In respect of estimations for a future trial, based on the findings presented here, namely the proportions with sustained CO-validated abstinence in each arm (6.25% in the intervention, 0% in UC) and assuming 0.05 alpha, 90% power and an ICC of 0.01, a future cRCT would require 12 participants per cluster (the feasibility average) and 16 sites per arm, totalling 192 participants per arm and 384 participants across both conditions. This sample size estimate assumes equal cluster sizes. These estimates are not adjusted for attrition, as it is anticipated that the primary analysis will be by ITT and participants lost to follow-up will be assumed to have relapsed entailing no loss of power.
Exploring the uptake and use of electronic cigarettes provided to smokers accessing homeless centres: a four-centre cluster feasibility trial · Outcomes and estimations
Outcomes and estimations
Attribution. Sharon Cox; Allison Ford; Jinshuo Li; Catherine Best; Allan Tyler; Deborah J Robson et al. (2021). Exploring the uptake and use of electronic cigarettes provided to smokers accessing homeless centres: a four-centre cluster feasibility trial. NIHR Journals Library. Copyright © Queen’s Printer and Controller of HMSO 2021. This work was produced by Cox et al. under the terms of a commissioning contract issued by the Secretary of State for Health and Social Care. This issue may be freely reproduced for the purposes of private research and study and extracts (or indeed, the full report) may be included in professional journals provided that suitable acknowledgement is made and the reproduction is not associated with any form of advertising. Applications for commercial reproduction should be addressed to: NIHR Journals Library, National Institute for Health Research, Evaluation, Trials and Studies Coordinating Centre, Alpha House, University of Southampton Science Park, Southampton SO16 7NS, UK. Licensed under CC BY 4.0. NCBI Bookshelf NBK570404. CC BY 4.0. Original source ↗. Text reproduced from the Bookshelf XML without changing wording; figures, images and supplements are not reproduced.