement

Every effort has been made to obtain the necessary permissions for reproduction, to credit original sources appropriately and to respect copyright requirements. However, despite our diligence, we acknowledge the possibility of unintentional omissions or errors, and we welcome notifications of any concerns regarding copyright or permissions.

Publications

Hutchinson PJ, Kolias AG, Timofeev IS, Corteen EA, Czosnyka M, Timothy J, et al. RESCUEicp Trial Collaborators. Trial of decompressive craniectomy for traumatic intracranial hypertension. N Engl J Med 2016;375:1119–30. https://doi.org/10.1056/NEJMoa1605215

Fountain DM, Kolias AG, Lecky FE, Bouamra O, Lawrence T, Adams H, et al. Survival trends after surgery for acute subdural hematoma in adults over a 20-year period. Ann Surg 2017;265:590–6.

Chari A, Jamjoom AA, Edlmann E, Ahmed AI, Coulter IC, Ma R, et al. British Neurosurgical Trainee Research Collaborative: five years on. Acta Neurochir 2018;160:23–8. https://doi.org/10.1007/s00701-017-3351-5

Kolias AG, Viaroli E, Rubiano AM, Adams H, Khan T, Gupta D, et al. The current status of decompressive craniectomy in traumatic brain injury. Curr Trauma Rep 2018;4:326–32. https://doi.org/10.1007/s40719-018-0147-x

Kolias AG, Rubiano AM, Figaji A, Servadei F, Hutchinson PJ. Traumatic brain injury: global collaboration for a global challenge. Lancet Neurol 2019;18:136–7. https://doi.org/10.1016/S1474-4422(18)30494-0

Clark D, Joannides A, Ibrahim Abdallah O, Olufemi Adeleye A, Hafid Bajamal A, Bashford T, et al. Management and outcomes following emergency surgery for traumatic brain injury – a multicentre, international, prospective cohort study (the Global Neurotrauma Outcomes Study). Int J Surg Protoc 2020;20:1–7. https://doi.org/10.1016/j.isjp.2020.02.001

Smith M, Servadei F, Hutchinson PJ. What is new in decompressive craniectomy in neurological emergencies: the good, the bad and the ugly. Intensive Care Med 2020;46:1023–6. https://doi.org/10.1007/s00134-020-05933-7

Birchall M, Blazeby J, Blencowe N, Donovan J, Elliott D, Jepson M, et al. Understanding risks, mitigation and innovation for surgery in a COVID-19 world. Br J Surg 2020;107:e247. https://doi.org/10.1002/bjs.11691

Iaccarino C, Kolias A, Adelson PD, Rubiano AM, Viaroli E, Buki A, et al. Consensus statement from the international consensus meeting on post-traumatic cranioplasty. Acta Neurochir 2021;163:423–40. https://doi.org/10.1007/s00701-020-04663-5

Mohan M, Layard Horsfall H, Solla DJF, Robertson FC, Adeleye AO, Teklemariam TL, et al. Decompressive craniotomy: an international survey of practice. Acta Neurochir 2021;163:1415–22. https://doi.org/10.1007/s00701-021-04783-6

Mishra T, Kishore K, Jayan M, Thaploo D, Shanbhag NC, Bhat DI, et al. When the bone flap expands like bellows of accordion: feasibility study using novel technique of expansile (hinge) craniotomy for severe traumatic brain injury. Neurol India. 2021;69:973–8. https://doi.org/10.4103/0028-3886.325310

Clark D, Joannides A, Adeleye AO, Bajamal AH, Bashford T, Biluts H, et al. Global Neurotrauma Outcomes Study Collaborative. Casemix, management, and mortality of patients receiving emergency neurosurgery for traumatic brain injury in the Global Neurotrauma Outcomes Study: a prospective observational cohort study. Lancet Neurol 2022;21:438–49. https://doi.org/10.1016/S1474-4422(22)00037-0

Hutchinson PJ, Adams H, Mohan M, Devi BI, Uff C, Hasan S, et al. Decompressive Craniectomy versus Craniotomy for Acute Subdural Hematoma. New Engl J Med 2023;388:2219–29. https://doi.org/10.1056/nejmoa2214172

Pyne SC, Barton GR, Turner DA, Mee H, Gregson B, Kolias AG, et al. on behalf of the RESCUE-ASDH Trial Collaborators. Cost-effectiveness of craniotomy versus decompressive craniectomy, for UK patients with traumatic acute subdural hematoma. BMJ Open 2024;14:e085084. https://doi.org/10.1136/bmjopen-2024-085084

Disclaimers

This article presents independent research funded by the National Institute for Health and Care Research (NIHR). The views and opinions expressed by authors in this publication are those of the authors and do not necessarily reflect those of the NHS, the NIHR, the HTA programme or the Department of Health and Social Care. If there are verbatim quotations included in this publication the views and opinions expressed by the interviewees are those of the interviewees and do not necessarily reflect those of the authors, those of the NHS, the NIHR, the HTA programme or the Department of Health and Social Care.

← ReferencesList of supplementary material →

Attribution. Peter Hutchinson; Harry Mee; Hadie Adams; Midhun Mohan; Bhagavatula I Devi; Christopher Uff et al. (2026). Decompressive craniectomy versus craniotomy for patients undergoing surgical evacuation of an acute subdural hematoma: RESCUE-ASDH RCT and cost effectiveness. National Institute for Health and Care Research. Copyright © 2026 Hutchinson et al. Licensed under CC BY 4.0. NCBI Bookshelf NBK624437. CC BY 4.0. Original source ↗. Text reproduced from the Bookshelf XML without changing wording; figures, images and supplements are not reproduced.

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