The CARE pilot RCT gave inconclusive results about the effects of medical management and intervention (using neurosurgical resection or stereotactic radiosurgery) compared with medical management alone for brain cavernoma.40 However, the recruitment rate did confirm that there is uncertainty about the use of both types of intervention in the UK, and that stereotactic radiosurgery was twice as likely as neurosurgical resection to be selected as the type of intervention to use in a RCT, confirming ongoing equipoise in the clinical community about the use of stereotactic radiosurgery for symptomatic brain cavernoma, despite the existence of a clinical commissioning policy in NHS England.29
Medical management and intervention (using neurosurgical resection or stereotactic radiosurgery) versus medical management alone for symptomatic brain cavernoma: the CARE pilot RCT · Implication for decision-makers
Implication for decision-makers
Attribution. Rustam Al-Shahi Salman; Neil Kitchen; Laura Forsyth; Vijeya Ganesan; Peter S Hall; Kirsty Harkness et al. (2025). Medical management and intervention (using neurosurgical resection or stereotactic radiosurgery) versus medical management alone for symptomatic brain cavernoma: the CARE pilot RCT. National Institute for Health and Care Research. Copyright © 2025 Al-Shahi Salman et al. Licensed under CC BY 4.0. NCBI Bookshelf NBK617151. CC BY 4.0. Original source ↗. Text reproduced from the Bookshelf XML without changing wording; figures, images and supplements are not reproduced.