Pediatric Brain Cancer (CPTAC/CHOP, Cell 2020)

Summary

Pediatric Brain Cancer (CPTAC/CHOP, Cell 2020) is a study catalogued by cBioPortal DataHub under the cancer-type code brain. EvidenceHelix groups it with brain and nervous system studies.

Study description

Integrated proteogenomic characterization across major histological types of pediatric brain cancer . We report a comprehensive proteogenomics analysis, including whole-genome sequencing, RNA sequencing, and proteomics and phosphoproteomics profiling, of 218 tumors across 7 histological types of childhood brain cancer: low-grade glioma (n = 93), ependymoma (32), high-grade glioma (25), medulloblastoma (22), ganglio-glioma (18), craniopharyngioma (16), and atypical teratoid rhabdoid tumor (12). Proteomics data identify common biological themes that span histological boundaries, suggesting that treatments used for one histological type may be applied effectively to other tumors sharing similar proteomics features. Immune landscape characterization reveals diverse tumor microenvironments across and within diagnoses. Proteomics data further reveal functional effects of somatic mutations and copy number variations (CNVs) not evident in transcriptomics data.

Text as published in the source's study metadata.

Citation & PubMed

CPTAC, Cell 2020

Linked PubMed records: PMID 33242424

Source & licence

Metadata from cBioPortal DataHub at e1b75cd25b, available under the ODC Open Database License (ODbL) 1.0. See the Source metadata tab for every field.

Source metadata

Study identifier

brain_cptac_2020

Short name

Pediatric Brain Cancer (CPTAC/CHOP, Cell 2020)

Source cancer-type code

brain

Reference genome

hg19

Source access groups

PUBLIC

Original study

View on cBioPortal

Metadata file

meta_study.txt at e1b75cd25b

Database licence

ODC Open Database License (ODbL) 1.0

Study-level metadata only (title, description, cancer-type code, citation, PubMed ids). No patient, sample, mutation or clinical data, and no publication full text, is included. Individual studies may carry their own terms; follow each study's source links before reusing its data.

Citations

CPTAC, Cell 2020

• PubMed record 33242424 ↗

Citation counts are not part of the source metadata and are not shown.

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